Search Results - "Schatterny, Jolanthe"

Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease by Hey, Joschka, Paulsen, Michelle, Toth, Reka, Weichenhan, Dieter, Butz, Simone, Schatterny, Jolanthe, Liebers, Reinhard, Lutsik, Pavlo, Plass, Christoph, Mall, Marcus A.

“…Lung diseases, such as cystic fibrosis and COPD, are characterized by mucus obstruction and chronic airway inflammation, but their mechanistic link remains…”
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Genetic Deletion of Mmp9 Does Not Reduce Airway Inflammation and Structural Lung Damage in Mice with Cystic Fibrosis-like Lung Disease by Wagner, Claudius, Balázs, Anita, Schatterny, Jolanthe, Zhou-Suckow, Zhe, Duerr, Julia, Schultz, Carsten, Mall, Marcus A

“…Elevated levels of matrix metalloprotease 9 (MMP-9) and neutrophil elastase (NE) are associated with bronchiectasis and lung function decline in patients with…”
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Hypoxic epithelial necrosis triggers neutrophilic inflammation via IL-1 receptor signaling in cystic fibrosis lung disease by Fritzsching, Benedikt, Zhou-Suckow, Zhe, Trojanek, Joanna B, Schubert, Susanne C, Schatterny, Jolanthe, Hirtz, Stephanie, Agrawal, Raman, Muley, Thomas, Kahn, Nicolas, Sticht, Carsten, Gunkel, Nikolas, Welte, Tobias, Randell, Scott H, Länger, Florian, Schnabel, Philipp, Herth, Felix J F, Mall, Marcus A

“…In many organs, hypoxic cell death triggers sterile neutrophilic inflammation via IL-1R signaling. Although hypoxia is common in airways from patients with…”
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CFTR regulates early pathogenesis of chronic obstructive lung disease in βENaC-overexpressing mice by Johannesson, Bjarki, Hirtz, Stephanie, Schatterny, Jolanthe, Schultz, Carsten, Mall, Marcus A

“…Factors determining the onset and severity of chronic obstructive pulmonary disease remain poorly understood. Previous studies demonstrated that airway surface…”
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Microscopic Evidence of Malaria Infection in Visceral Tissue from Medici Family, Italy by Maixner, Frank, Drescher, Dennis, Boccalini, Giulia, Piombino-Mascali, Dario, Janko, Marek, Berens-Riha, Nicole, Kim, Bum Jin, Gamble, Michelle, Schatterny, Jolanthe, Morty, Rory E, Ludwig, Melanie, Krause-Kyora, Ben, Stark, Robert, An, Hyun Joo, Neumann, Jens, Cipollini, Giovanna, Grimm, Rudolf, Kilian, Nicole, Zink, Albert

“…Microscopy of mummified visceral tissue from a Medici family member in Italy identified a potential blood vessel containing erythrocytes. Giemsa staining,…”
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Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema by Trojanek, Joanna B, Cobos-Correa, Amanda, Diemer, Stefanie, Kormann, Michael, Schubert, Susanne C, Zhou-Suckow, Zhe, Agrawal, Raman, Duerr, Julia, Wagner, Claudius J, Schatterny, Jolanthe, Hirtz, Stephanie, Sommerburg, Olaf, Hartl, Dominik, Schultz, Carsten, Mall, Marcus A

“…Whereas cigarette smoking remains the main risk factor for emphysema, recent studies in β-epithelial Na(+) channel-transgenic (βENaC-Tg) mice demonstrated that…”
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Ductal Mucus Obstruction and Reduced Fluid Secretion Are Early Defects in Chronic Pancreatitis by Balázs, Anita, Balla, Zsolt, Kui, Balázs, Maléth, József, Rakonczay, Jr, Zoltán, Duerr, Julia, Zhou-Suckow, Zhe, Schatterny, Jolanthe, Sendler, Matthias, Mayerle, Julia, Kühn, Jens-P, Tiszlavicz, László, Mall, Marcus A, Hegyi, Peter

“…Defective mucus production in the pancreas may be an important factor in the initiation and progression of chronic pancreatitis (CP), therefore we aimed to (i)…”
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Protease FRET Reporters Targeting Neutrophil Extracellular Traps by Guerra, Matteo, Halls, Victoria S, Schatterny, Jolanthe, Hagner, Matthias, Mall, Marcus A, Schultz, Carsten

“…Neutrophil extracellular traps (NETs) consist of DNA released by terminally stimulated neutrophils. They fine-tune inflammation, kill pathogens, activate…”
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Lack of Neutrophil Elastase Reduces Inflammation, Mucus Hypersecretion, and Emphysema, but Not Mucus Obstruction, in Mice with Cystic Fibrosis-like Lung Disease by GEHRIG, Stefanie, DUERR, Julia, MALL, Marcus A, WEITNAUER, Michael, WAGNER, Claudius J, GRAEBER, Simon Y, SCHATTEMY, Jolanthe, HIRTZ, Stephanie, BELAAOUAJ, Abderrazzaq, DALPKE, Alexander H, SCHULTZ, Carsten

“…Recent evidence from clinical studies suggests that neutrophil elastase (NE) released in neutrophilic airway inflammation is a key risk factor for the onset…”
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Chronic rhinosinusitis with nasal polyps is associated with impaired TMEM16A-mediated epithelial chloride secretion by Salomon, Johanna J., Albrecht, Tobias, Graeber, Simon Y., Scheuermann, Heike, Butz, Simone, Schatterny, Jolanthe, Mairbäurl, Heimo, Baumann, Ingo, Mall, Marcus A.

“…Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most common chronic disorders with limited therapeutic options. However, the pathogenesis of…”
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SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation by Anagnostopoulou, Pinelopi, Riederer, Brigitte, Duerr, Julia, Michel, Sven, Binia, Aristea, Agrawal, Raman, Liu, Xuemei, Kalitzki, Katrin, Xiao, Fang, Chen, Mingmin, Schatterny, Jolanthe, Hartmann, Dorothee, Thum, Thomas, Kabesch, Michael, Soleimani, Manoocher, Seidler, Ursula, Mall, Marcus A

“…Asthma is a chronic condition with unknown pathogenesis, and recent evidence suggests that enhanced airway epithelial chloride (Cl-) secretion plays a role in…”
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Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease by Brown, Ryan, Paulsen, Michelle, Schmidt, Simone, Schatterny, Jolanthe, Frank, Angela, Hirtz, Stephanie, Delaney, Rebecca, Doherty, Declan, Hagner, Matthias, Taggart, Cliff, Weldon, Sinéad, Mall, Marcus A

“…Previous studies demonstrated spontaneous type 2 airway inflammation with eosinophilia in juvenile (sodium channel, non-voltage-gated 1, β-subunit)-transgenic…”
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Hypertonic saline is effective in the prevention and treatment of mucus obstruction, but not airway inflammation, in mice with chronic obstructive lung disease by Graeber, Simon Y, Zhou-Suckow, Zhe, Schatterny, Jolanthe, Hirtz, Stephanie, Boucher, Richard C, Mall, Marcus A

“…Recent evidence suggests that inadequate hydration of airway surfaces is a common mechanism in the pathogenesis of airway mucus obstruction. Inhaled hypertonic…”
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Preventive but Not Late Amiloride Therapy Reduces Morbidity and Mortality of Lung Disease in βENaC-overexpressing Mice by ZHE ZHOU, TREIS, Diana, SCHUBERT, Susanne C, HARM, Maria, SCHATTERNY, Jolanthe, HIRTZ, Stephanie, DUERR, Julia, BOUCHER, Richard C, MALL, Marcus A

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Impaired mucus clearance exacerbates allergen-induced type 2 airway inflammation in juvenile mice by Fritzsching, Benedikt, MD, Hagner, Matthias, MS, Dai, Lu, PhD, Christochowitz, Sandra, MS, Agrawal, Raman, PhD, van Bodegom, Charlotte, Schmidt, Simone, Schatterny, Jolanthe, Hirtz, Stephanie, MS, Brown, Ryan, PhD, Goritzka, Michelle, PhD, Duerr, Julia, PhD, Zhou-Suckow, Zhe, PhD, Mall, Marcus A., MD

“…Background Type 2 airway inflammation plays a central role in the pathogenesis of allergen-induced asthma, but the underlying mechanisms remain poorly…”
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CFTR Regulates Early Pathogenesis of Chronic Obstructive Lung Disease in [beta]ENaC-Overexpressing Mice by Johannesson, Bjarki, Hirtz, Stephanie, Schatterny, Jolanthe, Schultz, Carsten, Mall, Marcus A

“…Background Factors determining the onset and severity of chronic obstructive pulmonary disease remain poorly understood. Previous studies demonstrated that…”
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Imbalance of mucus homeostasis in chronic pancreatitis by Balázs, Anita, Duerr, Julia, Zhou-Shuckow, Zhe, Schatterny, Jolanthe, Tiszlavicz, Laszlo, Nemeth, Istvan Balazs, Kui, Balazs, Rakonczay, Zoltan, Mall, Marcus, Hegyi, Peter

“…Introduction: Qualitative and/or quantitative changes of mucus in the pancreas are important factors both in the initiation and progression of chronic…”
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Imbalance of mucus homeostasis in chronic pancreatitis by Balázs, Anita, Duerr, Julia, Zhou-Suckow, Zhe, Schatterny, Jolanthe, Tiszlavicz, László, Németh, István B, Kui, Balázs, Balla, Zsolt, Rakonczay, Zoltán, Sendler, Matthias, Mayerle, Julia, Kühn, Jens-Peter, Mall, Marcus A, Hegyi, Péter

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Mucus secretion of pancreatic ductal epithelium increases in chronic pancreatitis by Balázs, Anita, Julia, Duerr, Zhou-Suckow, Zhe, Schatterny, Jolanthe, Németh, István Balázs, László, Tiszlavicz, Rakonczay, Zoltán, Mall, Marcus A, Hegyi, Péter

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SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation by Anagnostopoulou, Pinelopi, Riederer, Brigitte, Duerr, Julia, Miche1, Sven, Binia, Aristea, Agrawal, Raman, Liu, Xuemei, Kalitzki, Katrin, Xiao, Fang, Chen, Mingmin, Schatterny, Jolanthe, Hartmann, Dorothee, Thum, Thomas, Kabesch, Michael, Soleimani, Manoocher, Seidler, Ursula, Mall, Marcus A

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