Search Results - "Schargel, Richard D."

Structures of the holo CRISPR RNA-guided transposon integration complex by Park, Jung-Un, Tsai, Amy Wei-Lun, Rizo, Alexandrea N., Truong, Vinh H., Wellner, Tristan X., Schargel, Richard D., Kellogg, Elizabeth H.

“…CRISPR-associated transposons (CAST) are programmable mobile genetic elements that insert large DNA cargos using an RNA-guided mechanism 1 – 3 . CAST elements…”
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High-level carbapenem tolerance requires antibiotic-induced outer membrane modifications by Murtha, Andrew N, Kazi, Misha I, Schargel, Richard D, Cross, Trevor, Fihn, Conrad, Cattoir, Vincent, Carlson, Erin E, Boll, Joseph M, Dörr, Tobias

“…Antibiotic tolerance is an understudied potential contributor to antibiotic treatment failure and the emergence of multidrug-resistant bacteria. The molecular…”
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Peptidoglycan Recycling Promotes Outer Membrane Integrity and Carbapenem Tolerance in Acinetobacter baumannii by Islam, Nowrosh, Kazi, Misha I, Kang, Katie N, Biboy, Jacob, Gray, Joe, Ahmed, Feroz, Schargel, Richard D, Boutte, Cara C, Dörr, Tobias, Vollmer, Waldemar, Boll, Joseph M

“…β-Lactam antibiotics exploit the essentiality of the bacterial cell envelope by perturbing the peptidoglycan layer, typically resulting in rapid lysis and…”
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Structure of Fanzor2 reveals insights into the evolution of the TnpB superfamily by Schargel, Richard D, Qayyum, M Zuhaib, Tanwar, Ajay Singh, Kalathur, Ravi C, Kellogg, Elizabeth H

“…RNA-guided endonucleases, once thought to be exclusive to prokaryotes, have been recently identified in eukaryotes and are called Fanzors. They are classified…”
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Discovery and characterization of New Delhi metallo-β-lactamase-1 inhibitor peptides that potentiate meropenem-dependent killing of carbapenemase-producing Enterobacteriaceae by Kazi, Misha I, Perry, Blair W, Card, Daren C, Schargel, Richard D, Ali, Hana B, Obuekwe, Victor C, Sapkota, Madhab, Kang, Katie N, Pellegrino, Mark W, Greenberg, David E, Castoe, Todd A, Boll, Joseph M

“…Abstract Objectives Metallo-β-lactamases (MBLs) are an emerging class of antimicrobial resistance enzymes that degrade β-lactam antibiotics, including…”
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Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing by Kazi, Misha I, Schargel, Richard D, Boll, Joseph M

“…Transposon sequencing (Tn-seq) is a powerful method that combines transposon mutagenesis and massive parallel sequencing to identify genes and pathways that…”
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