Search Results - "Schaer, J"

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins by Schaer, Dominik J., Buehler, Paul W., Alayash, Abdu I., Belcher, John D., Vercellotti, Gregory M.

“…Hemolysis occurs in many hematologic and nonhematologic diseases. Extracellular hemoglobin (Hb) has been found to trigger specific pathophysiologies that are…”
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Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq by Marthandan, S, Baumgart, M, Priebe, S, Groth, M, Schaer, J, Kaether, C, Guthke, R, Cellerino, A, Platzer, M, Diekmann, S, Hemmerich, P

“…Cellular senescence correlates with changes in the transcriptome. To obtain a complete view on senescence-associated transcription networks and pathways, we…”
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Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development by Schaer, Dominik J, Vinchi, Francesca, Ingoglia, Giada, Tolosano, Emanuela, Buehler, Paul W

“…Hemolysis, which occurs in many disease states, can trigger a diverse pathophysiologic cascade that is related to the specific biochemical activities of free…”
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From central Atlantic continental rift to Neogene uplift - western Anti-Atlas (Morocco) by Ruiz, G. M. H., Sebti, S., Negro, F., Saddiqi, O., Frizon de Lamotte, D., Stockli, D., Foeken, J., Stuart, F., Barbarand, J., Schaer, J.-P.

“…Terra Nova, 23, 35–41, 2011 To put constraints on the Mesozoic to recent growth of the Anti‐Atlas system, we investigated the temperature–time history of rocks…”
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Activating Transcription Factor 1 Directs Mhem Atheroprotective Macrophages Through Coordinated Iron Handling and Foam Cell Protection by Boyle, Joseph J, Johns, Michael, Kampfer, Theresa, Nguyen, Aivi T, Game, Laurence, Schaer, Dominik J, Mason, Justin C, Haskard, Dorian O

“…RATIONALE:Intraplaque hemorrhage (IPH) drives atherosclerosis through the dual metabolic stresses of cholesterol-enriched erythrocyte membranes and pro-oxidant…”
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Wnt5A/CaMKII Signaling Contributes to the Inflammatory Response of Macrophages and Is a Target for the Antiinflammatory Action of Activated Protein C and Interleukin-10 by Pereira, Claudia, Schaer, Dominik J, Bachli, Esther B, Kurrer, Michael O, Schoedon, Gabriele

“…OBJECTIVE—Sepsis is a major cause of death for intensive care patients. High concentrations of inflammatory cytokines are characteristic of severe systemic…”
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Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design by Buehler, Paul W, D’Agnillo, Felice, Schaer, Dominik J

“…Hemoglobin-based oxygen carriers (HBOCs) have been developed to support blood oxygen transport capacity during hemorrhagic shock, hemolysis and ischemic…”
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Clinical outcomes in patients with systemic lupus erythematosus treated with belimumab in clinical practice settings: a retrospective analysis of results from the OBSErve study in Switzerland by von Kempis, Johannes, Duetsch, Sabine, Reuschling, Nicola, Villiger, Rahel, Villiger, Peter M, Vallelian, Florence, Schaer, Dominik J, Mueller, Ruediger B

“…To describe patterns of systemic lupus erythematosus (SLE) care and the clinical effectiveness of belimumab plus standard of care therapy in a real-world…”
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Human Plasma and Recombinant Hemopexins: Heme Binding Revisited by Karnaukhova, Elena, Owczarek, Catherine, Schmidt, Peter, Schaer, Dominik J, Buehler, Paul W

“…Plasma hemopexin (HPX) is the key antioxidant protein of the endogenous clearance pathway that limits the deleterious effects of heme released from hemoglobin…”
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Molecular detection of Trypanosoma spp. and Hepatocystis parasite infections of bats in Northern Nigeria by Kamani, J., Atuman, Y. J., Oche, D. A., Shekaro, A., Werb, O., Ejotre, I., Schaer, J.

“…Bats are mammalian hosts to a large diversity of eukaryotic protozoan blood parasites, including different genera of haemosporidians and diverse species of…”
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Constitutive Endocytosis of CD163 Mediates Hemoglobin-Heme Uptake and Determines the Noninflammatory and Protective Transcriptional Response of Macrophages to Hemoglobin by Schaer, Christian A, Schoedon, Gabriele, Imhof, Alexander, Kurrer, Michael O, Schaer, Dominik J

“…Heme toxicity contributes to the pathogenesis of chronic inflammatory diseases, atherosclerosis, and hemolysis associated vasculopathy. Macrophage clearance of…”
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Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies by Schaer, Dominik J, Buehler, Paul W

“…Hemoglobin (Hb) has multiple pathophysiologic effects when released into the intravascular space during hemolysis. The extracellular effects of Hb have…”
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MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage by Akeret, Kevin, Buzzi, Raphael M, Thomson, Bart R, Schwendinger, Nina, Klohs, Jan, Schulthess-Lutz, Nadja, Baselgia, Livio, Hansen, Kerstin, Regli, Luca, Vallelian, Florence, Hugelshofer, Michael, Schaer, Dominik J

“…The functional neurological outcome of patients with intracerebral hemorrhage (ICH) strongly relates to the degree of secondary brain injury (ICH-SBI) evolving…”
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Survey of Hepatocystis parasites of fruit bats in the Amurum forest reserve, Nigeria, identifies first host record for Rousettus aegyptiacus by Atama, N, Manu, S, Ivande, S, Rosskopf, S P, Matuschewski, K, Schaer, J

“…Parasites of the genus Hepatocystis are close relatives of Plasmodium that frequently infect epauletted fruit bats across West and East Africa. Our…”
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CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin by Schaer, Dominik J., Schaer, Christian A., Buehler, Paul W., Boykins, Robert A., Schoedon, Gabriele, Alayash, Abdu I., Schaffner, Andreas

“…CD163 mediates the internalization of hemoglobin-haptoglobin (Hb-Hp) complexes by macrophages. Because Hp binding capacity is exhausted during severe…”
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C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury by Akeret, Kevin, Thomson, Bart R., Ghosh, Subhajit, Nolte, Marc, Fischer, Urs, Humar, Rok, Regli, Luca, Schaer, Dominik J., Hugelshofer, Michael, Buzzi, Raphael M.

“…Background Preclinical studies indicate that the systemic application of C1-inhibitor, clinically used to treat hereditary angioedema, reduces secondary brain…”
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Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification by Buehler, Paul W., Abraham, Bindu, Vallelian, Florence, Linnemayr, Charlotte, Pereira, Claudia P., Cipollo, John F., Jia, Yiping, Mikolajczyk, Malgorzata, Boretti, Felicitas S., Schoedon, Gabriele, Alayash, Abdu I., Schaer, Dominik J.

“…Detoxification and clearance of extracellular hemoglobin (Hb) have been attributed to its removal by the CD163 scavenger receptor pathway. However, even…”
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Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs by Boretti, Felicitas S, Buehler, Paul W, D'Agnillo, Felice, Kluge, Katharina, Glaus, Tony, Butt, Omer I, Jia, Yiping, Goede, Jeroen, Pereira, Claudia P, Maggiorini, Marco, Schoedon, Gabriele, Alayash, Abdu I, Schaer, Dominik J

“…Release of hemoglobin (Hb) into the circulation is a central pathophysiologic event that contributes to morbidity and mortality in chronic hemolytic anemias…”
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Molecular detection of trypanosomes of the Trypanosoma livingstonei species group in diverse bat species in Central Cameroon by Tsague, K. J. A., Bakwo Fils, E. M., Atagana, J. P., Mbeng, D. W., Palm, L., Tchuinkam, T., Schaer, J.

“…Bats are hosts for diverse Trypanosoma species, including trypanosomes of the Trypanosoma cruzi clade. This clade is believed to have originated in Africa and…”
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Hepatocystis and Nycteria (Haemosporida) parasite infections of bats in the Central Region of Cameroon by Tsague, K. J. A., Bakwo Fils, E. M., Atagana, J. P., Dongue, N. V., Mbeng, D. W., Schaer, J., Tchuinkam, T.

“…Mammalian haemosporidian parasites are classified in ten genera, including Plasmodium, Hepatocystis and Nycteria. A high diversity of haemosporidian parasites…”
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