Search Results - "Schafer, Beat W."

Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma by Böhm, Maria, Wachtel, Marco, Marques, Joana G, Streiff, Natalie, Laubscher, Dominik, Nanni, Paolo, Mamchaoui, Kamel, Santoro, Raffaella, Schäfer, Beat W

“…A vast number of cancer genes are transcription factors that drive tumorigenesis as oncogenic fusion proteins. Although the direct targeting of transcription…”
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Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death by Ommer, Johannes, Selfe, Joanna L, Wachtel, Marco, O'Brien, Eleanor M, Laubscher, Dominik, Roemmele, Michaela, Kasper, Stephanie, Delattre, Olivier, Surdez, Didier, Petts, Gemma, Kelsey, Anna, Shipley, Janet, Schäfer, Beat W

“…The clinically aggressive alveolar rhabdomyosarcoma (RMS) subtype is characterized by expression of the oncogenic fusion protein PAX3-FOXO1, which is critical…”
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The Chromatin Remodeler CHD4 Sustains Ewing Sarcoma Cell Survival by Controlling Global Chromatin Architecture by Graca Marques, Joana, Pavlovic, Blaz, Ngo, Quy A, Pedot, Gloria, Roemmele, Michaela, Volken, Larissa, Kisele, Samanta, Perbet, Romain, Wachtel, Marco, Schäfer, Beat W

“…Ewing sarcoma is an aggressive cancer with a defective response to DNA damage leading to an enhanced sensitivity to genotoxic agents. Mechanistically, Ewing…”
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Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance by Bonapace, Laura, Bornhauser, Beat C, Schmitz, Maike, Cario, Gunnar, Ziegler, Urs, Niggli, Felix K, Schäfer, Beat W, Schrappe, Martin, Stanulla, Martin, Bourquin, Jean-Pierre

“…In vivo resistance to first-line chemotherapy, including to glucocorticoids, is a strong predictor of poor outcome in children with acute lymphoblastic…”
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Evaluation of the Role of AXL in Fusion-positive Pediatric Rhabdomyosarcoma Identifies the Small-molecule Inhibitor Bemcentinib (BGB324) as Potent Chemosensitizer by Danielli, Sara G, Wurth, Jakob, Morice, Sarah, Kisele, Samanta, Surdez, Didier, Delattre, Olivier, Bode, Peter K, Wachtel, Marco, Schäfer, Beat W

“…Rhabdomyosarcoma (RMS) is a highly aggressive pediatric cancer with features of skeletal muscle differentiation. More than 80% of the high-risk patients…”
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NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency by Marques, Joana G, Gryder, Berkley E, Pavlovic, Blaz, Chung, Yeonjoo, Ngo, Quy A, Frommelt, Fabian, Gstaiger, Matthias, Song, Young, Benischke, Katharina, Laubscher, Dominik, Wachtel, Marco, Khan, Javed, Schäfer, Beat W

“…The NuRD complex subunit CHD4 is essential for fusion-positive rhabdomyosarcoma (FP-RMS) survival, but the mechanisms underlying this dependency are not…”
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Novel FGFR4-Targeting Single-Domain Antibodies for Multiple Targeted Therapies against Rhabdomyosarcoma by Alijaj, Nagjie, Moutel, Sandrine, Gouveia, Zelia L., Gray, Maxim, Roveri, Maurizio, Dzhumashev, Dzhangar, Weber, Florian, Meier, Gianmarco, Luciani, Paola, Rössler, Jochen K., Schäfer, Beat W., Perez, Franck, Bernasconi, Michele

“…The fibroblast growth factor receptor 4 (FGFR4) is overexpressed in rhabdomyosarcoma (RMS) and represents a promising target for treatments based on specific…”
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MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57Kip2 targeting by Pomella, Silvia, Cassandri, Matteo, D’Archivio, Lucrezia, Porrazzo, Antonella, Cossetti, Cristina, Phelps, Doris, Perrone, Clara, Pezzella, Michele, Cardinale, Antonella, Wachtel, Marco, Aloisi, Sara, Milewski, David, Colletti, Marta, Sreenivas, Prethish, Walters, Zoë S., Barillari, Giovanni, Di Giannatale, Angela, Milano, Giuseppe Maria, De Stefanis, Cristiano, Alaggio, Rita, Rodriguez-Rodriguez, Sonia, Carlesso, Nadia, Vakoc, Christopher R., Velardi, Enrico, Schafer, Beat W., Guccione, Ernesto, Gatz, Susanne A., Wasti, Ajla, Yohe, Marielle, Ignatius, Myron, Quintarelli, Concetta, Shipley, Janet, Miele, Lucio, Khan, Javed, Houghton, Peter J., Marampon, Francesco, Gryder, Berkley E., De Angelis, Biagio, Locatelli, Franco, Rota, Rossella

“…Rhabdomyosarcomas (RMS) are pediatric mesenchymal-derived malignancies encompassing PAX3/7-FOXO1 Fusion Positive (FP)-RMS, and Fusion Negative (FN)-RMS with…”
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FGFR4 signaling couples to Bim and not Bmf to discriminate subsets of alveolar rhabdomyosarcoma cells by Wachtel, Marco, Rakic, Jelena, Okoniewski, Michal, Bode, Peter, Niggli, Felix, Schäfer, Beat W.

“…Biological heterogeneity represents a major obstacle for cancer treatment. Therefore, characterization of treatment‐relevant tumor heterogeneity is necessary…”
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Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance by Danielli, Sara G, Porpiglia, Ermelinda, De Micheli, Andrea J, Navarro, Natalia, Zellinger, Michael J, Bechtold, Ingrid, Kisele, Samanta, Volken, Larissa, Marques, Joana G, Kasper, Stephanie, Bode, Peter K, Henssen, Anton G, Gürgen, Dennis, Delattre, Olivier, Surdez, Didier, Roma, Josep, Bühlmann, Peter, Blau, Helen M, Wachtel, Marco, Schäfer, Beat W

“…Rhabdomyosarcoma (RMS) is a group of pediatric cancers with features of developing skeletal muscle. The cellular hierarchy and mechanisms leading to…”
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Rhabdomyosarcoma: current challenges and their implications for developing therapies by Hettmer, Simone, Li, Zhizhong, Billin, Andrew N, Barr, Frederic G, Cornelison, D D W, Ehrlich, Alan R, Guttridge, Denis C, Hayes-Jordan, Andrea, Helman, Lee J, Houghton, Peter J, Khan, Javed, Langenau, David M, Linardic, Corinne M, Pal, Ranadip, Partridge, Terence A, Pavlath, Grace K, Rota, Rossella, Schäfer, Beat W, Shipley, Janet, Stillman, Bruce, Wexler, Leonard H, Wagers, Amy J, Keller, Charles

“…Rhabdomyosarcoma (RMS) represents a rare, heterogeneous group of mesodermal malignancies with skeletal muscle differentiation. One major subgroup of RMS tumors…”
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Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma by Regina, Carla, Hamed, Ebrahem, Andrieux, Geoffroy, Angenendt, Sina, Schneider, Michaela, Ku, Manching, Follo, Marie, Wachtel, Marco, Ke, Eugene, Kikuchi, Ken, Henssen, Anton G, Schäfer, Beat W, Boerries, Melanie, Wagers, Amy J, Keller, Charles, Hettmer, Simone

“…Rhabdomyosarcomas (RMS) are phenotypically and functionally heterogeneous. Both primary human RMS cultures and low-passage mouse RMS cell lines, which express…”
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PAX3-FOXO1: Zooming in on an “undruggable” target by Wachtel, Marco, Schäfer, Beat W.

“…Driver oncogenes are prime targets for therapy in tumors many of which, including leukemias and sarcomas, express recurrent fusion transcription factors. One…”
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Inverse Expression of S100A4 and E-Cadherin Is Associated with Metastatic Potential in Gastric Cancer by YONEMURA, Yutaka, ENDOU, Yoshio, SCHAFER, Beat W, SASAKI, Takuma, KIMURA, Keiichi, FUSHIDA, Sachio, BANDOU, Etsurou, TANIGUCHI, Keizou, KINOSHITA, Kazuo, NINOMIYA, Itasu, SUGIYAMA, Kazuo, HEIZMANN, Claus W

“…S100A4 is known to be involved in cancer cell motility by virtue of its ability to activate nonmuscle myosin. E-cadherin has an important role in the…”
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Duxbling Stem Cells Meet Tumorigenesis by Schäfer, Beat W.

“…Identification of tumor-initiating populations could provide insights into tumor heterogeneity and responses to treatments, but this has proven difficult in…”
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BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma by Laubscher, Dominik, Gryder, Berkley E., Sunkel, Benjamin D., Andresson, Thorkell, Wachtel, Marco, Das, Sudipto, Roschitzki, Bernd, Wolski, Witold, Wu, Xiaoli S., Chou, Hsien-Chao, Song, Young K., Wang, Chaoyu, Wei, Jun S., Wang, Meng, Wen, Xinyu, Ngo, Quy Ai, Marques, Joana G., Vakoc, Christopher R., Schäfer, Beat W., Stanton, Benjamin Z., Khan, Javed

“…Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage. The aggressive alveolar subtype is characterized by t(2;13) or t(1;13)…”
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Fenretinide induces a new form of dynamin-dependent cell death in pediatric sarcoma by Brack, Eva, Wachtel, Marco, Wolf, Anja, Kaech, Andres, Ziegler, Urs, Schäfer, Beat W.

“…Alveolar rhabdomyosarcoma (aRMS) is a highly malicious childhood malignancy characterized by specific chromosomal translocations mostly encoding the oncogenic…”
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Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity by Manzella, Gabriele, Schreck, Leonie D., Breunis, Willemijn B., Molenaar, Jan, Merks, Hans, Barr, Frederic G., Sun, Wenyue, Römmele, Michaela, Zhang, Luduo, Tchinda, Joelle, Ngo, Quy A., Bode, Peter, Delattre, Olivier, Surdez, Didier, Rekhi, Bharat, Niggli, Felix K., Schäfer, Beat W., Wachtel, Marco

“…Cancer therapy is currently shifting from broadly used cytotoxic drugs to patient-specific precision therapies. Druggable driver oncogenes, identified by…”
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A combinatorial drug screen in PDX-derived primary rhabdomyosarcoma cells identifies the NOXA - BCL-XL/MCL-1 balance as target for re-sensitization to first-line therapy in recurrent tumors by Manzella, Gabriele, Moonamale, Devmini C., Römmele, Michaela, Bode, Peter, Wachtel, Marco, Schäfer, Beat W.

“…First-line therapy for most pediatric sarcoma is based on chemotherapy in combination with radiotherapy and surgery. A significant number of patients…”
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Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene by EL NAAMAN, Christina, GRUM-SCHWENSEN, Birgitte, AMBARTSUMIAN, Noona, MANSOURI, Ahmed, GRIGORIAN, Mariam, SANTONI-RUGIU, Eric, HANSEN, Thomas, KRIAJEVSKA, Marina, SCHAFER, Beat W, W. HEIZMANN, Claus, LUKANIDIN, Eugene

“…Metastasis-promoting Mts1(S100A4) protein belongs to the S100 family of Ca(2+)-binding proteins. A mouse strain with a germ-line inactivation of the S100A4…”
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