Search Results - "Scheinman, Robert I."

Functional differences in the mu opioid receptor SNP 118A>G are dependent on receptor splice‐variant and agonist‐specific recruitment of β‐arrestin by Patrick, Casey, Ettah, Utibeabasi, Nguyen, Vu, Hart, Caitlin, Atchley, Evan, Mallela, Krishna, Scheinman, Robert I., Monte, Andrew A.

“…The OPRM1 gene codes for the mu opioid receptor (MOR) and polymorphisms are associated with complex patient clinical responses. The most studied single…”
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C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice by Banda, Nirmal K, Tomlinson, Stephen, Scheinman, Robert I, Ho, Nhu, Ramirez, Joseline Ramos, Mehta, Gaurav, Wang, Guankui, Vu, Vivian Pham, Simberg, Dmitri, Kulik, Liudmila, Holers, V Michael

“…Natural IgM antibodies (NAbs) have been shown to recognize injury-associated neoepitopes and to initiate pathogenic complement activation. The NAb termed C2…”
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Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D by Holers, V Michael, Borodovsky, Anna, Scheinman, Robert I, Ho, Nhu, Ramirez, Joseline Ramos, Dobó, József, Gál, Péter, Lindenberger, Jared, Hansen, Annette G, Desai, Dhruv, Pihl, Rasmus, Thiel, Steffen, Banda, Nirmal K

“…The complement system plays an important role in the pathogenesis of rheumatoid arthritis (RA). Besides driving lectin pathway (LP) activation, the…”
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Amino acid and manganese supplementation modulates the glycosylation state of erythropoietin in a CHO culture system by Crowell, Christopher K., Grampp, Gustavo E., Rogers, Gary N., Miller, Janis, Scheinman, Robert I.

“…The manufacture of secreted proteins is complicated by the need for both high levels of expression and appropriate processing of the nascent polypeptide. For…”
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Pigmented-MDCK (P-MDCK) Cell Line with Tunable Melanin Expression: An in Vitro Model for the Outer Blood–Retinal Barrier by Kadam, Rajendra S, Scheinman, Robert. I, Kompella, Uday B

“…Retinal pigment epithelium, which forms the outer blood–retinal barrier, is a critical barrier for transport of drugs to the retina. The purpose of this study…”
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Does complement play a role in pathogenic ACPA? by Scheinman, Robert I, Banda, Nirmal K

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Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins by Li, Yue, Jacques, Sarah, Gaikwad, Hanmant, Wang, Guankui, Banda, Nirmal K., Holers, V. Michael, Scheinman, Robert I., Tomlinson, Stephen, Moghimi, S. Moein, Simberg, Dmitri

“…Effective inhibition of the complement system is needed to prevent the accelerated clearance of nanomaterials by complement cascade and inflammatory responses…”
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LEDGF(1-326) decreases P23H and wild type rhodopsin aggregates and P23H rhodopsin mediated cell damage in human retinal pigment epithelial cells by Baid, Rinku, Scheinman, Robert I, Shinohara, Toshimichi, Singh, Dhirendra P, Kompella, Uday B

“…P23H rhodopsin, a mutant rhodopsin, is known to aggregate and cause retinal degeneration. However, its effects on retinal pigment epithelial (RPE) cells are…”
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Nanoparticle-Binding Immunoglobulins Predict Variable Complement Responses in Healthy and Diseased Cohorts by Li, Yue, Saba, Laura, Scheinman, Robert I., Banda, Nirmal K., Holers, Michael, Monte, Andrew, Dylla, Layne, Moghimi, S. Moein, Simberg, Dmitri

“…Systemic administration of nanomedicines results in the activation of the complement cascade, promoting phagocytic uptake and triggering proinflammatory…”
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Feraheme (Ferumoxytol) Is Recognized by Proinflammatory and Anti-inflammatory Macrophages via Scavenger Receptor Type AI/II by Wang, Guankui, Serkova, Natalie J, Groman, Ernest V, Scheinman, Robert I, Simberg, Dmitri

“…Feraheme (ferumoxytol), a negatively charged, carboxymethyl dextran-coated ultrasmall superparamagnetic iron oxide nanoparticle (USPIO, 30 nm, −16 mV), is…”
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A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA by Mehta, Gaurav, Scheinman, Robert I, Holers, V Michael, Banda, Nirmal K

“…Rheumatoid arthritis (RA) is an inflammatory autoimmune joint disease in which the complement system plays an important role. Of the several components of…”
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Antibody-Dependent Complement Responses toward SARS-CoV‑2 Receptor-Binding Domain Immobilized on “Pseudovirus-like” Nanoparticles by Gaikwad, Hanmant, Li, Yue, Wang, Guankui, Li, Ronghui, Dai, Shaodong, Rester, Cody, Kedl, Ross, Saba, Laura, Banda, Nirmal K., Scheinman, Robert I., Patrick, Casey, Mallela, Krishna M.G., Moghimi, S. Moein, Simberg, Dmitri

“…Many aspects of innate immune responses to SARS viruses remain unclear. Of particular interest is the role of emerging neutralizing antibodies against the…”
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Functionalized STAT1 siRNA nanoparticles regress rheumatoid arthritis in a mouse model by Scheinman, Robert I, Trivedi, Ruchit, Vermillion, Sam, Kompella, Uday B

“…To develop and characterize an RGD peptide functionalized poly(lactide-co-glycolytic) acid (PLGA) nanosystem to deliver a STAT1 siRNA to joint tissues in a…”
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Partial activation precedes apoptotic death in T cells harboring an IAN gene mutation by Lang, Julie A., Kominski, Douglas, Bellgrau, Donald, Scheinman, Robert I.

“…The Biobreeding diabetes‐prone rat suffers from a profound peripheral lymphopenia and yet succumbs to a T cell‐dependent autoimmune disease. Lymphopenia…”
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Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2 by Banda, Nirmal K, Acharya, Sumitra, Scheinman, Robert I, Mehta, Gaurav, Takahashi, Minoru, Endo, Yuichi, Zhou, Wuding, Farrar, Conrad A, Sacks, Steven H, Fujita, Teizo, Sekine, Hideharu, Holers, V Michael

“…Complement plays an important role in the pathogenesis of rheumatoid arthritis. Although the alternative pathway (AP) is known to play a key pathogenic role in…”
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Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing by Banda, Nirmal K, Acharya, Sumitra, Scheinman, Robert I, Mehta, Gaurav, Coulombe, Marilyne, Takahashi, Minoru, Sekine, Hideharu, Thiel, Steffen, Fujita, Teizo, Holers, V Michael

“…The complement system is proposed to play an important role in the pathogenesis of rheumatoid arthritis (RA). The complement system mannan-binding…”
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Evaluation of Targeting Efficiency of Joints with Anticollagen II Antibodies by Lofchy, Laren A, Vu, Vivian P, Banda, Nirmal K, Ramirez, Joseline Ramos, Smith, Weston J, Gifford, Geoffrey, Gaikwad, Hanmant, Scheinman, Robert I, Simberg, Dmitri

“…Diseases of the joints affect over 10% of the world’s population, resulting in significant morbidity. There is an unmet need in strategies for specific…”
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Decay-Accelerating Factor Differentially Associates With Complement-Mediated Damage in Synovium After Meniscus Tear as Compared to Anterior Cruciate Ligament Injury by Holers, V Michael, Frank, Rachel M, Zuscik, Michael, Keeter, Carson, Scheinman, Robert I, Striebich, Christopher, Simberg, Dmitri, Clay, Michael R, Moreland, Larry W, Banda, Nirmal K

“…We have reported that anterior cruciate ligament (ACL) injury leads to the differential dysregulation of the complement system in the synovium as compared to…”
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Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage by Thakur, Ashish, Scheinman, Robert I., Rao, Vidhya R., Kompella, Uday B.

“…To determine the efficacy of pazopanib eye drops in the streptozotocin induced diabetic retinopathy rat model. A 0.5% w/v pazopanib suspension was prepared in…”
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Pleiotropic targets: the problem of shared signaling circuitry in rheumatoid arthritis disease progression and protection by Scheinman, Robert I

“…The immune response is replete with feedback control at many levels. These protective circuits are even functional within the arthritic joint, tempering…”
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