Search Results - "Scharre, Douglas W."

Explainable machine learning aggregates polygenic risk scores and electronic health records for Alzheimer’s disease prediction by Gao, Xiaoyi Raymond, Chiariglione, Marion, Qin, Ke, Nuytemans, Karen, Scharre, Douglas W., Li, Yi-Ju, Martin, Eden R.

“…Alzheimer’s disease (AD) is the most common late-onset neurodegenerative disorder. Identifying individuals at increased risk of developing AD is important for…”
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Deep Brain Stimulation of Frontal Lobe Networks to Treat Alzheimer's Disease by Scharre, Douglas W, Weichart, Emily, Nielson, Dylan, Zhang, Jun, Agrawal, Punit, Sederberg, Per B, Knopp, Michael V, Rezai, Ali R

“…The study objective was to evaluate the safety and efficacy of deep brain stimulation (DBS) at the ventral capsule/ventral striatum (VC/VS) region to…”
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Motor Performance Differentiates Individuals with Lewy Body Dementia, Parkinson’s and Alzheimer’s Disease by Fritz, Nora E., PhD, PT, DPT, NCS, Kegelmeyer, Deborah A., PT, MS, DPT, GCS, Kloos, Anne D., PT, PhD, NCS, Linder, Shannon, CNP, Park, Ariane, MD, MPH, Kataki, Maria, MD, PhD, Adeli, Anahita, MD, Agrawal, Punit, DO, Scharre, Douglas W., MD, Kostyk, Sandra K., MD PhD

“…Highlights • When matched for disease severity, motor measures distinguish LBD from PD and AD. • The Tinetti balance scale differentiates individuals with DLB…”
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Self-Administered Gerocognitive Examination: longitudinal cohort testing for the early detection of dementia conversion by Scharre, Douglas W, Chang, Shu Ing, Nagaraja, Haikady N, Wheeler, Natalie C, Kataki, Maria

“…Significant cognitive changes as individuals' age are not being identified in a timely manner, delaying diagnosis and treatments. Use of brief, multi-domain,…”
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Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease by Chen, Shuo, Chang, Yuzhou, Li, Liangping, Acosta, Diana, Li, Yang, Guo, Qi, Wang, Cankun, Turkes, Emir, Morrison, Cody, Julian, Dominic, Hester, Mark E, Scharre, Douglas W, Santiskulvong, Chintda, Song, Sarah XueYing, Plummer, Jasmine T, Serrano, Geidy E, Beach, Thomas G, Duff, Karen E, Ma, Qin, Fu, Hongjun

“…Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer's disease (AD), but little is known about the molecular mechanisms underlying…”
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Correction to: Self-Administered Gerocognitive Examination: longitudinal cohort testing for the early detection of dementia conversion by Scharre, Douglas W, Chang, Shu Ing, Nagaraja, Haikady N, Wheeler, Natalie C, Kataki, Maria

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Blood genome-wide transcriptional profiles reflect broad molecular impairments and strong blood-brain links in Alzheimer's disease by Naughton, Bartholomew J, Duncan, F Jason, Murrey, Darren A, Meadows, Aaron S, Newsom, David E, Stoicea, Nicoleta, White, Peter, Scharre, Douglas W, Mccarty, Douglas M, Fu, Haiyan

“…To date, little is known regarding the etiology and disease mechanisms of Alzheimer's disease (AD). There is a general urgency for novel approaches to advance…”
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Digitally translated Self-Administered Gerocognitive Examination (eSAGE): relationship with its validated paper version, neuropsychological evaluations, and clinical assessments by Scharre, Douglas W, Chang, Shu Ing, Nagaraja, Haikady N, Vrettos, Nicole E, Bornstein, Robert A

“…The original paper Self-Administered Gerocognitive Examination (SAGE) is a valid and reliable cognitive assessment tool used to identify individuals with mild…”
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Self-administered gerocognitive examination (SAGE) aids early detection of cognitive impairment at primary care provider visits by Scharre, Douglas W, Vrettos, Nicole E, Nagaraja, Haikady N, Wexler, Randell K, Clark, Aaron D, Nguyen, Christopher M

“…Current estimates indicate that up to 50-75% of dementia cases are undiagnosed at an early stage when treatments are most effective. Conducting robust accurate…”
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Potential Neuroprotective Effects of Dietary Omega-3 Fatty Acids on Stress in Alzheimer's Disease by Hartnett, Kaitlyn B, Ferguson, Bradley J, Hecht, Patrick M, Schuster, Luke E, Shenker, Joel I, Mehr, David R, Fritsche, Kevin L, Belury, Martha A, Scharre, Douglas W, Horwitz, Adam J, Kille, Briana M, Sutton, Briann E, Tatum, Paul E, Greenlief, C Michael, Beversdorf, David Q

“…A large number of individual potentially modifiable factors are associated with risk for Alzheimer's disease (AD). However, less is known about the…”
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Discriminating Memory Disordered Patients From Controls Using Diffusion Model Parameters From Recognition Memory by Ratcliff, Roger, Scharre, Douglas W., McKoon, Gail

“…One hundred and five memory disordered (MD) patients and 57 controls were tested on item recognition memory and lexical decision tasks, and diffusion model…”
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Race-Related Differences Between and Within Sex to Experimental Thermal Pain in Middle and Older Adulthood: An Exploratory Pilot Analysis by Moss, Karen O, Wright, Kathy D, Tan, Alai, Rose, Karen M, Scharre, Douglas W, Gure, Tanya R, Cowan, Ronald L, Failla, Michelle D, Monroe, Todd B

“…This brief report details a pilot analysis conducted to explore racial differences in pain sensitivity and unpleasantness between cognitively healthy Black and…”
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Treating the most vulnerable: A discursive review of experimental pain in Alzheimer’s disease by Iversen, Wm. Larkin, Cowan, Ronald L., Atalla, Sebastian, Englehart, Sydney S., Gure, Tanya R., Moss, Karen O., Ryan, Claire M., Scharre, Douglas W., Wright, Kathy D., Monroe, Todd B.

“…Aim The purpose of this manuscript is to summarize research on how experimental pain is experienced by adults with Alzheimer's disease (AD) and to translate…”
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The Dilemma of the Clinical Utility of Alzheimer Biomarker Evaluation in Everyday Clinical Practice: My Favorite PETs by Beversdorf, David Q., Scharre, Douglas W.

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Detection of Cognitive Impairment From eSAGE Metadata Using Machine Learning by Kawakami, Ryoma, Wright, Kathy D, Scharre, Douglas W, Ning, Xia

“…Using the metadata collected in the digital version of the Self-Administered Gerocognitive Examination (eSAGE), we aim to improve the prediction of mild…”
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Defining and Diagnosing Involuntary Emotional Expression Disorder by Cummings, Jeffrey L., Arciniegas, David B., Brooks, Benjamin R., Herndon, Robert M., Lauterbach, Edward C., Pioro, Erik P., Robinson, Robert G., Scharre, Douglas W., Schiffer, Randolph B., Weintraub, Daniel

“…Uncontrollable episodes of emotional expression occur in a variety of neurological conditions. This emotional disinhibition syndrome is characterized by…”
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Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial by Cummings, Jeffrey L, Lyketsos, Constantine G, Peskind, Elaine R, Porsteinsson, Anton P, Mintzer, Jacobo E, Scharre, Douglas W, De La Gandara, Jose E, Agronin, Marc, Davis, Charles S, Nguyen, Uyen, Shin, Paul, Tariot, Pierre N, Siffert, João

“…IMPORTANCE: Agitation is common among patients with Alzheimer disease; safe, effective treatments are lacking. OBJECTIVE: To assess the efficacy, safety, and…”
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Gene expression profiling of brain samples from patients with Lewy body dementia by Pietrzak, Maciej, Papp, Audrey, Curtis, Amanda, Handelman, Samuel K., Kataki, Maria, Scharre, Douglas W., Rempala, Grzegorz, Sadee, Wolfgang

“…Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative disorder in the elderly. The development and progression of DLB remain unclear. In…”
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Mindfulness in Motion and Dietary Approaches to Stop Hypertension (DASH) in Hypertensive African Americans by Wright, Kathy D., Klatt, Maryanna D., Adams, Ingrid Richards, Nguyen, Christopher M., Mion, Lorraine C., Tan, Alai, Monroe, Todd B., Rose, Karen M., Scharre, Douglas W.

“…Objectives Hypertension increases the risk of developing Alzheimer's disease or related dementias. This pilot study's purpose was to examine the feasibility…”
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Wolframin is a novel regulator of tau pathology and neurodegeneration by Chen, Shuo, Acosta, Diana, Li, Liangping, Liang, Jiawen, Chang, Yuzhou, Wang, Cankun, Fitzgerald, Julie, Morrison, Cody, Goulbourne, Chris N., Nakano, Yoshi, Villegas, Nancy C. Hernandez, Venkataraman, Lalitha, Brown, Cris, Serrano, Geidy E., Bell, Erica, Wemlinger, Trina, Wu, Min, Kokiko-Cochran, Olga N., Popovich, Phillip, Flowers, Xena E., Honig, Lawrence S., Vonsattel, Jean Paul, Scharre, Douglas W., Beach, Thomas G., Ma, Qin, Kuret, Jeff, Kõks, Sulev, Urano, Fumihiko, Duff, Karen E., Fu, Hongjun

“…Selective neuronal vulnerability to protein aggregation is found in many neurodegenerative diseases including Alzheimer’s disease (AD). Understanding the…”
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