Search Results - "Schafer, P.H."

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity by Schafer, P.H., Parton, A., Capone, L., Cedzik, D., Brady, H., Evans, J.F., Man, H.-W., Muller, G.W., Stirling, D.I., Chopra, R.

“…Apremilast, an oral small molecule inhibitor of phosphodiesterase 4 (PDE4), is in development for chronic inflammatory disorders, and has shown efficacy in…”
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Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide by Lopez-Girona, A, Mendy, D, Ito, T, Miller, K, Gandhi, A K, Kang, J, Karasawa, S, Carmel, G, Jackson, P, Abbasian, M, Mahmoudi, A, Cathers, B, Rychak, E, Gaidarova, S, Chen, R, Schafer, P H, Handa, H, Daniel, T O, Evans, J F, Chopra, R

“…Thalidomide and the immunomodulatory drug, lenalidomide, are therapeutically active in hematological malignancies. The ubiquitously expressed E3 ligase protein…”
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Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide by Lopez-Girona, A, Mendy, D, Ito, T, Miller, K, Gandhi, A.K, Kang, J, Karasawa, S, Carmel, G, Jackson, P, Abbasian, M, Mahmoudi, A, Cathers, B, Rychak, E, Gaidarova, S, Chen, R, Schafer, P.H, Handa, H, Daniel, T.O, Evans, J.F, Chopra, R

“…Thalidomide and the immunomodulatory drug, lenalidomide, are therapeutically active in hematological malignancies. The ubiquitously expressed E3 ligase protein…”
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O-40 Lenalidomide inhibits proliferation of chromosome 5 mutant hematopoietic tumor cells and interferes with adaptor protein complex assembly and phosphorylation by Krithivas Gandhi, A., Schafer, P.H., Naziruddin, S., Parton, A., Verhelle, D., Brady, H., Stirling, D.I.

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Synthesis of alpha, beta-deuterated 15N amino acids using a coupled glutamate dehydrogenase-branched-chain amino acid aminotransferase system by Chanatry, J A, Schafer, P H, Kim, M S, LeMaster, D M

“…Gram amounts of various 15N-enriched L-amino acids have been synthesized using a coupled enzymatic system. Catalytic amounts of 15N-labeled L-glutamate are…”
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