Search Results - "Scharnagl, C."
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Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01-06-2015)“…•How intramembrane proteases select their substrates is currently unknown.•Helix-destabilizing amino acids within transmembrane helices often facilitate…”
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Molecular Basis for pH Sensitivity and Proton Transfer in Green Fluorescent Protein: Protonation and Conformational Substates from Electrostatic Calculations
Published in Biophysical journal (01-10-1999)“…We performed a theoretical study to elucidate the coupling between protonation states and orientation of protein dipoles and buried water molecules in green…”
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pKa shifts for protonation-dependent degrees of freedom
Published in Chemical physics letters (01-03-2001)Get full text
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Symmetry breakage in the electronic structure of bacterial reaction centers
Published in Chemical physics (15-08-1995)Get full text
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Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage
Published in Biophysical journal (04-06-2019)“…Intramembrane cleavage of the β-amyloid precursor protein C99 substrate by γ-secretase is implicated in Alzheimer’s disease pathogenesis. Biophysical data have…”
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Stability of proteins: Temperature, pressure and the role of the solvent
Published in Biochimica et biophysica acta (01-06-2005)“…We focus on the various aspects of the physics related to the stability of proteins. We review the pure thermodynamic aspects of the response of a protein to…”
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Experimental discovery of T-cell epitopes: combining the best of classical and contemporary approaches
Published in Expert review of vaccines (01-08-2007)“…T cells specifically recognize antigens as peptide epitope-MHC complexes on the surface of target cells. The inherent complexities of antigen processing and…”
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Solution pK a Values of the Green Fluorescent Protein Chromophore from Hybrid Quantum-Classical Calculations
Published in The journal of physical chemistry. B (08-01-2004)“…We present a theoretical study of the four aqueous microscopic dissociation constants relating the relevant protonation forms (cation, neutral, anion,…”
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Local Compressibilities of Proteins: Comparison of Optical Experiments and Simulations for Horse Heart Cytochrome- c
Published in Biophysical journal (01-07-2005)“…Spectroscopy with probe molecules yields local information on the environment of the probe. In this article we compare local compressibilities of cytochrome- c…”
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Local compressibilities in insulin as determined from pressure tuning hole burning experiments and MD simulations
Published in Physical chemistry chemical physics : PCCP (21-05-2005)“…We present a hole burning study on insulin in a glycerol-water solvent by using the intrinsic amino acid tyrosine as a photochemical probe. The focus of the…”
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Hole burning spectroscopy of ribonuclease A
Published in Physical chemistry chemical physics : PCCP (01-01-2006)“…We present pressure tuning hole burning experiments with the enzyme ribonuclease A using the UV-absorbing amino acid tyrosine as a probe. We show that, at 2 K,…”
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p Ka shifts for protonation-dependent degrees of freedom
Published in Chemical physics letters (09-03-2001)“…Conventional p K a calculations neglect the entropic contributions to the change in free energy for transferring the model compound from the solvent into the…”
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Conformational flexibility of arginine-82 as source for the heterogeneous and pH-dependent kinetics of the primary proton transfer step in the bacteriorhodopsin photocycle: An electrostatic model
Published in Chemical physics (15-11-1996)“…We use equilibrium thermodynamic concepts to relate protein conformational and protonation substates and their pH-dependent population to kinetic schemes for…”
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A force field calculation for trans-stillbene ion radicals
Published in Journal of physical chemistry (1952) (1992)Get full text
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Circular dichroism of chromopeptides from phycocyanin
Published in Zeitschrift für Naturforschung. Section C, Biosciences (1983)Get full text
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Circular dichroism of chromopeptides from phycocyanin
Published in Zeitschrift für Naturforschung. Section C, Biosciences (1983)Get full text
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