Search Results - "Schaible, Alexander"

Size matters: Effect of granule size of the bone graft substitute (Herafill®) on bone healing using Masquelet's induced membrane in a critical size defect model in the rat's femur by Leiblein, Maximilian, Koch, Elias, Winkenbach, Andreas, Schaible, Alexander, Nau, Christoph, Büchner, Hubert, Schröder, Katrin, Marzi, Ingo, Henrich, Dirk

“…The Masquelet technique for the treatment of large bone defects is a two‐stage procedure based on an induced membrane. The size of a scaffold is reported to be…”
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Oxidative stress-driven pulmonary inflammation and fibrosis in a mouse model of human ataxia-telangiectasia by Duecker, Ruth, Baer, Patrick, Eickmeier, Olaf, Strecker, Maja, Kurz, Jennifer, Schaible, Alexander, Henrich, Dirk, Zielen, Stefan, Schubert, Ralf

“…Lung failure is responsible for significant morbidity and is a frequent cause of death in ataxia-telangiectasia (A-T). Disturbance in the redox balance of…”
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Cell-based therapy by implanted human bone marrow-derived mononuclear cells improved bone healing of large bone defects in rats by Seebach, Caroline, Henrich, Dirk, Schaible, Alexander, Relja, Borna, Jugold, Manfred, Bönig, Halvard, Marzi, Ingo

“…QUESTION/AIM: Cell-based therapy by cultivated stem cells (mesenchymal stem cells [MSC] and endothelial progenitor cells [EPC]) in a large-sized bone defect…”
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Introduction of a New Surgical Method to Improve Bone Healing in a Large Bone Defect by Replacement of the Induced Membrane by a Human Decellularized Dermis Repopulated with Bone Marrow Mononuclear Cells in Rat by Leiblein, Maximilian, Kolb, Tobias, Christian, Lion, Schröder, Katrin, Yaman, Ceyhan, Schaible, Alexander, Marzi, Ingo, Henrich, Dirk, Janko, Maren

“…The Masquelet technique for the treatment of large bone defects is a two-stage procedure based on an induced membrane. We eliminate the first surgical step by…”
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High calcium bioglass enhances differentiation and survival of endothelial progenitor cells, inducing early vascularization in critical size bone defects by Eldesoqi, Karam, Seebach, Caroline, Nguyen Ngoc, Christina, Meier, Simon, Nau, Christoph, Schaible, Alexander, Marzi, Ingo, Henrich, Dirk

“…Early vascularization is a prerequisite for successful bone healing and endothelial progenitor cells (EPC), seeded on appropriate biomaterials, can improve…”
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The Impact of Defect Size on Bone Healing in Critical-Size Bone Defects Investigated on a Rat Femur Defect Model Comparing Two Treatment Methods by Kammerer, Andreas, Hartmann, Frederik Alexander, Nau, Christoph, Leiblein, Maximilian, Schaible, Alexander, Neijhoft, Jonas, Henrich, Dirk, Verboket, René, Janko, Maren

“…Critical-size bone defects up to 25 cm can be treated successfully using the induced membrane technique established by Masquelet. To shorten this procedure,…”
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First Human Leucocyte Antigen (HLA) Response and Safety Evaluation of Fibrous Demineralized Bone Matrix in a Critical Size Femoral Defect Model of the Sprague-Dawley Rat by Söhling, Nicolas, Leiblein, Maximilian, Schaible, Alexander, Janko, Maren, Schwäble, Joachim, Seidl, Christian, Brune, Jan C., Nau, Christoph, Marzi, Ingo, Henrich, Dirk, Verboket, René D.

“…Treatment of large bone defects is one of the great challenges in contemporary orthopedic and traumatic surgery. Grafts are necessary to support bone healing…”
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Pretreatment of Mesenchymal Stem Cells with Electrical Stimulation as a Strategy to Improve Bone Tissue Engineering Outcomes by Bianconi, Santiago, Oliveira, Karla M. C, Klein, Kari-Leticia, Wolf, Jakob, Schaible, Alexander, Schröder, Katrin, Barker, John, Marzi, Ingo, Leppik, Liudmila, Henrich, Dirk

“…Electrical stimulation (EStim), whether used alone or in combination with bone tissue engineering (BTE) approaches, has been shown to promote bone healing. In…”
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One Stage Masquelets Technique: Evaluation of Different Forms of Membrane Filling with and without Bone Marrow Mononuclear Cells (BMC) in Large Femoral Bone Defects in Rats by Söhling, Nicolas, Heilani, Myriam, Fremdling, Charlotte, Schaible, Alexander, Schröder, Katrin, Brune, Jan C, Eras, Volker, Nau, Christoph, Marzi, Ingo, Henrich, Dirk, Verboket, René D

“…The classic two-stage masquelet technique is an effective procedure for the treatment of large bone defects. Our group recently showed that one surgery could…”
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Fibrous Demineralized Bone Matrix (DBM) Improves Bone Marrow Mononuclear Cell (BMC)-Supported Bone Healing in Large Femoral Bone Defects in Rats by Verboket, René D, Irrle, Tanja, Busche, Yannic, Schaible, Alexander, Schröder, Katrin, Brune, Jan C, Marzi, Ingo, Nau, Christoph, Henrich, Dirk

“…Regeneration of large bone defects is a major objective in trauma surgery. Bone marrow mononuclear cell (BMC)-supported bone healing was shown to be efficient…”
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The Induced Membrane Technique-The Filling Matters: Evaluation of Different Forms of Membrane Filling with and without Bone Marrow Mononuclear Cells (BMC) in Large Femoral Bone Defects in Rats by Verboket, René D, Söhling, Nicolas, Heilani, Myriam, Fremdling, Charlotte, Schaible, Alexander, Schröder, Katrin, Brune, Jan C, Marzi, Ingo, Henrich, Dirk

“…The Masquelet technique is used to treat large bone defects; it is a two-stage procedure based on an induced membrane. To improve the induced membrane process,…”
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Alteration of Masquelet's induced membrane characteristics by different kinds of antibiotic enriched bone cement in a critical size defect model in the rat's femur by Nau, Christoph, Seebach, Caroline, Trumm, Alexander, Schaible, Alexander, Kontradowitz, Kerstin, Meier, Simon, Buechner, Hubert, Marzi, Ingo, Henrich, Dirk

“…Abstract The Masquelet technique for the treatment of large bone defects consists of a 2-stage procedure. In the first stage, a polymethylmethacrylate (PMMA)…”
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Longitudinal Testing for Respiratory and Gastrointestinal Shedding of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Day Care Centers in Hesse, Germany by Hoehl, Sebastian, Kreutzer, Emilie, Schenk, Barbara, Westhaus, Sandra, Foppa, Ivo, Herrmann, Eva, Ettrich, India, Leondaraki, Maria, Schaible, Alexander, Rudych, Olga, Rabenau, Holger, Berger, Annemarie, Ciesek, Sandra

“…Abstract Background With the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ongoing in Europe in June 2020, day care centers were…”
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Influence of the induced membrane filled with syngeneic bone and regenerative cells on bone healing in a critical size defect model of the rat’s femur by Nau, Christoph, Simon, Sebastian, Schaible, Alexander, Seebach, Caroline, Schröder, Katrin, Marzi, Ingo, Henrich, Dirk

“…The induced membrane technique for the treatment of large bone defects consists of a 2-stage procedure. In the first stage, a polymethylmethacrylate (PMMA)…”
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Longitudinal testing for respiratory and gastrointestinal shedding of SARS-CoV-2 in day care centres in Hesse, Germany by Hoehl, Sebastian, Kreutzer, Emilie, Schenk, Barbara, Westhaus, Sandra, Foppa, Ivo, Herrmann, Eva, Ettrich, India, Leondaraki, Maria, Schaible, Alexander, Rudych, Olga, Rabenau, Holger, Berger, Annemarie, Ciesek, Sandra

“…With the pandemic of SARS-CoV-2 ongoing in Europe in June of 2020, day care centres were reopened in the state of Hesse, Germany, after the lockdown. The role…”
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Comparison of three different types of scaffolds preseeded with human bone marrow mononuclear cells on the bone healing in a femoral critical size defect model of the athymic rat by Janko, Maren, Sahm, Julian, Schaible, Alexander, Brune, Jan C., Bellen, Marlene, Schroder, Katrin, Seebach, Caroline, Marzi, Ingo, Henrich, Dirk

“…Large bone defects often pose major difficulties in orthopaedic surgery. The application of long‐term cultured stem cells combined with a scaffold lead to a…”
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Impact of scaffold granule size use in Masquelet technique on periosteal reaction: a study in rat femur critical size bone defect model by Leiblein, Maximilian, Winkenbach, Andreas, Koch, Elias, Schaible, Alexander, Büchner, Hubert, Marzi, Ingo, Henrich, Dirk, Nau, Christoph

“…Purpose The Masquelet technique for the treatment of large bone defects is a two-stage procedure based on an induced membrane. Compared to mature periosteum,…”
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Characterization of Bone Marrow Mononuclear Cells on Biomaterials for Bone Tissue Engineering In Vitro by Marzi, Ingo, Seebach, Caroline, Bonig, Halvard, Nau, Christoph, Brune, Jan C., Oppermann, Elsie, Kontradowitz, K., Schaible, Alexander, Verboket, René, Henrich, Dirk, Meier, Simon

“…Bone marrow mononuclear cells (BMCs) are suitable for bone tissue engineering. Comparative data regarding the needs of BMC for the adhesion on biomaterials and…”
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Pre- or post-treatment with ethanol and ethyl pyruvate results in distinct anti-inflammatory responses of human lung epithelial cells triggered by interleukin-6 by RELJA, BORNA, OMID, NINA, SCHAIBLE, ALEXANDER, PERL, MARIO, MEIER, SIMON, OPPERMANN, ELSIE, LEHNERT, MARK, MARZI, INGO

“…Increased local and systemic levels of interleukin (IL)-6 are associated with inflammatory processes, including neutrophil infiltration of the alveolar space,…”
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From two stages to one: acceleration of the induced membrane (Masquelet) technique using human acellular dermis for the treatment of non-infectious large bone defects by Verboket, René Danilo, Leiblein, Maximilian, Janko, Maren, Schaible, Alexander, Brune, Jan Claas, Schröder, Katrin, Heilani, Myriam, Fremdling, Charlotte, Busche, Yannic, Irrle, Tanja, Marzi, Ingo, Nau, Christoph, Henrich, Dirk

“…Introduction The induced membrane technique for the treatment of large bone defects is a two-step procedure. In the first operation, a foreign body membrane is…”
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