Search Results - "Schatzberg"

HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition by Keller, J, Gomez, R, Williams, G, Lembke, A, Lazzeroni, L, Murphy, G M, Schatzberg, A F

“…The hypothalamic–pituitary–adrenal (HPA) axis has been implicated in the pathophysiology of a variety of mood and cognitive disorders. Neuroendocrine studies…”
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Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression by Bernard, R, Kerman, I A, Thompson, R C, Jones, E G, Bunney, W E, Barchas, J D, Schatzberg, A F, Myers, R M, Akil, H, Watson, S J

“…Several studies have proposed that brain glutamate signaling abnormalities and glial pathology have a role in the etiology of major depressive disorder (MDD)…”
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Understanding the Efficacy and Mechanism of Action of a Dextromethorphan-Bupropion Combination: Where Does It Fit in the NMDA Versus mu-Opioid Story? by Schatzberg, Alan F.

“…Schatzberg discusses the report from Tabuteau et al which indicates that the combination of 90 mg of dextromethorphan and 210 mg of bupropion (AXS-05) is…”
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Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders? by Sanacora, Gerard, Schatzberg, Alan F

“…Large 'real world' studies demonstrating the limited effectiveness and slow onset of clinical response associated with our existing antidepressant medications…”
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Mechanisms of Action of Ketamine and Esketamine by Schatzberg, Alan F

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Historiography: Why Should Historians Pay More Attention to Philosophy of Technology? by Schatzberg, Eric

“…The Oxford Handbook of Philosophy of Technology marks the maturity of the philosophy of technology, which has lagged behind the history of technology as a…”
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Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder by Bunney, B G, Li, J Z, Walsh, D M, Stein, R, Vawter, M P, Cartagena, P, Barchas, J D, Schatzberg, A F, Myers, R M, Watson, S J, Akil, H, Bunney, W E

“…Conventional antidepressants require 2–8 weeks for a full clinical response. In contrast, two rapidly acting antidepressant interventions, low-dose ketamine…”
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HPA axis genetic variation, cortisol and psychosis in major depression by Schatzberg, A F, Keller, J, Tennakoon, L, Lembke, A, Williams, G, Kraemer, F B, Sarginson, J E, Lazzeroni, L C, Murphy, G M

“…Genetic variation underlying hypothalamic pituitary adrenal (HPA) axis overactivity in healthy controls (HCs) and patients with severe forms of major…”
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A Word to the Wise About Intranasal Esketamine by Schatzberg, Alan F

“…Schatzberg discusses the study of Popova et al regarding intranasal esketamine, the putatively more effective enantiomer of ketamine. This pivotal phase 3…”
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HPA axis in psychotic major depression and schizophrenia spectrum disorders: Cortisol, clinical symptomatology, and cognition by Cherian, Kirsten, Schatzberg, Alan F., Keller, Jennifer

“…The Hypothalamic Pituitary Adrenal (HPA) axis has been implicated in the pathophysiology of a variety of mood and cognitive disorders. Neuroendocrine studies…”
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A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders by Sanacora, Gerard, Frye, Mark A, McDonald, William, Mathew, Sanjay J, Turner, Mason S, Schatzberg, Alan F, Summergrad, Paul, Nemeroff, Charles B

“…Several studies now provide evidence of ketamine hydrochloride's ability to produce rapid and robust antidepressant effects in patients with mood and anxiety…”
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An Innovative Approach to Extending the Antidepressant Effects of Intravenous Ketamine in Major Depression by Schatzberg, Alan F.

“…Schatzberg discusses the report by Price et al that automated self-associated training (ASAT) was statistically better than sham treatment in maintaining the…”
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Common Abnormalities and Disorder-Specific Compensation During Implicit Regulation of Emotional Processing in Generalized Anxiety and Major Depressive Disorders by Etkin, Amit, Schatzberg, Alan F.

“…Processing deficits were observed in the ventral anterior cingulate and amygdala of patients with major depression and/or generalized anxiety disorder, but…”
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A Word to the Wise About Ketamine by Schatzberg, Alan F.

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Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism by Williams, Nolan R, Heifets, Boris D, Blasey, Christine, Sudheimer, Keith, Pannu, Jaspreet, Pankow, Heather, Hawkins, Jessica, Birnbaum, Justin, Lyons, David M, Rodriguez, Carolyn I, Schatzberg, Alan F

“…Objective:In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces opioid system activation. The objective of this study was to determine…”
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Some Comments on Psychedelic Research by Schatzberg, Alan F

“…Schatzberg reflects on the effort of the American Psychiatric Association's Council of Research to review studies on psychedelics and psychedelic-assisted…”
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Can Target Engagement Studies Miss Their Targets and Mislead Drug Development? by Schatzberg, Alan F

“…The study by Costi ct aL (1), in this issue of the Journal, reports exciting data that a potassium anion channel modulator, ezogabinc, has a significant effect…”
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Resting-state connectivity biomarkers define neurophysiological subtypes of depression by Drysdale, Andrew T, Grosenick, Logan, Downar, Jonathan, Dunlop, Katharine, Mansouri, Farrokh, Meng, Yue, Fetcho, Robert N, Zebley, Benjamin, Oathes, Desmond J, Etkin, Amit, Schatzberg, Alan F, Sudheimer, Keith, Keller, Jennifer, Mayberg, Helen S, Gunning, Faith M, Alexopoulos, George S, Fox, Michael D, Pascual-Leone, Alvaro, Voss, Henning U, Casey, BJ, Dubin, Marc J, Liston, Conor

“…Using functional MRI in a large multisite sample of more that 1,000 patients, four distinct neurophysiological biotypes of depression are defined. These…”
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Inference of cell type content from human brain transcriptomic datasets illuminates the effects of age, manner of death, dissection, and psychiatric diagnosis by Hagenauer, Megan Hastings, Schulmann, Anton, Li, Jun Z, Vawter, Marquis P, Walsh, David M, Thompson, Robert C, Turner, Cortney A, Bunney, William E, Myers, Richard M, Barchas, Jack D, Schatzberg, Alan F, Watson, Stanley J, Akil, Huda

“…Psychiatric illness is unlikely to arise from pathology occurring uniformly across all cell types in affected brain regions. Despite this, transcriptomic…”
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Neurobiological Signatures of Anxiety and Depression in Resting-State Functional Magnetic Resonance Imaging by Oathes, Desmond J, Patenaude, Brian, Schatzberg, Alan F, Etkin, Amit

“…Abstract Background There is increasing interest in using neurobiological measures to inform psychiatric nosology. It is unclear at the present time whether…”
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