Phase I trial of Staphylococcus aureus Cowan I immunoperfusion

Staphylococcus aureus Cowan I has shown antitumor activity in in vitro and in animal tumor models. It is hypothesized that this antineoplastic effect results from the interaction of protein A on the cell surface of Cowan I strain S. aureus and immunosuppressive circulating immune complexes. Therefor...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer treatment reports Vol. 66; no. 12; p. 2027
Main Authors:	Messerschmidt, G, Bowles, C, Dean, D, Parker, M, Lester, R, Dowling, R, Holohan, T, Osborne, L, Schaff, B F, McCormack, K, Corbitt, R, Phillips, T, Glatstein, E, Deisseroth, A
Format:	Journal Article
Language:	English
Published:	United States 01-01-1982
Subjects:	Adult Aged Evaluation Studies as Topic Humans Immunotherapy Middle Aged Neoplasms - therapy Perfusion Respiration Staphylococcal Protein A - therapeutic use Time Factors
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Staphylococcus aureus Cowan I has shown antitumor activity in in vitro and in animal tumor models. It is hypothesized that this antineoplastic effect results from the interaction of protein A on the cell surface of Cowan I strain S. aureus and immunosuppressive circulating immune complexes. Therefore, we treated five patients with ex vivo plasma immuno-perfusion over killed and fixed S. aureus Cowan I. Toxic effects were marked in all patients and appeared to be related to the plasma volume infused and rate of infusion. Toxic reactions occurred in the cardiovascular, respiratory, and hematopoietic systems. No responses even minimal or transient, were observed in this phase I trial. This toxicity may be reduced if the rate of plasma infusion decreases.
ISSN:	0361-5960