Search Results - "Schapoval, Elfrides E. S."

Gemifloxacin mesylate (GFM) stability evaluation applying a validated bioassay method and in vitro cytotoxic study by Paim, Clésio S., Führ, Fernanda, Barth, Aline B., Gonçalves, Carlos E.I., Nardi, Nance, Steppe, Martin, Schapoval, Elfrides E.S.

“…The validation of a microbiological assay applying the cylinder–plate method to determine the quinolone gemifloxacin mesylate (GFM) content is described. Using…”
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Stability and degradation products of imipenem applying high‐resolution mass spectrometry: An analytical study focused on solutions for infusion by Souza Barbosa, Fábio, Capra Pezzi, Leonardo, Tsao, Marisa, Franco de Oliveira, Tiago, Manoela Dias Macedo, Sandra, E.S. Schapoval, Elfrides, S.L. Mendez, Andreas

“…Carbapenems show recognized instability in aqueous solutions; therefore some care must be taken in their handling and preparation and their use in the hospital…”
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Bioassay-guided isolation of antimicrobial benzopyrans and phloroglucinol derivatives from Hypericum species by Dall'Agnol, R, Ferraz, A, Bernardi, A.P, Albring, D, Nor, C, Schapoval, E.E.S, Poser, G.L. von

“…Recently the crude methanol extracts of six Hypericum species were analysed against a panel of microorganisms and it was found that H. caprifoliatum Cham. &…”
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Biological safety studies of gemifloxacin mesylate and related substances by Paim, Clésio S, Nogueira, Daniele R, Mitjans, Montserrat, Ramos Lopez, David, de Lapuente Perez, Joaquin, Steppe, Martin, Schapoval, Elfrides E S, Vinardell, María Pilar

“…The aim of this study was to evaluate the cytotoxic, phototoxic, genotoxic and photogenotoxic potential of gemifloxacin mesylate (GFM), its main synthetic…”
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Dissolution test for citalopram in tablets and comparison of in vitro dissolution profiles by Menegola, Júlia, Steppe, Martin, Schapoval, Elfrides E.S.

“…A dissolution test for tablets containing 20 mg of citalopram was developed and validated using a reverse-phase liquid chromatographic method and this…”
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HPLC-DAD for the determination of three different classes of antifungals: method characterization, statistical approach, and application to a permeation study by Miron, Diogo, Lange, Alini, Zimmer, Aline R., Mayorga, Paulo, Schapoval, Elfrides E. S.

“…ABSTRACT This study describes and characterizes methods for high‐performance liquid chromatography diode array detection (HPLC‐DAD) analysis of formulations…”
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Structural elucidation of rabeprazole sodium photodegradation products by Garcia, Cássia V., Nudelman, Norma S., Steppe, Martin, Schapoval, Elfrides E.S.

“…Rabeprazole sodium is a proton pump inhibitor, used in acid-related disorders, like peptic ulcers and gastroesophageal reflux. It is known to be an acid-labile…”
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Development and validation of a dissolution test for rabeprazole sodium in coated tablets by Garcia, Cassia V., Paim, Clesio S., Steppe, Martin, Schapoval, Elfrides E.S.

“…The aim of this work is to develop and validate a dissolution test for rabeprazole sodium coated tablets using a reverse-phase liquid chromatographic method…”
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Characterization of the antibiotic doripenem using physicochemical methods: chromatography, spectrophotometry, spectroscopy and thermal analysis by Mendez, Andreas S. L, Mantovani, Luciano, Barbosa, Fábio, Sayago, Carla T. M, Garcia, Cássia V, Paula, Fávero R, Silva, Fabiana E. B. da, Denardin, Elton L. G, Schapoval, Elfrides E. S

“…Doripenem was characterized through physicochemical and spectroscopic techniques, as well as thermal analysis. TLC (Rf = 0.62) and HPLC (rt = 7.4 min) were…”
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LC method for telithromycin in tablets: A stability-indicating assay by Vaucher, Lauren C., Paim, Clésio S., Lange, Alini D., Schapoval, Elfrides E.S.

“…A liquid chromatographic (LC) method for the quantitative determination of telithromycin, the first member of the ketolides, which is a new class of…”
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Stress Degradation Studies and Kinetic Determinations of Duloxetine Enteric-Coated Pellets by HPLC by GOMES, Patricia, WINGERT, Nathalie R, PAIM, Clésio S, SCHAPOVAL, Elfrides E. S, STEPPE, Martin

“…A stability-indicating HPLC assay method was developed for the quantitative determination of duloxetine (DLX) in a pharmaceutical dosage form in the presence…”
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Development and Validation of Column High-Performance Liquid Chromatographic and Ultraviolet Spectrophotometric Methods for Citalopram in Tablets by MENEGOLA, Julia, STEPPE, Martin, SCHAPOVAL, Elfrides E. S

“…Column high-performance liquid chromatographic (LC) and UV spectrophotometric methods for the quantitative determination of citalopram, a potent and selective…”
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Application of Quality by Design to optimize a stability-indicating LC method for the determination of ticagrelor and its impurities by Wingert, Nathalie R., Ellwanger, Jéssica B., Bueno, Lívia M., Gobetti, Caren, Garcia, Cássia V., Steppe, Martin, Schapoval, Elfrides E.S.

“…Simultaneous analysis of drug compounds and their impurities of degradation and synthesis became constant in the modern pharmaceutical analysis. Likewise,…”
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Stability and degradation kinetics of meropenem in powder for injection and reconstituted sample by Mendez, Andreas S.L., Dalomo, Jean, Steppe, Martin, Schapoval, Elfrides E.S.

“…The stability of broad-spectrum antibiotic meropenem was studied in order to investigate the kinetics of degradation of this drug in powder for injection and…”
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Anti-inflammatory effect of rosmarinic acid isolated from Blechnum brasiliense in adult zebrafish brain by Fasolo, Juliana M.M.A., Vizuete, Adriana Fernanda K., Rico, Eduardo P., Rambo, Renata B.S., Toson, Natally S.B., Santos, Emerson, de Oliveira, Diogo L., Gonçalves, Carlos A.S., Schapoval, Elfrides E.S., Heriques, Amélia T.

“…Neuroinflammation has been associated to neurodegenerative disease development, with evidence suggesting that high levels of proinflammatory cytokines promote…”
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New High-Performance Liquid Chromatographic Method for Determination of Clopidogrel in Coated Tablets by SIPPEL, Juliana, SFAIR, Leticial, SCHAPOVAL, Elfrides E. S, STEPPE, Martin

“…A new high-performance liquid chromatographic method was developed and validated for clopidogrel determination in pharmaceutical formulations. The system…”
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Analytical Quality by Design Approach for a Stability-Indicating Method to Determine Apixaban and Its Related Impurities by Ellwanger, Jéssica B., Wingert, Nathalie Ribeiro, Volpato, Nadia Maria, Garcia, Cássia Virginia, Schapoval, Elfrides E. S., Steppe, Martin

“…Quality by Design (QbD) is a systematic approach that takes predefined objectives and emphasizes process understanding and control. Analytical QbD (AQbD) is…”
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Stability in clinical use and stress testing of meropenem antibiotic by direct infusion ESI-Q-TOF: Quantitative method and identification of degradation products by de Souza Barbosa, Fábio, Capra Pezzi, Leonardo, Tsao, Marisa, Dias Macedo, Sandra Manoela, de Oliveira, Tiago Franco, Schapoval, Elfrides E.S., Mendez, Andreas S.L.

“…[Display omitted] •A simple direct infusion method by ESI-Q-TOF for quantification of meropenem in infusion fluids was validated.•Stability after…”
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Development and validation of liquid chromatographic and ultraviolet derivative spectrophotometric methods for determination of epinastine hydrochloride in coated tablets by DAL MOLIM GHISLENI, Daniela, STEPPE, Martin, SCHAPOVAL, Elfrides E. S

“…High-performance liquid chromatographic (LC) and ultraviolet derivative spectrophotometric (UVD) methods were developed and validated for the quantitative…”
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Microbiological assay for the determination of telithromycin in tablets by VAUCHER, Lauren C, BREIER, Ana R, SCHAPOVAL, Elfrides E. S

“…This study describes the development and validation of a microbiological assay, applying the cylinder-plate method, for the determination of the antibiotic…”
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