Search Results - "Scheidweiler, Karl"

Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography–tandem mass spectrometry by Scheidweiler, Karl B., Huestis, Marilyn A.

“…Clandestine laboratories constantly produce new synthetic cannabinoids to circumvent legislative efforts, complicating toxicological analysis. No extensive…”
Get full text

Free and Glucuronide Whole Blood Cannabinoids' Pharmacokinetics after Controlled Smoked, Vaporized, and Oral Cannabis Administration in Frequent and Occasional Cannabis Users: Identification of Recent Cannabis Intake by Newmeyer, Matthew N, Swortwood, Madeleine J, Barnes, Allan J, Abulseoud, Osama A, Scheidweiler, Karl B, Huestis, Marilyn A

“…There is increasing interest in markers of recent cannabis use because following frequent cannabis intake, Δ -tetrahydrocannabinol (THC) may be detected in…”
Get full text

Distinguishing Intake of New Synthetic Cannabinoids ADB-PINACA and 5F-ADB-PINACA with Human Hepatocyte Metabolites and High-Resolution Mass Spectrometry by Carlier, Jeremy, Diao, Xingxing, Scheidweiler, Karl B, Huestis, Marilyn A

“…ADB-PINACA and its 5-fluoropentyl analog 5F-ADB-PINACA are among the most potent synthetic cannabinoids tested to date, with several severe intoxication cases…”
Get full text

Qualitative Confirmation of 9 Synthetic Cannabinoids and 20 Metabolites in Human Urine Using LC–MS/MS and Library Search by Wohlfarth, Ariane, Scheidweiler, Karl B, Chen, Xiaohong, Liu, Hua-fen, Huestis, Marilyn A

“…Introduction: Synthetic cannabinoids are an emerging illicit drug class. The variety of available substances is large and ever-changing, making it difficult…”
Get full text

High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes by Diao, Xingxing, Wohlfarth, Ariane, Pang, Shaokun, Scheidweiler, Karl B, Huestis, Marilyn A

“…Despite increasing prevalence of novel psychoactive substances, no human metabolism data are currently available, complicating laboratory documentation of…”
Get full text

Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry by Wohlfarth, Ariane, Gandhi, Adarsh S., Pang, Shaokun, Zhu, Mingshe, Scheidweiler, Karl B., Huestis, Marilyn A.

“…Background PB-22 (1-pentyl-8-quinolinyl ester-1H-indole-3-carboxylic acid) and 5F-PB-22 (1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid) are…”
Get full text

Metabolic profiling of new synthetic cannabinoids AMB and 5F-AMB by human hepatocyte and liver microsome incubations and high-resolution mass spectrometry by Andersson, Maria, Diao, Xingxing, Wohlfarth, Ariane, Scheidweiler, Karl B., Huestis, Marilyn A.

“…Rationale AMB (methyl (1‐pentyl‐1H‐indazole‐3‐carbonyl)‐L‐valinate)) and its fluoro analog 5F‐AMB (methyl…”
Get full text

Nontargeted SWATH acquisition for identifying 47 synthetic cannabinoid metabolites in human urine by liquid chromatography-high-resolution tandem mass spectrometry by Scheidweiler, Karl B., Jarvis, Michael J. Y., Huestis, Marilyn A.

“…Clandestine laboratories constantly produce new synthetic cannabinoids to circumvent legislative scheduling efforts, challenging and complicating toxicological…”
Get full text

Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA by Wohlfarth, Ariane, Castaneto, Marisol S., Zhu, Mingshe, Pang, Shaokun, Scheidweiler, Karl B., Kronstrand, Robert, Huestis, Marilyn A.

“…Whereas non-fluoropentylindole/indazole synthetic cannabinoids appear to be metabolized preferably at the pentyl chain though without clear preference for one…”
Get full text

Phase I and II cannabinoid disposition in blood and plasma of occasional and frequent smokers following controlled smoked cannabis by Desrosiers, Nathalie A, Himes, Sarah K, Scheidweiler, Karl B, Concheiro-Guisan, Marta, Gorelick, David A, Huestis, Marilyn A

“…Δ(9)-Tetrahydrocannabinol (THC), 11-hydroxy-THC (11-OH-THC), and 11-nor-9-carboxy-THC (THCCOOH) have been reported in blood from frequent cannabis smokers for…”
Get full text

Simultaneous quantification of 11 cannabinoids and metabolites in human urine by liquid chromatography tandem mass spectrometry using WAX-S tips by Andersson, Maria, Scheidweiler, Karl B., Sempio, Cristina, Barnes, Allan J., Huestis, Marilyn A.

“…A comprehensive cannabinoid urine quantification method may improve clinical and forensic result interpretation and is necessary to support our clinical…”
Get full text

In Vitro and In Vivo Human Metabolism of Synthetic Cannabinoids FDU-PB-22 and FUB-PB-22 by Diao, Xingxing, Scheidweiler, Karl B., Wohlfarth, Ariane, Pang, Shaokun, Kronstrand, Robert, Huestis, Marilyn A.

“…In 2014, FDU-PB-22 and FUB-PB-22, two novel synthetic cannabinoids, were detected in herbal blends in Japan, Russia, and Germany and were quickly added to…”
Get full text

Direct quantification of cannabinoids and cannabinoid glucuronides in whole blood by liquid chromatography–tandem mass spectrometry by Schwope, David M., Scheidweiler, Karl B., Huestis, Marilyn A.

“…The first method for quantifying cannabinoids and cannabinoid glucuronides in whole blood by liquid chromatography–tandem mass spectrometry (LC–MS/MS) was…”
Get full text

First metabolic profile of XLR-11, a novel synthetic cannabinoid, obtained by using human hepatocytes and high-resolution mass spectrometry by Wohlfarth, Ariane, Pang, Shaokun, Zhu, Mingshe, Gandhi, Adarsh S, Scheidweiler, Karl B, Liu, Hua-fen, Huestis, Marilyn A

“…Since the mid-2000s synthetic cannabinoids have been abused as recreational drugs, prompting scheduling of these substances in many countries. To circumvent…”
Get full text

Quantification of cannabinoids and their free and glucuronide metabolites in whole blood by disposable pipette extraction and liquid chromatography-tandem mass spectrometry by Scheidweiler, Karl B., Newmeyer, Matthew N., Barnes, Allan J., Huestis, Marilyn A.

“…•Quantification of multiple blood cannabinoids improves results interpretation.•Disposable pipette extraction allows for sensitive cannabinoid…”
Get full text

Cannabinoid disposition in oral fluid after controlled smoked, vaporized, and oral cannabis administration by Swortwood, Madeleine J., Newmeyer, Matthew N., Andersson, Maria, Abulseoud, Osama A., Scheidweiler, Karl B., Huestis, Marilyn A.

“…Oral fluid (OF) is an important matrix for monitoring drugs. Smoking cannabis is common, but vaporization and edible consumption also are popular. OF…”
Get full text

Impact of prolonged cannabinoid excretion in chronic daily cannabis smokers' blood on per se drugged driving laws by Bergamaschi, Mateus M, Karschner, Erin L, Goodwin, Robert S, Scheidweiler, Karl B, Hirvonen, Jussi, Queiroz, Regina H C, Huestis, Marilyn A

“…Cannabis is the illicit drug most frequently reported with impaired driving and motor vehicle accidents. Some "per se" laws make it illegal to drive with any…”
Get full text

Simultaneous quantification of free and glucuronidated cannabinoids in human urine by liquid chromatography tandem mass spectrometry by Scheidweiler, Karl B., Desrosiers, Nathalie A., Huestis, Marilyn A.

“…Cannabis is the most commonly abused drug of abuse and is commonly quantified during urine drug testing. We are conducting a controlled drug administration…”
Get full text

Quantification of Eight Cannabinoids Including Cannabidiol in Human Urine Via Liquid Chromatography Tandem Mass Spectrometry by Scheidweiler, Karl B, Barnes, Allan J

“…Medical and recreational cannabis legalization has highlighted the importance of being able to identify recent cannabis use and impairment. Monitoring minor…”
Get more information

In Vitro Metabolite Profiling of ADB-FUBINACA, A New Synthetic Cannabinoid by Carlier, Jeremy, Diao, Xingxing, Wohlfarth, Ariane, Scheidweiler, Karl, Huestis, Marilyn A

“…Background: Metabolite profiling of novel psychoactive substances (NPS) is critical for documenting drug consumption…”
Get full text