Search Results - "Schechter, N M"

Two Types of Human Mast Cells That Have Distinct Neutral Protease Compositions by Irani, A. A., Schechter, N. M., Craig, S. S., DeBlois, G., Schwartz, L. B.

“…Two human mast cell types were identified by immunohistochemical techniques in skin, lung, and small intestine. One type contains the neutral proteases,…”
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The Serpin MNEI Inhibits Elastase-like and Chymotrypsin-like Serine Proteases through Efficient Reactions at Two Active Sites by Cooley, Jessica, Takayama, Thomas K, Shapiro, Steven D, Schechter, Norman M, Remold-O'Donnell, Eileen

“…MNEI (monocyte/neutrophil elastase inhibitor) is a 42 kDa serpin superfamily protein characterized initially as a fast-acting inhibitor of neutrophil elastase…”
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Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti- chymase antibodies by Irani, AM, Bradford, TR, Kepley, CL, Schechter, NM, Schwartz, LB

“…We developed an improved immunohistochemical technique for distinguishing human mast cells of the MCT (tryptase-positive, chymase-negative) and MCTC…”
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Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells by Schwartz, LB, Irani, AM, Roller, K, Castells, MC, Schechter, NM

“…Levels of histamine, chymase, and tryptase were assessed in preparations of dispersed human TC (tryptase+, chymase+) mast cells obtained from foreskin and of…”
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Identification of a cathepsin G-like proteinase in the MCTC type of human mast cell by Schechter, NM, Irani, AM, Sprows, JL, Abernethy, J, Wintroub, B, Schwartz, LB

“…Human mast cells can be divided into two subsets based on serine proteinase composition: a subset that contains the serine proteinases tryptase and chymase…”
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Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors by Schechter, N M, Sprows, J L, Schoenberger, O L, Lazarus, G S, Cooperman, B S, Rubin, H

“…The ability of plasma proteinase inhibitors to inactivate human chymase, a chymotrypsin-like proteinase stored within mast cell secretory granules, was…”
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Ultrastructural analysis of human T and TC mast cells identified by immunoelectron microscopy by Craig, S S, Schechter, N M, Schwartz, L B

“…Tryptase and chymase were localized in human mast cells by immunoelectron microscopy, enabling the T (tryptase positive, chymase negative) and TC (tryptase…”
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Early cellular events in evolving cutaneous delayed hypersensitivity in humans by Waldorf, HA, Walsh, LJ, Schechter, NM, Murphy, GF

“…The delayed-type hypersensitivity reaction (DHR) in human skin is prototypic for many inflammatory dermatoses. However the cellular events that precede gross…”
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Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold by Groutas, William C., Schechter, Norman M., He, Shu, Yu, Hongyi, Huang, Peng, Tu, Juan

“…A series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold was synthesized and shown to be highly effective inhibitors of…”
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Serine proteinases are regionally segregated within mast cell granules by Whitaker-Menezes, D, Schechter, N M, Murphy, G F

“…By ultrastructure, human skin mast cell granules exhibit amorphous regions situated next to crystalline regions with scroll, lamellar, and grating/lattice-like…”
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Deficiency of the tryptase-positive, chymase-negative mast cell type in gastrointestinal mucosa of patients with defective T lymphocyte function by Irani, AM, Craig, SS, DeBlois, G, Elson, CO, Schechter, NM, Schwartz, LB

“…The distribution and concentration of human T (tryptase-positive, chymase-negative) and TC (tryptase-positive, chymase-positive) mast cells were examined in…”
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Human skin chymotrypsin-like proteinase chymase. Subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans by Sayama, S, Iozzo, R V, Lazarus, G S, Schechter, N M

“…The subcellular localization of human skin chymase to mast cell granules was established by immunoelectron microscopy, and binding of chymase to the area of…”
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Antichymotrypsin interaction with chymotrypsin. Partitioning of the complex by Cooperman, B S, Stavridi, E, Nickbarg, E, Rescorla, E, Schechter, N M, Rubin, H

“…The interactions of bovine pancreatic chymotrypsin (Chtr) and recombinant alpha 1-antichymotrypsin (rACT) and rACT variants were studied by kinetic and gel…”
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Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases by Reilly, C F, Tewksbury, D A, Schechter, N M, Travis, J

“…Human neutrophil cathepsin G and human skin mast cell chymase rapidly convert angiotensin I to angiotensin II with only minor cleavage elsewhere in the…”
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Cutaneous mast cell depletion results from topical corticosteroid usage by Lavker, RM, Schechter, NM

“…The effect of long-term topical application of corticosteroids on human cutaneous mast cells was examined. Two potent corticosteroids, clobetasol-17-propionate…”
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Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus substrate properties by Schechter, N M, Jordan, L M, James, A M, Cooperman, B S, Wang, Z M, Rubin, H

“…Inhibition of human chymase by alpha 1-antichymotrypsin produces 3.5 mol of degraded inhibitor for every mol of chymase inhibited, resulting in a stoichiometry…”
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Degradation of the epidermal-dermal junction by proteolytic enzymes from human skin and human polymorphonuclear leukocytes by BRIGGAMAN, R. A, SCHECHTER, N. M, FRAKI, J, LAZARUS, G. S

“…The degradation of normal human skin by the human polymorphonuclear leukocyte proteinases cathepsin G and elastase, and by a human skin chymotrypsin-like…”
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Ultrastructural analysis of maturing human T and TC mast cells in situ by Craig, S S, Schechter, N M, Schwartz, L B

“…Mast cells at immature stages of development were identified in human tissues by electron microscopic techniques. General morphologic criteria of immaturity…”
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Identification of a chymotrypsin-like proteinase in human mast cells by Schechter, NM, Choi, JK, Slavin, DA, Deresienski, DT, Sayama, S, Dong, G, Lavker, RM, Proud, D, Lazarus, GS

“…An antiserum was produced against a chymotryptic proteinase purified from human skin. The antiserum did not cross-react with human leukocyte cathepsin G and…”
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Human skin tryptase: Kinetic characterization of its spontaneous inactivation by Schechter, Norman M, Eng, Grace Y, McCaslin, Darrell R

“…The spontaneous loss of human tryptase hydrolytic activity was investigated. Time course studies monitoring the loss in catalytic activity were biphasic and…”
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