Search Results - "Scheiter, Alexander"

Identification of CD133 + intercellsomes in intercellular communication to offset intracellular signal deficit by Kaneko, Kota, Liang, Yan, Liu, Qing, Zhang, Shuo, Scheiter, Alexander, Song, Dan, Feng, Gen-Sheng

“…CD133 (prominin 1) is widely viewed as a cancer stem cell marker in association with drug resistance and cancer recurrence. Herein, we report that with…”
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Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis by Klemm, Sophie, Evert, Katja, Utpatel, Kirsten, Muggli, Alexandra, Simile, Maria M, Chen, Xin, Evert, Matthias, Calvisi, Diego F, Scheiter, Alexander

“…Upregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral oncogene homolog…”
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Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade by Haimerl, Michael, Utpatel, Kirsten, Götz, Andrea, Zeman, Florian, Fellner, Claudia, Nickel, Dominik, Luerken, Lukas, Brennfleck, Frank, Stroszczynski, Christian, Scheiter, Alexander, Verloh, Niklas

“…This study aimed to assess the degree of differentiation of hepatocellular carcinoma (HCC) using Gd-EOB-DTPA-assisted magnetic resonance imaging (MRI) with T1…”
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RASSF1A independence and early galectin‐1 upregulation in PIK3CA‐induced hepatocarcinogenesis: new therapeutic venues by Scheiter, Alexander, Evert, Katja, Reibenspies, Lucas, Cigliano, Antonio, Annweiler, Katharina, Müller, Karolina, Pöhmerer, Laura‐Maria‐Giovanna, Xu, Hongwei, Cui, Guofei, Itzel, Timo, Materna‐Reichelt, Silvia, Coluccio, Andrea, Honarnejad, Kamran, Teufel, Andreas, Brochhausen, Christoph, Dombrowski, Frank, Chen, Xin, Evert, Matthias, Calvisi, Diego F., Utpatel, Kirsten

“…Aberrant activation of the phosphoinositide 3‐kinase (PI3K)/AKT/mTOR and Ras/mitogen‐activated protein kinase (MAPK) pathways is a hallmark of…”
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Identification and In-Depth Analysis of the Novel FGFR2-NDC80 Fusion in a Cholangiocarcinoma Patient: Implication for Therapy by Scheiter, Alexander, Keil, Felix, Lüke, Florian, Grosse, Jirka, Verloh, Niklas, Opitz, Sabine, Schlosser, Sophie, Kandulski, Arne, Pukrop, Tobias, Dietmaier, Wolfgang, Evert, Matthias, Calvisi, Diego F, Utpatel, Kirsten

“…Fibroblast growth factor receptor 2 (FGFR2) fusions have emerged as a new therapeutic target for cholangiocarcinoma in clinical practice following the United…”
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Application of A U-Net for Map-like Segmentation and Classification of Discontinuous Fibrosis Distribution in Gd-EOB-DTPA-Enhanced Liver MRI by Strotzer, Quirin David, Winther, Hinrich, Utpatel, Kirsten, Scheiter, Alexander, Fellner, Claudia, Doppler, Michael Christian, Ringe, Kristina Imeen, Raab, Florian, Haimerl, Michael, Uller, Wibke, Stroszczynski, Christian, Luerken, Lukas, Verloh, Niklas

“…We aimed to evaluate whether U-shaped convolutional neuronal networks can be used to segment liver parenchyma and indicate the degree of liver…”
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Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry by Izquierdo-Sanchez, Laura, Lamarca, Angela, La Casta, Adelaida, Buettner, Stefan, Utpatel, Kirsten, Klümpen, Heinz-Josef, Adeva, Jorge, Vogel, Arndt, Lleo, Ana, Fabris, Luca, Ponz-Sarvise, Mariano, Brustia, Raffaele, Cardinale, Vincenzo, Braconi, Chiara, Vidili, Gianpaolo, Jamieson, Nigel B., Macias, Rocio IR, Jonas, Jan Philipp, Marzioni, Marco, Hołówko, Wacław, Folseraas, Trine, Kupčinskas, Juozas, Sparchez, Zeno, Krawczyk, Marcin, Krupa, Łukasz, Scripcariu, Viorel, Grazi, Gian Luca, Landa-Magdalena, Ana, Ijzermans, Jan NM, Evert, Katja, Erdmann, Joris I., López-López, Flora, Saborowski, Anna, Scheiter, Alexander, Santos-Laso, Alvaro, Carpino, Guido, Andersen, Jesper B., Marin, Jose JG, Alvaro, Domenico, Bujanda, Luis, Forner, Alejandro, Valle, Juan W., Koerkamp, Bas Groot, Banales, Jesus M.

“…Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence and related mortality is increasing. This study investigates the clinical…”
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Identification of CD133+ intercellsomes in intercellular communication to offset intracellular signal deficit by Kaneko, Kota, Liang, Yan, Liu, Qing, Zhang, Shuo, Scheiter, Alexander, Song, Dan, Feng, Gen-Sheng

“…CD133 (prominin 1) is widely viewed as a cancer stem cell marker in association with drug resistance and cancer recurrence. Herein, we report that with…”
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Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis by Witte, Maarten E., Schumacher, Adrian-Minh, Mahler, Christoph F., Bewersdorf, Jan P., Lehmitz, Jonas, Scheiter, Alexander, Sánchez, Paula, Williams, Philip R., Griesbeck, Oliver, Naumann, Ronald, Misgeld, Thomas, Kerschensteiner, Martin

“…Axon loss determines persistent disability in multiple sclerosis patients. Here, we use in vivo calcium imaging in a multiple sclerosis model to show that…”
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Autopsy findings after long-term treatment of COVID-19 patients with microbiological correlation by Evert, Katja, Dienemann, Thomas, Brochhausen, Christoph, Lunz, Dirk, Lubnow, Matthias, Ritzka, Markus, Keil, Felix, Trummer, Matthias, Scheiter, Alexander, Salzberger, Bernd, Reischl, Udo, Boor, Peter, Gessner, André, Jantsch, Jonathan, Calvisi, Diego F., Evert, Matthias, Schmidt, Barbara, Simon, Michaela

“…Between April and June 2020, i.e., during the first wave of pandemic coronavirus disease 2019 (COVID-19), 55 patients underwent long-term treatment in the…”
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Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases by Jesinghaus, Moritz, Schmitt, Maxime, Lang, Corinna, Reiser, Marianne, Scheiter, Alexander, Konukiewitz, Björn, Steiger, Katja, Silva, Miguel, Tschurtschenthaler, Markus, Lange, Sebastian, Foersch, Sebastian, Becker, Karl F., Saur, Dieter, Friess, Helmut, Halfter, Kathrin, Engel, Jutta, Boxberg, Melanie, Pfarr, Nicole, Wilhelm, Dirk, Weichert, Wilko

“…The 2019 World Health Organization (WHO) classification of colorectal carcinoma (CRC) profoundly reclassified CRC subtypes and introduces tumor budding as a…”
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Characteristics and outcome of patients with small bowel adenocarcinoma (SBA) by Teufel, Andreas, Meindl-Beinker, Nadja M., Hösel, Pauline, Gerken, Michael, Roig, Ana, Ebert, Matthias P., Herr, Wolfgang, Scheiter, Alexander, Pauer, Armin, Schlitt, Hans J., Klinkhammer-Schalke, Monika

“…Background Small bowel adenocarcinoma (SBA) remains a rare malignancy accounting for less than 5% of all the gastrointestinal tract cancers. However, only…”
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Complex Roles of PTPN11/SHP2 in Carcinogenesis and Prospect of Targeting SHP2 in Cancer Therapy by Scheiter, Alexander, Lu, Li-Chun, Gao, Lilian H, Feng, Gen-Sheng

“…The nonreceptor tyrosine phosphatase SHP2 has been at the center of cell signaling research for three decades. SHP2 is required to fully activate the…”
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Automated breast ultrasound (ABUS) for intraoperative margin control on surgical specimens in breast conserving surgery by Hatzipanagiotou, Maria Eleni, Huber, Deborah, Thede, Elisa, Scheiter, Alexander, Fernandez-Pacheco, Miriam, Hetterich, Madeleine, Roca Ripoll, Blanca, Ortmann, Olaf, Seitz, Stephan

“…Purpose As breast-conserving surgery (BCS) has become the standard for treatment of early breast cancer, the need for new technologies to improve…”
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Critical evaluation of molecular tumour board outcomes following 2 years of clinical practice in a Comprehensive Cancer Centre by Scheiter, Alexander, Hierl, Frederik, Lüke, Florian, Keil, Felix, Heudobler, Daniel, Einhell, Sabine, Klier-Richter, Margit, Konstandin, Nikola P., Weber, Florian, Scheiter, Andrea, Kandulski, Arne, Schlosser, Sophie, Cosma, Lidia-Sabina, Tews, Hauke, Weiss, Andreas R. R., Grube, Matthias, Bumes, Elisabeth, Hau, Peter, Proescholdt, Martin, Steger, Felix, Troeger, Anja, Haferkamp, Sebastian, Reibenspies, Lucas E., Schnabel, Marco J., Schulz, Christian, Drexler, Konstantin, Hatzipanagiotou, Maria E., Seitz, Stephan, Klinkhammer-Schalke, Monika, Unberath, Philipp, Calvisi, Diego F., Pukrop, Tobias, Dietmaier, Wolfgang, Evert, Matthias, Utpatel, Kirsten

“…Background Recently, molecular tumour boards (MTBs) have been integrated into the clinical routine. Since their benefit remains debated, we assessed MTB…”
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Comparing Survival of Perihilar Cholangiocarcinoma After R1 Resection Versus Palliative Chemotherapy for Unresected Localized Disease by van Keulen, Anne-Marleen, Buettner, Stefan, Olthof, Pim B., Klümpen, Heinz-Josef, Erdmann, Joris I., Izquierdo-Sanchez, Laura, Banales, Jesus M., Goeppert, Benjamin, Roessler, Stephanie, Zieniewicz, Krzysztof, Lamarca, Angela, Valle, Juan W., La Casta, Adelaida, Hoogwater, Frederik J. H., Donadon, Matteo, Scheiter, Alexander, Marzioni, Marco, Adeva, Jorge, Kiudeliene, Edita, Fernández, Jesús María Urman, Vidili, Gianpaolo, Mocan, Tudor, Fabris, Luca, Krawczyk, Marcin, Folseraas, Trine, Dopazo, Cristina, Detry, Olivier, Voiosu, Theodor, Scripcariu, Viorel, Biancaniello, Francesca, Braconi, Chiara, Macias, Rocio I. R., Groot Koerkamp, Bas

“…Background Resection of perihilar cholangiocarcinoma (pCCA) is a complex procedure with a high risk of postoperative mortality and early disease recurrence…”
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The WERA cancer center matrix: Strategic management of patient access to precision oncology in a large and mostly rural area of Germany by Krebs, Markus, Haller, Florian, Spörl, Silvia, Gerhard-Hartmann, Elena, Utpatel, Kirsten, Maurus, Katja, Kunzmann, Volker, Chatterjee, Manik, Venkataramani, Vivek, Maatouk, Imad, Bittrich, Max, Einwag, Tatjana, Meidenbauer, Norbert, Tögel, Lars, Hirsch, Daniela, Dietmaier, Wolfgang, Keil, Felix, Scheiter, Alexander, Immel, Alexander, Heudobler, Daniel, Einhell, Sabine, Kaiser, Ulrich, Sedlmeier, Anja M., Maurer, Julia, Schenkirsch, Gerhard, Jordan, Frank, Schmutz, Maximilian, Dintner, Sebastian, Rosenwald, Andreas, Hartmann, Arndt, Evert, Matthias, Märkl, Bruno, Bargou, Ralf, Mackensen, Andreas, Beckmann, Matthias W., Pukrop, Tobias, Herr, Wolfgang, Einsele, Hermann, Trepel, Martin, Goebeler, Maria-Elisabeth, Claus, Rainer, Kerscher, Alexander, Lüke, Florian

“…Providing patient access to precision oncology (PO) is a major challenge of clinical oncologists. Here, we provide an easily transferable model from strategic…”
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Cellular Dissociation Grading Based on the Parameters Tumor Budding and Cell Nest Size in Pretherapeutic Biopsy Specimens Allows for Prognostic Patient Stratification in Esophageal Squamous Cell Carcinoma Independent From Clinical Staging by Jesinghaus, Moritz, Brühl, Frido, Steiger, Katja, Klare, Peter, Reiser, Marianne, Scheiter, Alexander, Konukiewitz, Björn, Kuhn, Peer, Münch, Stefan, Quante, Michael, Schmid, Roland M, Wilhelm, Dirk, Feith, Markus, Friess, Helmut, Combs, Stephanie E, Saur, Dieter, Boxberg, Melanie, Weichert, Wilko

“…Initial treatment planning in esophageal squamous cell carcinoma mainly relies on clinical staging. Recently, a highly prognostic grading system based on the…”
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ASO Visual Abstract: Comparing Survival of Perihilar Cholangiocarcinoma After R1 Resection Versus Palliative Chemotherapy for Unresected Localized Disease by van Keulen, Anne-Marleen, Buettner, Stefan, Olthof, Pim B., Klümpen, Heinz-Josef, Erdmann, Joris I., Izquierdo-Sanchez, Laura, Banales, Jesus M., Goeppert, Benjamin, Roessler, Stephanie, Zieniewicz, Krzysztof, Lamarca, Angela, Valle, Juan W., La Casta, Adelaida, Hoogwater, Frederik J. H., Donadon, Matteo, Scheiter, Alexander, Marzioni, Marco, Adeva, Jorge, Kiudeliene, Edita, Fernández, Jesús María Urman, Vidili, Gianpaolo, Mocan, Tudor, Fabris, Luca, Krawczyk, Marcin, Folseraas, Trine, Dopazo, Cristina, Detry, Olivier, Voiosu, Theodor, Scripcariu, Viorel, Biancaniello, Francesca, Braconi, Chiara, Macias, Rocio I. R., Groot Koerkamp, Bas

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Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance by Calvisi, Diego F., Boulter, Luke, Vaquero, Javier, Saborowski, Anna, Fabris, Luca, Rodrigues, Pedro M., Coulouarn, Cédric, Castro, Rui E., Segatto, Oreste, Raggi, Chiara, van der Laan, Luc J. W., Carpino, Guido, Goeppert, Benjamin, Roessler, Stephanie, Kendall, Timothy J., Evert, Matthias, Gonzalez-Sanchez, Ester, Valle, Juan W., Vogel, Arndt, Bridgewater, John, Borad, Mitesh J., Gores, Gregory J., Roberts, Lewis R., Marin, Jose J. G., Andersen, Jesper B., Alvaro, Domenico, Forner, Alejandro, Banales, Jesus M., Cardinale, Vincenzo, Macias, Rocio I. R., Vicent, Silve, Chen, Xin, Braconi, Chiara, Verstegen, Monique M. A., Fouassier, Laura

“…Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA has a poor prognosis, its clinical management remains…”
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