Search Results - "Schejter, Eyal D."

Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia by Segal, Dagan, Dhanyasi, Nagaraju, Schejter, Eyal D., Shilo, Ben-Zion

“…Indirect flight muscles (IFMs) in Drosophila are generated during pupariation by fusion of hundreds of myoblasts with larval muscle templates (myotubes). Live…”
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A WntD-Dependent Integral Feedback Loop Attenuates Variability in Drosophila Toll Signaling by Rahimi, Neta, Averbukh, Inna, Haskel-Ittah, Michal, Degani, Neta, Schejter, Eyal D., Barkai, Naama, Shilo, Ben-Zion

“…Patterning by morphogen gradients relies on the capacity to generate reproducible distribution profiles. Morphogen spread depends on kinetic parameters,…”
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The Edges of Pancreatic Islet β Cells Constitute Adhesive and Signaling Microdomains by Geron, Erez, Boura-Halfon, Sigalit, Schejter, Eyal D., Shilo, Ben-Zion

“…Pancreatic islet β cells are organized in rosette-like structures around blood vessels and exhibit an artery-to-vein orientation, but they do not display the…”
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Directing exocrine secretory vesicles to the apical membrane by actin cables generated by the formin mDia1 by Geron, Erez, Schejter, Eyal D., Shilo, Ben-Zion

“…The final stage in exocrine secretion involves translocation of vesicles from their storage areas to the apical membrane. We show that actin-coated secretory…”
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Self-Organized Shuttling: Generating Sharp Dorsoventral Polarity in the Early Drosophila Embryo by Haskel-Ittah, Michal, Ben-Zvi, Danny, Branski-Arieli, Merav, Schejter, Eyal D., Shilo, Ben-Zion, Barkai, Naama

“…Morphogen gradients pattern tissues and organs during development. When morphogen production is spatially restricted, diffusion and degradation are sufficient…”
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The actin regulator N-WASp is required for muscle-cell fusion in mice by Gruenbaum-Cohen, Yael, Harel, Itamar, Umansky, Kfir-Baruch, Tzahor, Eldad, Snapper, Scott B., Shilo, Ben-Zion, Schejter, Eyal D.

“…A fundamental aspect of skeletal myogenesis involves extensive rounds of cell fusion, in which individual myoblasts are incorporated into growing muscle…”
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The Drosophila formin Fhos is a primary mediator of sarcomeric thin-filament array assembly by Shwartz, Arkadi, Dhanyasi, Nagaraju, Schejter, Eyal D, Shilo, Ben-Zion

“…Actin-based thin filament arrays constitute a fundamental core component of muscle sarcomeres. We have used formation of the indirect flight musculature for…”
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Sequential activation of ETS proteins provides a sustained transcriptional response to EGFR signaling by Shwartz, Arkadi, Yogev, Shaul, Schejter, Eyal D, Shilo, Ben-Zion

“…How signal transduction, which is dynamic and fluctuating by nature, is converted into a stable trancriptional response, is an unanswered question in…”
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Apical Secretion in Epithelial Tubes of the Drosophila Embryo Is Directed by the Formin-Family Protein Diaphanous by Massarwa, R'ada, Schejter, Eyal D., Shilo, Ben-Zion

“…Apical localization of filamentous actin (F-actin) is a common feature of epithelial tubes in multicellular organisms. However, its origins and function are…”
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WIP/WASp-Based Actin-Polymerization Machinery Is Essential for Myoblast Fusion in Drosophila by Massarwa, R'ada, Carmon, Shari, Shilo, Ben-Zion, Schejter, Eyal D.

“…Formation of syncytial muscle fibers involves repeated rounds of cell fusion between growing myotubes and neighboring myoblasts. We have established that Wsp,…”
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Apical targeting of the formin Diaphanous in Drosophila tubular epithelia by Rousso, Tal, Shewan, Annette M, Mostov, Keith E, Schejter, Eyal D, Shilo, Ben-Zion

“…Apical secretion from epithelial tubes of the Drosophila embryo is mediated by apical F-actin cables generated by the formin-family protein Diaphanous (Dia)…”
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The SCAR and WASp nucleation-promoting factors act sequentially to mediate Drosophila myoblast fusion by Gildor, Boaz, Massarwa, R'ada, Shilo, Ben-Zion, Schejter, Eyal D

“…The actin nucleation‐promoting factors SCAR/WAVE and WASp, together with associated elements, mediate the formation of muscle fibres through myoblast fusion…”
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N-wasp is required for structural integrity of the blood-testis barrier by Xiao, Xiang, Mruk, Dolores D, Tang, Elizabeth I, Massarwa, R'ada, Mok, Ka Wai, Li, Nan, Wong, Chris K C, Lee, Will M, Snapper, Scott B, Shilo, Ben-Zion, Schejter, Eyal D, Cheng, C Yan

“…During spermatogenesis, the blood-testis barrier (BTB) segregates the adluminal (apical) and basal compartments in the seminiferous epithelium, thereby…”
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Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery by Yogev, Shaul, Schejter, Eyal D, Shilo, Ben-Zion

“…The release of signaling molecules from neurons must be regulated, to accommodate their highly polarized structure. In the developing Drosophila visual system,…”
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Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways by Assa-Kunik, Efrat, Torres, Isabel L., Schejter, Eyal D., Johnston, Daniel St, Shilo, Ben-Zion

“…The specification of polar, main-body and stalk follicle cells in the germarium of the Drosophila ovary plays a key role in the formation of the egg chamber…”
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Orienting the Direction of EGFR Activation by Shilo, Ben-Zion, Schejter, Eyal D.

“…Morphogens are typically distributed symmetrically from their source of production. In this issue of Developmental Cell, Peng et al. (2012) demonstrate that a…”
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Myoblast fusion: Experimental systems and cellular mechanisms by Schejter, Eyal D.

“…Fusion of myoblasts gives rise to the large, multi-nucleated muscle fibers that power and support organism motion and form. The mechanisms underlying this…”
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The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release by Rotkopf, Shay, Hamberg, Yuval, Aigaki, Toshiro, Snapper, Scott B, Shilo, Ben-Zion, Schejter, Eyal D

“…WASp family proteins serve as conserved regulators of branched microfilament array formation via the Arp2/3 actin polymerization machinery. We have identified…”
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SCAR Is a Primary Regulator of Arp2/3-Dependent Morphological Events in Drosophila by Zallen, Jennifer A., Cohen, Yehudit, Hudson, Andrew M., Cooley, Lynn, Wieschaus, Eric, Schejter, Eyal D.

“…The Arp2/3 complex and its activators, Scar/WAVE and Wiskott-Aldrich Syndrome protein (WASp), promote actin polymerization in vitro and have been proposed to…”
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Structured RhoGEF recruitment drives myosin II organization on large exocytic vesicles by Kamalesh, Kumari, Segal, Dagan, Avinoam, Ori, Schejter, Eyal D, Shilo, Ben-Zion

“…The Rho family of GTPases plays a crucial role in cellular mechanics by regulating actomyosin contractility through the parallel induction of actin and myosin…”
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