Search Results - "Schecter, Robyn L."

Modulation of Glutathione S-Transferase Alpha by Hepatitis B Virus and the Chemopreventive Drug Oltipraz by Jaitovitch-Groisman, Iris, Fotouhi-Ardakani, Nasser, Schecter, Robyn L., Woo, Annie, Alaoui-Jamali, Moulay A., Batist, Gerald

“…Persistent infection by hepatitis B virus (HBV) and exposure to chemical carcinogens correlates with the prevalence of hepatocellular carcinoma in endemic…”
Get full text

Retrovirus-mediated gene transfer of rat glutathione S-transferase Yc confers alkylating drug resistance in NIH 3T3 mouse fibroblasts by GREENBAUM, M, LETOURNEAU, S, HOMA ASSAR, SCHECTER, R. L, BATIST, G, COURNOYER, D

“…A major limitation to successful cancer treatment is the existence of drug resistance. While several mechanisms of drug resistance have now been well…”
Get full text

In vivo and in vitro mechanisms of drug resistance in a rat mammary carcinoma model by SCHECTER, R. L, WOO, A, MINH DUONG, BATIST, G

“…Many in vitro tumor models have been examined to help understand the precise mechanisms responsible for drug resistance. The importance of these results in…”
Get full text

Glutathione S-transferase in chemotherapy resistance and in carcinogenesis by Schecter, R L, Alaoui-Jamali, M A, Batist, G

“…Cytosolic glutathione S-transferases are composed of two monomeric subunits. These monomers are the products of different gene families designated alpha, mu,…”
Get more information

Evidence for genomic duplication of the glutathione transferase A3 gene in genus Rattus by Fotouhi-Ardakani, N, Schecter, R L, Batist, G

Get full text

Characterization of 5-oxo-L-prolinase in normal and tumor tissues of humans and rats: a potential new target for biochemical modulation of glutathione by CHEN, X, SCHECTER, R. L, GRIFFITH, O. W, HAYWARD, M. A, ALPERT, L. C, BATIST, G

“…5-Oxo-L-prolinase (5-OPase) is an enzyme of the gamma-glutamyl cycle involved in the synthesis and metabolism of glutathione (GSH), which is known to protect…”
Get full text

Expression of a rat glutathione-S-transferase complementary DNA in rat mammary carcinoma cells : impact upon alkylator-induced toxicity by SCHECTER, R. L, ALAOUI-JAMALI, M. A, WOO, A, FAHL, W. E, BATIST, G

“…The role of glutathione-S-transferase (GST) in alkylator drug resistance has been studied in MatB rat mammary carcinoma cells. A series of GST transfectant…”
Get full text

Relation of glutathione S-transferase alpha and mu isoforms to response to therapy in human breast cancer by ALPERT, L. C, SCHECTER, R. L, BERRY, D. A, MELNYCHUK, D, PETERS, W. P, CARUSO, J. A, TOWNSEND, A. J, BATIST, G

“…Glutathione S-transferase (GST) represents a multifunctional enzyme family consisting of four known cytosolic isoforms (alpha, mu, pi, and Phi) that detoxify a…”
Get full text

Modulation of glutathione by a cysteine pro-drug enhances in vivo tumor response by Wang, T, Chen, X, Schecter, R L, Baruchel, S, Alaoui-Jamali, M, Melnychuk, D, Batist, G

“…Glutathione (GSH) is known to play a role in cellular sensitivity to some chemotherapeutic agents and to radiation. Depletion of cellular glutathione increases…”
Get more information

Mechanisms of Tumor Cell Drug Resistance: The Role of Glutathione-S-Transferase in Mammary Adenocarcinoma Cells by Schecter, Robyn L

“…The development of resistance of malignant tumors to the chemotherapeutic agents used in the treatment of neoplastic disease is a major factor responsible for…”
Get full text