Search Results - "Schaffer, Chris B."

In vivo three-photon microscopy of subcortical structures within an intact mouse brain by Horton, Nicholas G., Wang, Ke, Kobat, Demirhan, Clark, Catharine G., Wise, Frank W., Schaffer, Chris B., Xu, Chris

“…Two-photon fluorescence microscopy 1 enables scientists in various fields including neuroscience 2 , 3 , embryology 4 and oncology 5 to visualize in vivo and…”
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Causes and consequences of baseline cerebral blood flow reductions in Alzheimer’s disease by Bracko, Oliver, Cruz Hernández, Jean C, Park, Laibaik, Nishimura, Nozomi, Schaffer, Chris B

“…Reductions of baseline cerebral blood flow (CBF) of ∼10–20% are a common symptom of Alzheimer’s disease (AD) that appear early in disease progression and…”
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Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation by Ahn, Sung Ji, Anrather, Josef, Nishimura, Nozomi, Schaffer, Chris B

“…BACKGROUND AND PURPOSE—Cerebral microbleeds are linked to cognitive decline, but it remains unclear how they impair neuronal function. Infarction is not…”
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TRAIL-coated leukocytes that kill cancer cells in the circulation by Mitchell, Michael J., Wayne, Elizabeth, Rana, Kuldeepsinh, Schaffer, Chris B., King, Michael R.

“…Metastasis through the bloodstream contributes to poor prognosis in many types of cancer. Mounting evidence implicates selectin-based adhesive interactions…”
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Deep convolutional neural networks for segmenting 3D in vivo multiphoton images of vasculature in Alzheimer disease mouse models by Haft-Javaherian, Mohammad, Fang, Linjing, Muse, Victorine, Schaffer, Chris B, Nishimura, Nozomi, Sabuncu, Mert R

“…The health and function of tissue rely on its vasculature network to provide reliable blood perfusion. Volumetric imaging approaches, such as multiphoton…”
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Deep tissue multiphoton microscopy using longer wavelength excitation by Kobat, Demirhan, Durst, Michael E, Nishimura, Nozomi, Wong, Angela W, Schaffer, Chris B, Xu, Chris

“…We compare the maximal two-photon fluorescence microscopy (TPM) imaging depth achieved with 775-nm excitation to that achieved with 1280-nm excitation through…”
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Quasi-analytic solution for real-time multi-exposure speckle imaging of tissue perfusion by Rivera, Daniel A, Schaffer, Chris B

“…Laser speckle contrast imaging (LSCI) is a widefield imaging technique that enables high spatiotemporal resolution measurement of blood flow. Laser coherence,…”
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Two-Photon Microscopy as a Tool to Study Blood Flow and Neurovascular Coupling in the Rodent Brain by Shih, Andy Y, Driscoll, Jonathan D, Drew, Patrick J, Nishimura, Nozomi, Schaffer, Chris B, Kleinfeld, David

“…The cerebral vascular system services the constant demand for energy during neuronal activity in the brain. Attempts to delineate the logic of neurovascular…”
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Dynamic capillary stalls in reperfused ischemic penumbra contribute to injury: A hyperacute role for neutrophils in persistent traffic jams by Erdener, Şefik E, Tang, Jianbo, Kılıç, Kıvılcım, Postnov, Dmitry, Giblin, John T, Kura, Sreekanth, Chen, I-chun A, Vayisoğlu, Tuğberk, Sakadžić, Sava, Schaffer, Chris B, Boas, David A

“…Ever since the introduction of thrombolysis and the subsequent expansion of endovascular treatments for acute ischemic stroke, it remains to be identified why…”
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In Vivo Imaging of Myelin in the Vertebrate Central Nervous System Using Third Harmonic Generation Microscopy by Farrar, Matthew J., Wise, Frank W., Fetcho, Joseph R., Schaffer, Chris B.

“…Loss of myelin in the central nervous system (CNS) leads to debilitating neurological deficits. High-resolution optical imaging of myelin in the CNS of animal…”
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Vascular contributions to cognitive impairment and dementia including Alzheimer's disease by Snyder, Heather M, Corriveau, Roderick A, Craft, Suzanne, Faber, James E, Greenberg, Steven M, Knopman, David, Lamb, Bruce T, Montine, Thomas J, Nedergaard, Maiken, Schaffer, Chris B, Schneider, Julie A, Wellington, Cheryl, Wilcock, Donna M, Zipfel, Gregory J, Zlokovic, Berislav, Bain, Lisa J, Bosetti, Francesca, Galis, Zorina S, Koroshetz, Walter, Carrillo, Maria C

“…Abstract Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease…”
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Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop by Zlokovic, Berislav V., Gottesman, Rebecca F., Bernstein, Kenneth E., Seshadri, Sudha, McKee, Ann, Snyder, Heather, Greenberg, Steven M., Yaffe, Kristine, Schaffer, Chris B., Yuan, Chun, Hughes, Timothy M., Daemen, Mat J., Williamson, Jeff D., González, Hector M., Schneider, Julie, Wellington, Cheryl L., Katusic, Zvonimir S., Stoeckel, Luke, Koenig, James I., Corriveau, Roderick A., Fine, Lawrence, Galis, Zorina S., Reis, Jared, Wright, Jacqueline D., Chen, Jue

“…Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope…”
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MousePZT: A simple, reliable, low-cost device for vital sign monitoring and respiratory gating in mice under anesthesia by Rivera, Daniel A, Buglione, Anne E, Ray, Sadie E, Schaffer, Chris B

“…Small animal studies in biomedical research often require anesthesia to reduce pain or stress experienced by research animals and to minimize motion artifact…”
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Ultra-large field-of-view two-photon microscopy by Tsai, Philbert S, Mateo, Celine, Field, Jeffrey J, Schaffer, Chris B, Anderson, Matthew E, Kleinfeld, David

“…We present a two-photon microscope that images the full extent of murine cortex with an objective-limited spatial resolution across an 8 mm by 10 mm field. The…”
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Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration by Huynh, John, Nishimura, Nozomi, Rana, Kuldeepsinh, Peloquin, John M, Califano, Joseph P, Montague, Christine R, King, Michael R, Schaffer, Chris B, Reinhart-King, Cynthia A

“…Age is the most significant risk factor for atherosclerosis; however, the link between age and atherosclerosis is poorly understood. During both aging and…”
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Optoporation and Genetic Manipulation of Cells Using Femtosecond Laser Pulses by Davis, Andrew A., Farrar, Matthew J., Nishimura, Nozomi, Jin, Moonsoo M., Schaffer, Chris B.

“…Femtosecond laser optoporation is a powerful technique to introduce membrane-impermeable molecules, such as DNA plasmids, into targeted cells in culture, yet…”
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Chronic in vivo imaging in the mouse spinal cord using an implanted chamber by Farrar, Matthew J, Bernstein, Ida M, Schlafer, Donald H, Cleland, Thomas A, Fetcho, Joseph R, Schaffer, Chris B

“…An imaging chamber implanted over the mouse spinal cord enables long-term longitudinal two-photon microscopy of cellular dynamics in normal or pathological…”
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Line-scanning particle image velocimetry: an optical approach for quantifying a wide range of blood flow speeds in live animals by Kim, Tyson N, Goodwill, Patrick W, Chen, Yeni, Conolly, Steven M, Schaffer, Chris B, Liepmann, Dorian, Wang, Rong A

“…The ability to measure blood velocities is critical for studying vascular development, physiology, and pathology. A key challenge is to quantify a wide range…”
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Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels by Murphy, Patrick A., Kim, Tyson N., Huang, Lawrence, Nielsen, Corinne M., Lawton, Michael T., Adams, Ralf H., Schaffer, Chris B., Wang, Rong A.

“…Significance Brain arteriovenous malformations are focal lesions of enlarged, tangled vessels that shunt blood from arteries directly to veins. They can cause…”
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Penetrating arterioles are a bottleneck in the perfusion of neocortex by Nishimura, Nozomi, Schaffer, Chris B, Friedman, Beth, Lyden, Patrick D, Kleinfeld, David

“…Penetrating arterioles bridge the mesh of communicating arterioles on the surface of cortex with the subsurface microvascular bed that feeds the underlying…”
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