Search Results - "Scharnagl, C."

Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics by Langosch, D., Scharnagl, C., Steiner, H., Lemberg, M.K.

“…•How intramembrane proteases select their substrates is currently unknown.•Helix-destabilizing amino acids within transmembrane helices often facilitate…”
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Molecular Basis for pH Sensitivity and Proton Transfer in Green Fluorescent Protein: Protonation and Conformational Substates from Electrostatic Calculations by Scharnagl, C., Raupp-Kossmann, R., Fischer, S.F.

“…We performed a theoretical study to elucidate the coupling between protonation states and orientation of protein dipoles and buried water molecules in green…”
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pKa shifts for protonation-dependent degrees of freedom by RAUPP-KOSSMANN, R. A, SCHARNAGL, C

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Symmetry breakage in the electronic structure of bacterial reaction centers by Scherer, P.O.J., Scharnagl, C., Fischer, Sighart F.

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Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage by Götz, Alexander, Mylonas, Nadine, Högel, Philipp, Silber, Mara, Heinel, Hannes, Menig, Simon, Vogel, Alexander, Feyrer, Hannes, Huster, Daniel, Luy, Burkhard, Langosch, Dieter, Scharnagl, Christina, Muhle-Goll, Claudia, Kamp, Frits, Steiner, Harald

“…Intramembrane cleavage of the β-amyloid precursor protein C99 substrate by γ-secretase is implicated in Alzheimer’s disease pathogenesis. Biophysical data have…”
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Stability of proteins: Temperature, pressure and the role of the solvent by Scharnagl, Christina, Reif, Maria, Friedrich, Josef

“…We focus on the various aspects of the physics related to the stability of proteins. We review the pure thermodynamic aspects of the response of a protein to…”
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Experimental discovery of T-cell epitopes: combining the best of classical and contemporary approaches by Scharnagl, Nicole C, Klade, Christoph S

“…T cells specifically recognize antigens as peptide epitope-MHC complexes on the surface of target cells. The inherent complexities of antigen processing and…”
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Solution pK a Values of the Green Fluorescent Protein Chromophore from Hybrid Quantum-Classical Calculations by Scharnagl, Christina, Raupp-Kossmann, Robert A

“…We present a theoretical study of the four aqueous microscopic dissociation constants relating the relevant protonation forms (cation, neutral, anion,…”
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Local Compressibilities of Proteins: Comparison of Optical Experiments and Simulations for Horse Heart Cytochrome- c by Scharnagl, Christina, Reif, Maria, Friedrich, Josef

“…Spectroscopy with probe molecules yields local information on the environment of the probe. In this article we compare local compressibilities of cytochrome- c…”
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Local compressibilities in insulin as determined from pressure tuning hole burning experiments and MD simulations by Schnell, Christoph, Reif, Maria, Scharnagl, Christina, Friedrich, Josef

“…We present a hole burning study on insulin in a glycerol-water solvent by using the intrinsic amino acid tyrosine as a photochemical probe. The focus of the…”
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Hole burning spectroscopy of ribonuclease A by Schnell, Christoph, Scharnagl, Christina, Friedrich, Josef

“…We present pressure tuning hole burning experiments with the enzyme ribonuclease A using the UV-absorbing amino acid tyrosine as a probe. We show that, at 2 K,…”
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p Ka shifts for protonation-dependent degrees of freedom by Raupp-Kossmann, R.A., Scharnagl, C.

“…Conventional p K a calculations neglect the entropic contributions to the change in free energy for transferring the model compound from the solvent into the…”
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Conformational flexibility of arginine-82 as source for the heterogeneous and pH-dependent kinetics of the primary proton transfer step in the bacteriorhodopsin photocycle: An electrostatic model by Scharnagl, Christina, Fischer, Sighart F.

“…We use equilibrium thermodynamic concepts to relate protein conformational and protonation substates and their pH-dependent population to kinetic schemes for…”
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Electrostatic and Conformational Effects on the Proton Translocation Steps in Bacteriorhodopsin: Analysis of Multiple M Structures by Scharnagl, Christina, Hettenkofer, Johannes, Fischer, Sighart F

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A force field calculation for trans-stillbene ion radicals by SCHNEIDER, S, SCHARNAGL, C, BUG, R, BARANOVIC, G, MEIC, Z

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Circular dichroism of chromopeptides from phycocyanin by Scharnagl, C, Kost-Reyes, E, Schneider, S, Kost, H.P, Scheer, H

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Circular dichroism of chromopeptides from phycocyanin by SCHARNAGL, C, KÖST-REYES, E, SCHNEIDER, S, KÖST, H.-P, SCHEER, H

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