Search Results - "Schafer, Christopher M"

Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge by Schafer, Christopher M., Martin-Almedina, Silvia, Kurylowicz, Katarzyna, Dufton, Neil, Osuna-Almagro, Lourdes, Wu, Meng-Ling, Johnson, Charmain F., Shah, Aarti V., Haskard, Dorian O., Buxton, Andrianna, Willis, Erika, Wheeler, Kate, Turner, Sean, Chlebicz, Magdalena, Scott, Rizaldy P., Kovats, Susan, Cleuren, Audrey, Birdsey, Graeme M., Randi, Anna M., Griffin, Courtney T.

“…During infectious diseases, proinflammatory cytokines transiently destabilize interactions between adjacent vascular endothelial cells (ECs) to facilitate the…”
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Rapid screening of sugar-nucleotide donor specificities of putative glycosyltransferases by Sheikh, M Osman, Halmo, Stephanie M, Patel, Sneha, Middleton, Dustin, Takeuchi, Hideyuki, Schafer, Christopher M, West, Christopher M, Haltiwanger, Robert S, Avci, Fikri Y, Moremen, Kelley W, Wells, Lance

“…Determining the correct enzymatic activity of putative glycosyltransferases (GTs) can be challenging as these enzymes can utilize multiple donor and acceptor…”
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Deficient RPE mitochondrial energetics leads to subretinal fibrosis in age-related neovascular macular degeneration by Ma, Xiang, Wu, Wenjing, Hara, Miwa, Zhou, Junwen, Panzarin, Carolina, Schafer, Christopher M., Griffin, Courtney T., Cai, Jiyang, Ma, Jian-Xing, Takahashi, Yusuke

“…Subretinal fibrosis permanently impairs the vision of patients with neovascular age-related macular degeneration. Despite emerging evidence revealing the…”
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Comparative analysis of In vivo endothelial cell translatomes across central nervous system vascular beds by Chucair-Elliott, Ana J., Pham, Kevin, Cleuren, Audrey C.A., Schafer, Christopher M., Griffin, Courtney T., Ocanas, Sarah R., Freeman, Willard M., Elliott, Michael H.

“…Endothelial cells (ECs) display organ- and tissue-specific heterogeneity. In the eye, the retinal and choroidal vascular beds are distinct networks with…”
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An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression by Schafer, Christopher M., Gurley, Jami M., Kurylowicz, Katarzyna, Lin, Prisca K., Chen, Wen, Elliott, Michael H., Davis, George E., Bhatti, Faizah, Griffin, Courtney T.

“…During the progression of ocular diseases such as retinopathy of prematurity and diabetic retinopathy, overgrowth of retinal blood vessels results in the…”
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Oxygen-dependent regulation of E3(SCF)ubiquitin ligases and a Skp1-associated JmjD6 homolog in development of the social amoeba Dictyostelium by Boland, Andrew W., Gas-Pascual, Elisabet, Nottingham, Braxton L., van der Wel, Hanke, Sheikh, M. Osman, Schafer, Christopher M., West, Christopher M.

“…E3-SCF (Skp1/cullin-1/F-box protein) polyubiquitin ligases activate the proteasomal degradation of over a thousand proteins, but the evolutionary…”
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O2 sensing–associated glycosylation exposes the F-box–combining site of the Dictyostelium Skp1 subunit in E3 ubiquitin ligases by Sheikh, M. Osman, Thieker, David, Chalmers, Gordon, Schafer, Christopher M., Ishihara, Mayumi, Azadi, Parastoo, Woods, Robert J., Glushka, John N., Bendiak, Brad, Prestegard, James H., West, Christopher M.

“…Skp1 is a conserved protein linking cullin-1 to F-box proteins in SCF (Skp1/Cullin-1/F-box protein) E3 ubiquitin ligases, which modify protein substrates with…”
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Novel Regulation of Skp1 by the Dictyostelium AgtA α-Galactosyltransferase Involves the Skp1-binding Activity of Its WD40 Repeat Domain by Schafer, Christopher M., Sheikh, M.Osman, Zhang, Dongmei, West, Christopher M.

“…The role of Skp1 as an adaptor protein that links Cullin-1 to F-box proteins in E3 Skp1/Cullin-1/F-box protein (SCF) ubiquitin ligases is well characterized…”
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Chemical Synthesis of a Glycopeptide Derived from Skp1 for Probing Protein Specific Glycosylation by Chinoy, Zoeisha S., Schafer, Christopher M., West, Christopher M., Boons, Geert-Jan

“…Skp1 is a cytoplasmic and nuclear protein, best known as an adaptor of the SCF family of E3‐ubiquitin ligases that label proteins for their degradation. Skp1…”
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Glycosylation of Skp1 Affects Its Conformation and Promotes Binding to a Model F‑Box Protein by Sheikh, M. Osman, Schafer, Christopher M, Powell, John T, Rodgers, Karla K, Mooers, Blaine H. M, West, Christopher M

“…In the social amoeba Dictyostelium, Skp1 is hydroxylated on proline 143 and further modified by three cytosolic glycosyltransferases to yield an O-linked…”
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O 2 sensing-associated glycosylation exposes the F-box-combining site of the Dictyostelium Skp1 subunit in E3 ubiquitin ligases by Sheikh, M Osman, Thieker, David, Chalmers, Gordon, Schafer, Christopher M, Ishihara, Mayumi, Azadi, Parastoo, Woods, Robert J, Glushka, John N, Bendiak, Brad, Prestegard, James H, West, Christopher M

“…Skp1 is a conserved protein linking cullin-1 to F-box proteins in SCF ( kp1/ ullin-1/ -box protein) E3 ubiquitin ligases, which modify protein substrates with…”
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Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge by Schafer, Christopher M., Martin-Almedina, Silvia, Kurylowicz, Katarzyna, Dufton, Neil, Osuna-Almagro, Lourdes, Wu, Meng-Ling, Johnson, Charmain F., Shah, Aarti V., Haskard, Dorian O., Buxton, Andrianna, Willis, Erika, Wheeler, Kate, Turner, Sean, Chlebicz, Magdalena, Scott, Rizaldy P., Kovats, Susan, Cleuren, Audrey, Birdsey, Graeme M., Randi, Anna M., Griffin, Courtney T.

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Nonenzymatic and Enzymatic Functions of the Skp1 αGalactosyltransferase in Dictyostelium Oxygen‐Sensing by Schafer, Christopher M., Zhang, Dongmei, West, Christopher M.

“…Abstract only In the social amoeba Dictyostelium discoideum the SCF E3 adaptor protein Skp1 is modified by a prolyl hydroxylase and three glycosyltransferases…”
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