Search Results - "Schaub, Andrew J."

Molecular basis for interactions between an acyl carrier protein and a ketosynthase by Milligan, Jacob C., Lee, D. John, Jackson, David R., Schaub, Andrew J., Beld, Joris, Barajas, Jesus F., Hale, Joseph J., Luo, Ray, Burkart, Michael D., Tsai, Shiou-Chuan

“…Fatty acid synthases are dynamic ensembles of enzymes that can biosynthesize long hydrocarbon chains efficiently. Here we visualize the interaction between the…”
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Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain by Kwon, Young D, Pegu, Amarendra, Yang, Eun Sung, Zhang, Baoshan, Bender, Michael F, Asokan, Mangaiarkarasi, Liu, Qingbo, McKee, Krisha, Lin, Bob C, Liu, Tracy, Louder, Mark K, Rawi, Reda, Reveiz, Mateo, Schaub, Andrew J, Shen, Chen-Hsiang, Doria-Rose, Nicole A, Lusso, Paolo, Mascola, John R, Kwong, Peter D

“…The amino-acid composition of the immunoglobulin variable region has been observed to impact antibody pharmacokinetics (PK). Here, we sought to improve the PK…”
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Modeling Linear and Cyclic PKS Intermediates through Atom Replacement by Shakya, Gaurav, Rivera, Heriberto, Lee, D. John, Jaremko, Matt J, La Clair, James J, Fox, Daniel T, Haushalter, Robert W, Schaub, Andrew J, Bruegger, Joel, Barajas, Jesus F, White, Alexander R, Kaur, Parminder, Gwozdziowski, Emily R, Wong, Fiona, Tsai, Shiou-Chuan, Burkart, Michael D

“…The mechanistic details of many polyketide synthases (PKSs) remain elusive due to the instability of transient intermediates that are not accessible via…”
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Development of a Pantetheine Force Field Library for Molecular Modeling by Zhao, Shiji, Schaub, Andrew J, Tsai, Shiou-Chuan, Luo, Ray

“…Pantetheine is ubiquitous in nature in various forms of pantetheine-containing ligands (PCLs), including coenzyme A and phosphopantetheine. Lack of scalable…”
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Approaches for assessing performance of high-resolution mass spectrometry–based non-targeted analysis methods by Fisher, Christine M., Peter, Katherine T., Newton, Seth R., Schaub, Andrew J., Sobus, Jon R.

“…Non-targeted analysis (NTA) using high-resolution mass spectrometry has enabled the detection and identification of unknown and unexpected compounds of…”
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Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase by Lederhofer, Julia, Tsybovsky, Yaroslav, Nguyen, Lam, Raab, Julie E, Creanga, Adrian, Stephens, Tyler, Gillespie, Rebecca A, Syeda, Hubza Z, Fisher, Brian E, Skertic, Michelle, Yap, Christina, Schaub, Andrew J, Rawi, Reda, Kwong, Peter D, Graham, Barney S, McDermott, Adrian B, Andrews, Sarah F, King, Neil P, Kanekiyo, Masaru

“…Continuously evolving influenza viruses cause seasonal epidemics and pose global pandemic threats. Although viral neuraminidase (NA) is an effective drug and…”
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Computational structural enzymology methodologies for the study and engineering of fatty acid synthases, polyketide synthases and nonribosomal peptide synthetases by Schaub, Andrew J, Moreno, Gabriel O, Zhao, Shiji, Truong, Hau V, Luo, Ray, Tsai, Shiou-Chuan

“…Various computational methodologies can be applied to enzymological studies on enzymes in the fatty acid, polyketide, and non-ribosomal peptide biosynthetic…”
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Nontargeted Analysis of Face Masks: Comparison of Manual Curation to Automated GCxGC Processing Tools by Favela, Kristin A, Hartnett, Michael J, Janssen, Jake A, Vickers, David W, Schaub, Andrew J, Spidle, Heath A, Pickens, Keith S

“…Masks constructed of a variety of materials are in widespread use due to the COVID-19 pandemic, and people are exposed to chemicals inherent in the masks…”
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Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide by Reveiz, Mateo, Xu, Kai, Lee, Myungjin, Wang, Shuishu, Olia, Adam S., Harris, Darcy R., Liu, Kevin, Liu, Tracy, Schaub, Andrew J., Stephens, Tyler, Wang, Yiran, Zhang, Baoshan, Huang, Rick, Tsybovsky, Yaroslav, Kwong, Peter D., Rawi, Reda

“…Broadly neutralizing antibodies have been proposed as templates for HIV-1 vaccine design, but it has been unclear how similar vaccine-elicited antibodies are…”
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Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis by Jackson, David R., Tu, Stephanie S., Nguyen, MyChi, Barajas, Jesus F., Schaub, Andrew J., Krug, Daniel, Pistorius, Dominik, Luo, Ray, Müller, Rolf, Tsai, Shiou-Chuan

“…The incorporation of nonacetate starter units during type II polyketide biosynthesis helps diversify natural products. Currently, there are few enzymatic…”
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Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols by Barajas, Jesus F., Phelan, Ryan M., Schaub, Andrew J., Kliewer, Jaclyn T., Kelly, Peter J., Jackson, David R., Luo, Ray, Keasling, Jay D., Tsai, Shiou-Chuan

“…The terminal reductase (R) domain from the non-ribosomal peptide synthetase (NRPS) module MxaA in Stigmatella aurantiaca Sga15 catalyzes a non-processive…”
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Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain by Kwon, Young D., Pegu, Amarendra, Yang, Eun Sung, Zhang, Baoshan, Bender, Michael F., Asokan, Mangaiarkarasi, Liu, Qingbo, McKee, Krisha, Lin, Bob C., Liu, Tracy, Louder, Mark K., Rawi, Reda, Reveiz, Mateo, Schaub, Andrew J., Shen, Chen-Hsiang, Doria-Rose, Nicole A., Lusso, Paolo, Mascola, John R., Kwong, Peter D.

“…The amino-acid composition of the immunoglobulin variable region has been observed to impact antibody pharmacokinetics (PK). Here, we sought to improve the PK…”
Get full text

Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols by Barajas, Jesus F., Phelan, Ryan M., Schaub, Andrew J., Kliewer, Jaclyn T., Kelly, Peter J., Jackson, David R., Luo, Ray, Keasling, Jay D., Tsai, Shiou-Chuan

“…Here, the terminal reductase (R) domain from the non-ribosomal peptide synthetase (NRPS) module MxaA in Stigmatella aurantiaca Sga15 catalyzes a non-processive…”
Get full text