Nutritional Formula Enhanced Immune Function and Reduced Days of Symptoms of Upper Respiratory Tract Infection in Seniors

Objectives: To assess whether an experimental nutritional formula, given as a supplement, would reduce days of symptoms of upper respiratory tract infection (URTI) and affect antibody and lymphocyte proliferative responses to influenza vaccine. Design: A prospective, randomized, double‐blind, contro...

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Published in:	Journal of the American Geriatrics Society (JAGS) Vol. 52; no. 1; pp. 3 - 12
Main Authors:	Langkamp-henken PhD, Bobbi, Bender MD, Bradley S., Gardner PhD, Elizabeth M., Herrlinger-garcia BS, Kelli A., Kelley PhD, Michael J., Murasko PhD, Donna M., Schaller PhD, Joseph P., Stechmiller PhD, Joyce K., Thomas MS, Debra J., Wood PhD, Steven M.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Inc 01-01-2004 Blackwell Wiley Subscription Services, Inc
Subjects:	Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibody Formation - physiology antibody response Biological and medical sciences Chi-Square Distribution Dietary Supplements Double blind randomized controlled trials Double-Blind Method Duration Elderly people Emergency and intensive care: digestive diseases. Bioartificial liver Female Florida Humans Immune response Immune system immunity infection influenza Influenza Vaccines - immunology Intensive care medicine Lymphocyte Count Male Medical sciences Nutrition Nutritional Status Older people Prospective Studies Respiratory system Respiratory tract infection Respiratory Tract Infections - immunology seniors Statistics, Nonparametric Supplements Symptoms USA Vitamin E - blood Florida Human Lung disease Pneumonia Immune response Upper respiratory tract Respiratory disease Cellular immunity Feeding Infection Symptomatology Bacteriosis Supplementation Day Elderly
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Summary:	Objectives: To assess whether an experimental nutritional formula, given as a supplement, would reduce days of symptoms of upper respiratory tract infection (URTI) and affect antibody and lymphocyte proliferative responses to influenza vaccine. Design: A prospective, randomized, double‐blind, controlled trial was conducted between October 1999 and April 2000. Setting: Assisted‐ and independent‐living facilities in North Central Florida. Participants: Sixty‐six individuals, aged 65 and older. Intervention: Subjects received 8 oz/d of an experimental formula containing antioxidants, zinc, selenium, fermentable oligosaccharides, and structured triacylglycerol or an isoenergetic, isonitrogenous control formula for 183 days. Measurements: Subjects recorded daily symptoms of URTI. Antibody titers and lymphocyte proliferation to three influenza vaccine components were measured on Days 57 and 183. Results: Eighteen subjects in the control group and 16 subjects in the experimental group consumed an average of 7 ounces of formula daily and completed the 183‐day study. Median days of symptoms of URTI were 3 (range 0–69, total days=156) and 0 (range 0–49, total days=78) for the control and experimental groups, respectively (P= .049). On Day 57, seven of 17 (41%) subjects in the control group and 13 of 15 (87%) subjects in the experimental group achieved a fourfold or greater increase in serum antibody titer to A/Beijing (P=.012). Lymphocyte proliferation to influenza vaccine components was greater in the experimental (median=1,365 cpm, range=0–14,955 cpm) than the control group (median=136 cpm, range=0–4,270 cpm) (P=.013). Conclusion: Subjects consuming an experimental nutritional formula experienced enhanced immune function and fewer days of URTI symptoms.
Bibliography:	istex:7C0381D38AAEC74A99DF1BA0CA7D90B18B5712C8 ArticleID:JGS52003 ark:/67375/WNG-FW72Z893-6 Nutritional Formula Enhanced Immune Function and Reduced Upper Respiratory Tract Infection (URTI) Symptoms in a Randomized, Double‐Blind, Controlled Trial in Older Adults This paper was presented in part at the 2001 meeting of Experimental Biology, Orlando, Florida. Langkamp‐Henken B, Bender BS, Gardner EM, Herrlinger‐Garcia KA, Kelley MJ, McEwen J, Murasko DM, Schaller JP, Simpson JM, Stechmiller JK, Thomas D, Wood SM. F.A.S.E.B.J. 2001;15:A63 and at the International Conference on Immunology and Aging, June 16, 2002, Washington DC. Supported by Ross Products Division/Abbott Laboratories. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 ObjectType-News-3
ISSN:	0002-8614 1532-5415
DOI:	10.1111/j.1532-5415.2004.52003.x