Search Results - "Schamus, Sandy"

ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1 by Moiseeva, Tatiana, Hood, Brian, Schamus, Sandy, O’Connor, Mark J., Conrads, Thomas P., Bakkenist, Christopher J.

“…ATR kinase activity slows replication forks and prevents origin firing in damaged cells. Here we describe proteomic analyses that identified mechanisms through…”
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HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β by Fang, Qingming, Inanc, Burcu, Schamus, Sandy, Wang, Xiao-hong, Wei, Leizhen, Brown, Ashley R., Svilar, David, Sugrue, Kelsey F., Goellner, Eva M., Zeng, Xuemei, Yates, Nathan A., Lan, Li, Vens, Conchita, Sobol, Robert W.

“…Cellular DNA repair processes are crucial to maintain genome stability and integrity. In DNA base excision repair, a tight heterodimer complex formed by DNA…”
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Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation by Vendetti, Frank P., Leibowitz, Brian J., Barnes, Jennifer, Schamus, Sandy, Kiesel, Brian F., Abberbock, Shira, Conrads, Thomas, Clump, David Andy, Cadogan, Elaine, O’Connor, Mark J., Yu, Jian, Beumer, Jan H., Bakkenist, Christopher J.

“…We show that ATM kinase inhibition using AZ31 prior to 9 or 9.25 Gy total body irradiation (TBI) reduced median time to moribund in mice to 8 days. ATR kinase…”
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HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase [beta] by Fang, Qingming, Inanc, Burcu, Schamus, Sandy, Wang, Xiao-hong, Wei, Leizhen, Brown, Ashley R, Svilar, David, Sugrue, Kelsey F, Goellner, Eva M, Zeng, Xuemei, Yates, Nathan A, Lan, Li, Vens, Conchita, Sobol, Robert W

“…Cellular DNA repair processes are crucial to maintain genome stability and integrity. In DNA base excision repair, a tight heterodimer complex formed by DNA…”
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Abstract 2379: 96-Well CometChip validation for simultaneous treatment and measurement of DNA damage in a single platform by Woodgate, Sandra R., Whittaker, Clare, George, Jay, Sobol, Robert W., Schamus-Haynes, Sandy, Engelward, Bevin P., Ge, Jing

“…The 96-Well CometChip System is a high-throughput platform to simultaneously treat and measure DNA damage induced by different treatments, or among different…”
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Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage by Jelezcova, Elena, Trivedi, Ram N, Wang, Xiao-Hong, Tang, Jiang-Bo, Brown, Ashley R, Goellner, Eva M, Schamus, Sandy, Fornsaglio, Jamie L, Sobol, Robert W

“…Alkylating agents induce cell death in wild-type (WT) mouse embryonic fibroblasts (MEFs) by multiple mechanisms, including apoptosis, autophagy and necrosis…”
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