Search Results - "Schefold, J. C."

Prospectively assessed changes in lamotrigine-concentration in women with epilepsy during pregnancy, lactation and the neonatal period by Fotopoulou, Christina, Kretz, Rebekka, Bauer, Steffen, Schefold, J.C, Schmitz, Bettina, Dudenhausen, Joachim W, Henrich, Wolfgang

“…Summary Purpose To prospectively analyse the pharmacokinetics of lamotrigine (LTG) during pregnancy and lactation in a consecutive series of epileptic pregnant…”
Get full text

Dysphagia in COVID‐19 –multilevel damage to the swallowing network? by Dziewas, R., Warnecke, T., Zürcher, P., Schefold, J. C.

Get full text

Immunological mechanisms to establish embryo tolerance in early bovine pregnancy by Groebner, A E, Schulke, K, Schefold, J C, Fusch, G, Sinowatz, F, Reichenbach, H D, Wolf, E, Meyer, H H D, Ulbrich, S E

“…A well-balanced immunological interaction between mother and the semi-allogenic embryo is of particular importance. The objective of the present study was to…”
Get more information

Elevated Levels of Asymmetric Dimethylarginine in Chronic Heart Failure: A Pathophysiologic Link Between Oxygen Radical Load and Impaired Vasodilator Capacity and the Therapeutic Effect of Allopurinol by Haehling, S, Bode‐Böger, S M, Martens‐Lobenhoffer, J, Rauchhaus, M, Schefold, J C, Genth‐Zotz, S, Karhausen, T, Cicoira, M, Anker, S D, Doehner, W

“…Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide–dependent vasodilation. In 113 patients with chronic heart failure (CHF) and 26…”
Get full text

Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients by ZEDEN, J.-P, FUSCH, G, HOLTFRETER, B, SCHEFOLD, J. C, REINKE, P, DOMANSKA, G, HAAS, J.-P, GRUENDLING, M, WESTERHOLT, A, SCHUETT, C

“…It has recently been shown that an increased plasma level of the tryptophan catabolite kynurenine is an early indicator for the development of sepsis in major…”
Get full text

Psychological symptoms in relatives of critically ill patients (ICU families): a prospective multicenter study by Hoffmann, M., Jeitziner, M.-M., Riedl, R., Eller, P., Amrein, K.

Get full text

Effects of sodium bicarbonate infusion on mortality in medical–surgical ICU patients with metabolic acidosis—A single-center propensity score matched analysis by Waskowski, J., Hess, B., Cioccari, L., Irincheeva, I., Pfortmueller, C.A., Schefold, J.C.

“…Metabolic acidosis is associated with high mortality. Despite theoretical benefits of sodium-bicarbonate (SB), current evidence remains controversial. We…”
Get full text

Stress ulcer prophylaxis in the intensive care unit trial: detailed statistical analysis plan by Krag, M., Perner, A., Wetterslev, J., Lange, T., Wise, M. P., Borthwick, M., Bendel, S., Pelosi, P., Keus, F., Guttormsen, A. B., Schefold, J. C., Meyhoff, T. S., Marker, S., Møller, M. H.

“…Background In this statistical analysis plan, we aim to provide details of the pre‐defined statistical analyses of the Stress Ulcer Prophylaxis in the…”
Get full text

Prophylactic use of tranexamic acid in noncardiac surgery : Update 2017 by Waskowski, J, Schefold, J C, Stueber, F

“…Minimising perioperative bleeding is a key goal of "patient blood management" programs. One component of respective strategies includes preventive inhibition…”
Get full text

Amelioration of anemia after kidney transplantation in severe secondary oxalosis by Bernhardt, W M, Schefold, J C, Weichert, W, Rudolph, B, Frei, U, Groneberg, D A, Schindler, R

“…In small bowel disease such as M. Crohn, the intestinal absorption of oxalate is increased. Severe calcium oxalate deposition in multiple organs as consequence…”
Get more information

Timing of onset of gastrointestinal bleeding in the ICU: Protocol for a preplanned observational study by Granholm, A., Lange, T., Anthon, C. T., Marker, S., Krag, M., Meyhoff, T. S., Wise, M. P., Borthwick, M., Bendel, S., Keus, F., Guttormsen, A. B., Schefold, J. C., Wetterslev, J., Perner, A., Møller, M. H.

“…Background Critically ill patients are at risk of gastrointestinal bleeding, but clinically important gastrointestinal bleeding is rare. The majority of…”
Get full text

qSOFA score not predictive of in-hospital mortality in emergency patients with decompensated liver cirrhosis by Müller, M., Schefold, J. C., Leichtle, A. B., Srivastava, D., Lindner, G., Exadaktylos, A. K., Pfortmueller, C. A.

“…Background Quick sequential organ failure assessement (qSOFA) has been validated for patients with presumed sepsis and the general emergency department (ED)…”
Get full text

Effects of dialysis modality on blood loss, bleeding complications and transfusion requirements in critically ill patients with dialysis-dependent acute renal failure by Pschowski, R, Briegel, S, Von Haehling, S, Doehner, W, Bender, T O, Pape, U F, Hasper, D, Jörress, A, Schefold, J C

“…Blood loss and bleeding complications may often be observed in critically ill patients on renal replacement therapies (RRT). Here we investigate procedural…”
Get full text

Adsorption therapy in sepsis by Hasper, D, Schefold, J C, Jörres, A

“…The activation of multiple pro- and anti-inflammatory mediators is a key feature in the pathophysiology of sepsis. Many of these mediators may directly…”
Get full text

Tympanic temperature during therapeutic hypothermia by Hasper, D, Nee, J, Schefold, J C, Krueger, A, Storm, C

“…Prehospital induction of therapeutic hypothermia after cardiac arrest may require temperature monitoring in the field. Tympanic temperature is non-invasive and…”
Get more information

The impact of pre-existing chronic heart failure on the intensive care treatment and outcome of old intensive care patients suffering from COVID-19 by Bruno, R R, Wernly, B, Wolff, G, Artigas, A, Pinto, B B, Schefold, J C, Kindgen-Milles, D, Baldia, P H, Kelm, M, Beil, M, Leaver, S, De Lange, D W, Guidet, B, Flaatten, H, Jung, C

“…Abstract Background Patients suffering from COVID-19 with pre-existing chronic heart failure (CHF) are considered to have a significant risk regarding…”
Get full text

Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms by Schefold, Jörg C., Zeden, Jan-Philip, Fotopoulou, Christina, von Haehling, Stephan, Pschowski, Rene, Hasper, Dietrich, Volk, Hans-Dieter, Schuett, Christine, Reinke, Petra

“…Background. Tryptophan (Trp) is catabolized by indoleamine 2,3-dioxygenase (IDO). Changes in Trp metabolism and IDO activity in chronic kidney disease (CKD)…”
Get full text

Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study by Fronczek, Jakub, Polok, Kamil, de Lange, Dylan W., Jung, Christian, Beil, Michael, Rhodes, Andrew, Fjølner, Jesper, Górka, Jacek, Andersen, Finn H., Artigas, Antonio, Cecconi, Maurizio, Christensen, Steffen, Joannidis, Michael, Leaver, Susannah, Marsh, Brian, Morandi, Alessandro, Moreno, Rui, Oeyen, Sandra, Agvald-Öhman, Christina, Bollen Pinto, Bernardo, Schefold, Joerg C., Valentin, Andreas, Walther, Sten, Watson, Ximena, Zafeiridis, Tilemachos, Sviri, Sigal, van Heerden, Peter Vernon, Flaatten, Hans, Guidet, Bertrand, Szczeklik, Wojciech, Schmutz, R., Wimmer, F., Eller, P., Joannidis, M., De Buysscher, P., De Neve, N., Oeyen, S., Swinnen, W., Bollen Pinto, B., Abraham, P., Hergafi, L., Schefold, J. C., Biskup, E., Piza, P., Taliadoros, I., Fjølner, J., Dey, N., Sølling, C., Rasmussen, B. S., Christensen, S., Forceville, X., Besch, G., Mentec, H., Michel, P., Mateu, P., Vettoretti, L., Bourenne, J., Marin, N., Guillot, M., Aissaoui, N., Goulenok, C., Thieulot-Rolin, N., Messika, J., Lamhaut, L., Guidet, B., Charron, C., Lauten, A., Sacher, A. L., Brenner, T., Franz, M., Bloos, F., Ebelt, H., Schaller, S. J., Fuest, K., Rabe, C., Dieck, T., Steiner, S., Graf, T., Nia, A. M., Jung, C., Janosi, R. A., Meybohm, P., Simon, P., Utzolino, S., Rahmel, T., Barth, E., Schuster, M., Aidoni, Z., Aloizos, S., Tasioudis, P., Lampiri, K., Zisopoulou, V., Ravani, I., Pagaki, E., Antoniou, A., Katsoulas, T. A., Kounougeri, A., Marinakis, G., Tsimpoukas, F., Spyropoulou, A.

“…Abstract Background The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to…”
Get full text

The impact of religion on changes in end-of-life practices in European intensive care units: a comparative analysis over 16 years by Schefold, Joerg C., Ruzzante, Livio, Sprung, Charles L., Gruber, Anastasiia, Soreide, Eldar, Cosgrove, Joseph, Mullick, Sudakshina, Papathanakos, Georgios, Koulouras, Vasilios, Maia, Paulo Azevedo, Ricou, Bara, Posch, Martin, Metnitz, Philipp, Bülow, Hans-Henrik, Avidan, Alexander

“…Purpose Religious beliefs affect end-of-life practices in intensive care units (ICUs). Changes over time in end-of-life practices were not investigated…”
Get full text

1200Body weight changes and incidence of cachexia after stroke by Scherbakov, N, Pietrock, C, Sandek, A, Ebner, N, Valentova, M, Fiebach, J B, Schefold, J C, Von Haehling, S, Anker, S D, Norman, K, Haeusler, K G, Doehner, W

Get full text