An experimental comparative study on the characteristics of ventricular fibrillation during cardiac arrest and methoxamine administration

The effect of a pure alpha-adrenergic agent, methoxamine on ventricular fibrillation (VF) amplitude and the relation between hemodynamic parameters and survival in a rodent cardiopulmonary resuscitation (CPR) model were studied. Our results suggested that: 1) VF amplitude decreased during untreated...

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Bibliographic Details
Published in:	Current medical science Vol. 17; no. 2; pp. 94 - 97
Main Authors:	Pan, T, Chau, S, Von Planta, M, Studer, W, Scheidgger, D
Format:	Journal Article
Language:	English
Published:	China 1997
Subjects:	Adrenergic alpha-Agonists - pharmacology Animals Cardiopulmonary Resuscitation Electric Countershock Heart Arrest - physiopathology Male Methoxamine - pharmacology Rats Rats, Sprague-Dawley Ventricular Fibrillation - physiopathology
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Summary:	The effect of a pure alpha-adrenergic agent, methoxamine on ventricular fibrillation (VF) amplitude and the relation between hemodynamic parameters and survival in a rodent cardiopulmonary resuscitation (CPR) model were studied. Our results suggested that: 1) VF amplitude decreased during untreated VF, but it increased during pericardial chest compression: 2) methoxamine significantly increased the mean aortic pressure (MAP) and coronary perfusion pressure (CPP) but not VF amplitude, and the survival also increased due to elevation of CPP; and 3) all surviving animals with successful defibrillation had a higher VF amplitude.
ISSN:	0257-716X 2096-5230 2523-899X
DOI:	10.1007/bf02888243