Search Results - "Schartman, Richard R."

Utilization of In Vitro, In Vivo and In Silico Tools to Evaluate the pH-Dependent Absorption of a BCS Class II Compound and Identify a pH-Effect Mitigating Strategy by Gesenberg, Christoph, Mathias, Neil R., Xu, Yan, Crison, John, Savant, Ishani, Saari, Amy, Good, David J., Hemenway, Jeffrey N., Narang, Ajit S., Schartman, Richard R., Zheng, Naiyu, Buzescu, Adela, Patel, Jatin

“…Purpose To describe a stepwise approach to evaluate the pH effect for a weakly basic drug by in vitro , in vivo and in silico techniques and identify a viable…”
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On the thermodynamics of cocrystal formation by Schartman, Richard R.

“…The thermodynamics underpinning cocrystal formation are derived. The results provide the pharmaceutical scientist with the foundation to experimentally assess…”
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Surfactant choice and the physical stability of nanosuspensions as a function of pH by Donoso, Maria D., Haskell, Roy J., Schartman, Richard R.

“…Nanosuspensions of the example compounds ketoconazole and itraconazole were shown to aggregate upon reducing the pH to levels comparable to that known to exist…”
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In Vivo Dissolution Rates: An Error Analysis by Schartman, Richard R., Carstensen, Jens T.

“…Abstract The uncertainty associated with the determination of in vivo dissolution rates was determined by Monte Carlo simulation. Error was imposed upon sets…”
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