Search Results - "Schell, Michael J."

A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study by Scott, Jacob G, MD, Berglund, Anders, PhD, Schell, Michael J, Prof, Mihaylov, Ivaylo, PhD, Fulp, William J, MS, Yue, Binglin, MS, Welsh, Eric, PhD, Caudell, Jimmy J, MD, Ahmed, Kamran, MD, Strom, Tobin S, MD, Mellon, Eric, MD, Venkat, Puja, MD, Johnstone, Peter, Prof, Foekens, John, Prof, Lee, Jae, Prof, Moros, Eduardo, Prof, Dalton, William S, Prof, Eschrich, Steven A, PhD, McLeod, Howard, Prof, Harrison, Louis B, Prof, Torres-Roca, Javier F, Dr

“…Summary Background Despite its common use in cancer treatment, radiotherapy has not yet entered the era of precision medicine, and there have been no…”
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The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy by Knepper, Todd C, Montesion, Meagan, Russell, Jeffery S, Sokol, Ethan S, Frampton, Garrett M, Miller, Vincent A, Albacker, Lee A, McLeod, Howard L, Eroglu, Zeynep, Khushalani, Nikhil I, Sondak, Vernon K, Messina, Jane L, Schell, Michael J, DeCaprio, James A, Tsai, Kenneth Y, Brohl, Andrew S

“…Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy, which has demonstrated sensitivity to immune checkpoint inhibitor therapy. Here, we…”
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A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC by Schell, Michael J., Yang, Mingli, Teer, Jamie K., Lo, Fang Yin, Madan, Anup, Coppola, Domenico, Monteiro, Alvaro N. A., Nebozhyn, Michael V., Yue, Binglin, Loboda, Andrey, Bien-Willner, Gabriel A., Greenawalt, Danielle M., Yeatman, Timothy J.

“…Colorectal cancer (CRC) is a highly heterogeneous disease, for which prognosis has been relegated to clinicopathologic staging for decades. There is a need to…”
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Techniques to produce and evaluate realistic multivariate synthetic data by Heine, John, Fowler, Erin E. E., Berglund, Anders, Schell, Michael J., Eschrich, Steven

“…Data modeling requires a sufficient sample size for reproducibility. A small sample size can inhibit model evaluation. A synthetic data generation technique…”
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Randomized International Phase III Trial of ERCC1 and RRM1 Expression–Based Chemotherapy Versus Gemcitabine/Carboplatin in Advanced Non–Small-Cell Lung Cancer by BEPLER, Gerold, WILLIAMS, Charles, CHIAPPORI, Alberto, TANVETYANON, Tawee, PINDER-SCHENCK, Mary, GRAY, Jhanelle, HAURA, Eric, ANTONIA, Scott, FISCHER, Juergen R, SCHELL, Michael J, WEI CHEN, ZHONG ZHENG, SIMON, George, GADGEEL, Shirish, XIUHUA ZHAO, SCHREIBER, Fred, BRAHMER, Julie

“…We assessed whether chemotherapy selection based on in situ ERCC1 and RRM1 protein levels would improve survival in patients with advanced non-small-cell lung…”
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Co-evolution of somatic variation in primary and metastatic colorectal cancer may expand biopsy indications in the molecular era by Kim, Richard, Schell, Michael J, Teer, Jamie K, Greenawalt, Danielle M, Yang, Mingli, Yeatman, Timothy J

“…Metastasis is thought to be a clonal event whereby a single cell initiates the development of a new tumor at a distant site. However the degree to which…”
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A phase II study of RO4929097 in metastatic colorectal cancer by Strosberg, Jonathan R, Yeatman, Timothy, Weber, Jill, Coppola, Domenico, Schell, Michael J, Han, Gang, Almhanna, Khaldoun, Kim, Richard, Valone, Tiffany, Jump, Helen, Sullivan, Dan

“…Abstract Background The Notch signalling pathway is activated in a variety of malignancies and has been implicated in colorectal cancer progression. One of the…”
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Outcomes of Adrenalectomy for Isolated Synchronous Versus Metachronous Adrenal Metastases in Non–Small-Cell Lung Cancer: A Systematic Review and Pooled Analysis by TANVETYANON, Tawee, ROBINSON, Larya, SCHELL, Michael J, STRONG, Vivian E, KAPOOR, Rachna, COIT, Daniel G, BEPLER, Gerold

“…Several small studies have reported that an adrenalectomy for isolated adrenal metastasis in non-small-cell lung cancer (NSCLC), along with a surgical…”
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Phase I/II Study of the Src Inhibitor Dasatinib in Combination With Erlotinib in Advanced Non–Small-Cell Lung Cancer by HAURA, Eric B, TANVETYANON, Tawee, LANXI SONG, RAWAL, Bhupendra, SCHELL, Michael J, BEPLER, Gerold, CHIAPPORI, Alberto, WILLIAMS, Charles, SIMON, George, ANTONIA, Scott, GRAY, Jhanelle, LITSCHAUER, Sharon, TETTEH, Leticia, NEUGER, Anthony

“…Src family kinase (SFK) proteins are frequently activated in cancer and can coordinate tumor cell growth, survival, invasion, and angiogenesis. Given the…”
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Neutrophil to lymphocyte ratio, not platelet to lymphocyte or lymphocyte to monocyte ratio, is predictive of patient survival after resection of early-stage pancreatic ductal adenocarcinoma by Pointer, Jr, David T, Roife, David, Powers, Benjamin D, Murimwa, Gilbert, Elessawy, Sameh, Thompson, Zachary J, Schell, Michael J, Hodul, Pamela J, Pimiento, Jose M, Fleming, Jason B, Malafa, Mokenge P

“…NLR, PLR, and LMR have been associated with pancreatic ductal adenocarcinoma (PDAC) survival. Prognostic value and optimal cutpoints were evaluated to identify…”
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Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells by McFate, Thomas, Mohyeldin, Ahmed, Lu, Huasheng, Thakar, Jay, Henriques, Jeremy, Halim, Nader D., Wu, Hong, Schell, Michael J., Tsang, Tsz Mon, Teahan, Orla, Zhou, Shaoyu, Califano, Joseph A., Jeoung, Nam Ho, Harris, Robert A., Verma, Ajay

“…High lactate generation and low glucose oxidation, despite normal oxygen conditions, are commonly seen in cancer cells and tumors. Historically known as the…”
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A Phase II Study of Ibrutinib in Advanced Neuroendocrine Neoplasms by Al-Toubah, Taymeyah, Schell, Michael J, Cives, Mauro, Zhou, Jun-Min, Soares, Heloisa P, Strosberg, Jonathan R

“…Ibrutinib is an orally administered inhibitor of Bruton's tyrosine kinase (Btk). Preclinical data suggest that mast cells are recruited within neuroendocrine…”
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An integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy by Yang, Mingli, Davis, Thomas B, Pflieger, Lance, Nebozhyn, Michael V, Loboda, Andrey, Wang, Heiman, Schell, Michael J, Thota, Ramya, Pledger, W Jack, Yeatman, Timothy J

“…Over half of colorectal cancers (CRCs) are hard-wired to RAS/RAF/MEK/ERK pathway oncogenic signaling. However, the promise of targeted therapeutic inhibitors,…”
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Testosterone and Dihydrotestosterone Tissue Levels in Recurrent Prostate Cancer by TITUS, Mark A, SCHELL, Michael J, LIH, Fred B, TOMER, Kenneth B, MOHLER, James L

“…Purpose: Prostate cancer eventually recurs during androgen deprivation therapy despite castrate levels of serum androgens. Expression of androgen receptor and…”
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SARS-CoV-2 Period Seroprevalence and Related Factors, Hillsborough County, Florida, USA, October 2020-March 2021 by Giuliano, Anna R, Pilon-Thomas, Shari, Schell, Michael J, Abrahamsen, Martha, Islam, Jessica Y, Isaacs-Soriano, Kimberly, Kennedy, Kayoko, Dukes, Christopher W, Whiting, Junmin, Rathwell, Julie, Hensel, Jonathan A, Mangual, Leslie N, Schonbrunn, Ernst, Bikowitz, Melissa, Grassie, Dylan, Yang, Yan

“…Estimating the actual extent of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is challenging because virus test positivity data…”
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Randomized Phase III Trial of Gemcitabine-Based Chemotherapy With In Situ RRM1 and ERCC1 Protein Levels for Response Prediction in Non–Small-Cell Lung Cancer by Reynolds, Craig, Obasaju, Coleman, Schell, Michael J, Li, Xueli, Zheng, Zhong, Boulware, David, Caton, John R, Demarco, Linda C, O'Rourke, Mark A, Shaw Wright, Gail, Boehm, Kristi A, Asmar, Lina, Bromund, Jane, Peng, Guangbin, Monberg, Matthew J, Bepler, Gerold

“…We evaluated the efficacy of gemcitabine versus gemcitabine and carboplatin in patients with advanced non-small-cell lung cancer (NSCLC) and a performance…”
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Myosin Vb mediates Cu+ export in polarized hepatocytes by Gupta, Arnab, Schell, Michael J, Bhattacharjee, Ashima, Lutsenko, Svetlana, Hubbard, Ann L

“…The cellular machinery responsible for Cu(+)-stimulated delivery of the Wilson-disease-associated protein ATP7B to the apical domain of hepatocytes is poorly…”
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Randomized, placebo-controlled trial evaluating the safety of one-year administration of green tea catechins by Kumar, Nagi B, Pow-Sang, Julio, Spiess, Philippe E, Park, Jong, Salup, Raoul, Williams, Christopher R, Parnes, Howard, Schell, Michael J

“…Although preclinical, epidemiological and prior clinical trial data suggest that green tea catechins (GTCs) may reduce prostate cancer (PCa) risk, several…”
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Do mammals make all their own inositol hexakisphosphate? by Letcher, Andrew J, Schell, Michael J, Irvine, Robin F

“…A highly specific and sensitive mass assay for inositol hexakisphosphate (InsP6) was characterized. This centres around phosphorylating InsP6 with [32P]ATP…”
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Back in the water: the return of the inositol phosphates by Irvine, Robin F, Schell, Michael J

“…Following the discovery of inositol-1,4,5-trisphosphate as a second messenger, many other inositol phosphates were discovered in quick succession, with some…”
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