Search Results - "Schaffer, D"

Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models by Andrus, B M, Blizinsky, K, Vedell, P T, Dennis, K, Shukla, P K, Schaffer, D J, Radulovic, J, Churchill, G A, Redei, E E

“…The etiology of depression is still poorly understood, but two major causative hypotheses have been put forth: the monoamine deficiency and the stress…”
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Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates by Kotterman, M A, Yin, L, Strazzeri, J M, Flannery, J G, Merigan, W H, Schaffer, D V

“…Gene delivery vectors based on adeno-associated viruses (AAV) have exhibited promise in both preclinical disease models and human clinical trials for numerous…”
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Professionalisierung der Anästhesiepflege in Österreich: Ein Gedankenexperiment nach dem Vorbild der Certified Registered Nurse Anesthetists (CRNA) in den USA by Schaffer, D.

“…Doch die Zeit ist reif, um über den „lieb gewordenen“ Tellerrand hinauszublicken und die Zukunft der institutionellen Akutversorgung erkrankter Personen im…”
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Directed evolution of novel adeno-associated viruses for therapeutic gene delivery by Bartel, M A, Weinstein, J R, Schaffer, D V

“…Gene therapy vectors based on adeno-associated virus (AAV) are currently in clinical trials for numerous disease targets, such as muscular dystrophy,…”
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Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering by Bugaj, L. J., Spelke, D. P., Mesuda, C. K., Varedi, M., Kane, R. S., Schaffer, D. V.

“…Transmembrane receptors are the predominant conduit through which cells sense and transduce extracellular information into intracellular biochemical signals…”
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Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h−/− mouse by Byrne, L C, Öztürk, B E, Lee, T, Fortuny, C, Visel, M, Dalkara, D, Schaffer, D V, Flannery, J G

“…X-linked retinoschisis, a disease characterized by splitting of the retina, is caused by mutations in the retinoschisin gene, which encodes a putative secreted…”
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AAV ancestral reconstruction library enables selection of broadly infectious viral variants by Santiago-Ortiz, J, Ojala, D S, Westesson, O, Weinstein, J R, Wong, S Y, Steinsapir, A, Kumar, S, Holmes, I, Schaffer, D V

“…Adeno-associated virus (AAV) vectors have achieved clinical efficacy in treating several diseases. However, enhanced vectors are required to extend these…”
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Antimicrobial Activity of Clinically Isolated Bacterial Species Against Staphylococcus aureus by Hardy, Britney L, Bansal, Garima, Hewlett, Katharine H, Arora, Arshia, Schaffer, Scott D, Kamau, Edwin, Bennett, Jason W, Merrell, D Scott

“…Bacteria often exist in polymicrobial communities where they compete for limited resources. Intrinsic to this competition is the ability of some species to…”
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Landscape Pollution Source Dynamics Highlight Priority Locations for Basin‐Scale Interventions to Protect Water Quality Under Hydroclimatic Variability by Schaffer‐Smith, D., DeMeester, J. E., Tong, D., Myint, S. W., Libera, D. A., Muenich, R. L.

“…Extreme weather is associated with a variety of water quality issues that can pose harm to humans and aquatic ecosystems. Under dry conditions, contaminants…”
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Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9 by Dalkara, D, Byrne, L C, Lee, T, Hoffmann, N V, Schaffer, D V, Flannery, J G

“…Delivery of therapeutic genes to a large region of the retina with minimal damage from intraocular surgery is a central goal of treatment for retinal…”
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Periconceptional Dietary Intake of Choline and Betaine and Neural Tube Defects in Offspring by Shaw, Gary M., Carmichael, Suzan L., Yang, Wei, Selvin, Steve, Schaffer, Donna M.

“…Periconceptional intake of folic acid prevents some neural tube defects (NTDs). Other nutrients may also contribute to NTD etiologies; a likely candidate is…”
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Antiviral RNAi therapy: emerging approaches for hitting a moving target by Leonard, J N, Schaffer, D V

“…The field of directed RNA interference (RNAi) has rapidly developed into a highly promising approach for specifically down regulating genes to alleviate…”
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Engineering a serum-resistant and thermostable vesicular stomatitis virus G glycoprotein for pseudotyping retroviral and lentiviral vectors by Hwang, B-Y, Schaffer, D V

“…Vesicular stomatitis virus G glycoprotein (VSV-G) is the most widely used envelope protein for retroviral and lentiviral vector pseudotyping; however, serum…”
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Frontiers in aging special issue: DNA repair and interventions in aging perspective on "loss of epigenetic information as a cause of mammalian aging" by Schaffer, Ethan D, Beerman, Isabel, de Cabo, Rafael, Brosh, Jr, Robert M

“…The recently published article in by the Sinclair lab and collaborators entitled "Loss of Epigenetic Information as a Cause of Mammalian Aging" [1] implicates…”
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Neuronal Nogo-A upregulation does not contribute to ER stress-associated apoptosis but participates in the regenerative response in the axotomized adult retina by Pernet, V, Joly, S, Dalkara, D, Schwarz, O, Christ, F, Schaffer, D, Flannery, J G, Schwab, M E

“…Nogo-A, an axonal growth inhibitory protein known to be mostly present in CNS myelin, was upregulated in retinal ganglion cells (RGCs) after optic nerve injury…”
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Replication stress as a driver of cellular senescence and aging by Herr, Lauren M., Schaffer, Ethan D., Fuchs, Kathleen F., Datta, Arindam, Brosh, Robert M.

“…Replication stress refers to slowing or stalling of replication fork progression during DNA synthesis that disrupts faithful copying of the genome. While long…”
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Severe colchicine poisoning treated successfully with kidney replacement therapy and plasmapheresis: a case report by Schaffer, D H, Overbeek, D L, Erickson, T B, Boyer, E W, Goldfine, C, Muhsin, S A, Chai, P R

“…Colchicine is commonly prescribed for treatment of inflammatory conditions but has a narrow therapeutic window and dangerous toxicity profile. Here we describe…”
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Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery by Schaffer, David V., Fidelman, Nick A., Dan, Nily, Lauffenburger, Douglas A.

“…Ligand‐conjugated polymer (polyplex) gene delivery vectors have strong potential as targeted, in vivo gene transfer vehicles; however, they are currently…”
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A review of smoking cessation: potentially risky effects on prescribed medications by Schaffer, Susan D, Yoon, Saunjoo, Zadezensky, Immo

“…Aims and objectives.  To identify prescription drugs that require dosage adjustment or monitoring in patients who quit smoking and to provide recommendations…”
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Evaluation of ophthalmic and hemodynamic parameters in capuchin monkeys (Sapajus sp.) submitted to dissociative anesthetic protocols by Raposo, A.C.S., Ofri, R., Schaffer, D.P.H., Gomes Júnior, D.C., Libório, F.A., Martins Filho, E.F., Oriá, A.P.

“…Background Dissociative drugs are used for chemical restraint in monkeys. The aim was to evaluate muscle relaxation, recovery, and ophthalmic and hemodynamic…”
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