Search Results - "Schaeffer, Francis"

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1 by Biondi, Ricardo M, Hindie, Valerie, Stroba, Adriana, Zhang, Hua, Lopez-Garcia, Laura A, Idrissova, Leila, Zeuzem, Stefan, Hirschberg, Daniel, Schaeffer, Francis, Jørgensen, Thomas J D, Engel, Matthias, Alzari, Pedro M

“…Protein phosphorylation transduces a large set of intracellular signals. One mechanism by which phosphorylation mediates signal transduction is by prompting…”
Get full text

Molecular Recognition and Interfacial Catalysis by the Essential Phosphatidylinositol Mannosyltransferase PimA from Mycobacteria by Guerin, Marcelo E., Kordulakova, Jana, Schaeffer, Francis, Svetlikova, Zuzana, Buschiazzo, Alejandro, Giganti, David, Gicquel, Brigitte, Mikusova, Katarina, Jackson, Mary, Alzari, Pedro M.

“…Mycobacterial phosphatidylinositol mannosides (PIMs) and metabolically derived cell wall lipoglycans play important roles in host-pathogen interactions, but…”
Get full text

Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus by Albanesi, Daniela, Reh, Georgina, Guerin, Marcelo E, Schaeffer, Francis, Debarbouille, Michel, Buschiazzo, Alejandro, Schujman, Gustavo E, de Mendoza, Diego, Alzari, Pedro M

“…The biosynthesis of membrane lipids is an essential pathway for virtually all bacteria. Despite its potential importance for the development of novel…”
Get full text

Structural basis of lipid biosynthesis regulation in Gram-positive bacteria by Schujman, Gustavo E, Guerin, Marcelo, Buschiazzo, Alejandro, Schaeffer, Francis, Llarrull, Leticia I, Reh, Georgina, Vila, Alejandro J, Alzari, Pedro M, de Mendoza, Diego

“…Malonyl‐CoA is an essential intermediate in fatty acid synthesis in all living cells. Here we demonstrate a new role for this molecule as a global regulator of…”
Get full text

Remodeling a DNA-binding protein as a specific in vivo inhibitor of bacterial secretin PulD by Mouratou, Barbara, Schaeffer, Francis, Guilvout, Ingrid, Tello-Manigne, Diana, Pugsley, Anthony P, Alzari, Pedro M, Pecorari, Frédéric

“…We engineered a class of proteins that binds selected polypeptides with high specificity and affinity. Use of the protein scaffold of Sac7d, belonging to a…”
Get full text

Structural Plasticity and Distinct Drug-Binding Modes of LfrR, a Mycobacterial Efflux Pump Regulator by BELLINZONI, Marco, BURONI, Silvia, SCHAEFFER, Francis, RICCARDI, Giovanna, DE ROSSI, Edda, ALZARI, Pedro M

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Structural and Binding Studies of the Three-metal Center in Two Mycobacterial PPM Ser/Thr Protein Phosphatases by Wehenkel, Annemarie, Bellinzoni, Marco, Schaeffer, Francis, Villarino, Andrea, Alzari, Pedro M.

“…Phospho-Ser/Thr protein phosphatases (PPs) are dinuclear metalloenzymes classed into two large families, PPP and PPM, on the basis of sequence similarity and…”
Get full text

Crystal Structure, Catalytic Mechanism, and Mitogenic Properties of Trypanosoma Cruzi Proline Racemase by Buschiazzo, Alejandro, Goytia, Maira, Schaeffer, Francis, Degrave, Wim, Shepard, William, Grégoire, Christophe, Chamond, Nathalie, Cosson, Alain, Berneman, Armand, Coatnoan, Nicolas, Alzari, Pedro M., Minoprio, Paola

“…Amino acid racemases catalyze the stereoinversion of the chiral Cα to produce the D-enantiomers that participate in biological processes, such as cell wall…”
Get full text

A Novel Role of Malonyl-ACP in Lipid Homeostasis by Martinez, Mariano A, Zaballa, María-Eugenia, Schaeffer, Francis, Bellinzoni, Marco, Albanesi, Daniela, Schujman, Gustavo E, Vila, Alejandro J, Alzari, Pedro M, de Mendoza, Diego

“…The FapR protein of Bacillus subtilis has been shown to play an important role in membrane lipid homeostasis. FapR acts as a repressor of many genes involved…”
Get full text

Escape from reason: a penetrating analysis of trends in modern thought by Schaeffer, Francis A, Moreland, J. P

Get full text

Substrate-induced Conformational Changes in the Essential Peripheral Membrane-associated Mannosyltransferase PimA from Mycobacteria by Guerin, Marcelo E., Schaeffer, Francis, Chaffotte, Alain, Gest, Petra, Giganti, David, Korduláková, Jana, van der Woerd, Mark, Jackson, Mary, Alzari, Pedro M.

“…Phosphatidyl-myo-inositol mannosyltransferase A (PimA) is an essential glycosyltransferase (GT) involved in the biosynthesis of phosphatidyl-myo-inositol…”
Get full text

Calorimetric and Crystallographic Analysis of the Oligomeric Structure of Escherichia coli GMP Kinase by Hible, Guillaume, Renault, Louis, Schaeffer, Francis, Christova, Petya, Zoe Radulescu, Adriana, Evrin, Cécile, Gilles, Anne-Marie, Cherfils, Jacqueline

“…Guanosine monophosphate kinases (GMPKs), which catalyze the phosphorylation of GMP and dGMP to their diphosphate form, have been characterized as monomeric…”
Get full text

Inhibition of Prothrombinase by Human Secretory Phospholipase A2 Involves Binding to Factor Xa by Mounier, Carine M., Hackeng, Tilman M., Schaeffer, Francis, Faure, Grazyna, Bon, Cassian, Griffin, John H.

“…Human group II secretory phospholipase A2 (hsPLA2) exhibits significant anticoagulant activity that does not require its enzymatic activity. We examined which…”
Get full text

Pseudo-native Motifs in the Noncovalent Heme-Apocytochrome c Complex by Goldberg, Michel E., Schaeffer, Francis, Guillou, Yvonne, Djavadi-Ohaniance, Lisa

“…When beef heart apocytochrome c is unfolded, it folds upon noncovalent heme binding (Dumont, M. E., Corin, A. F., and Campbell, G.A. (1994) Biochemistry, 33,…”
Get full text

3,5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure―Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds by STROBA, Adriana, SCHAEFFER, Francis, HINDIE, Valerie, LOPEZ-GARCIA, Laura, ADRIAN, Iris, FRÖHNER, Wolfgang, HARTMANN, Rolf W, BIONDI, Ricardo M, ENGEL, Matthias

“…The modulation of protein kinase activities by low molecular weight compounds is a major goal of current pharmaceutical developments. In this line, important…”
Get full text

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds by Engel, Matthias, Hindie, Valerie, Lopez-Garcia, Laura A, Stroba, Adriana, Schaeffer, Francis, Adrian, Iris, Imig, Jochen, Idrissova, Leila, Nastainczyk, Wolfgang, Zeuzem, Stefan, Alzari, Pedro M, Hartmann, Rolf W, Piiper, Albrecht, Biondi, Ricardo M

“…Organisms rely heavily on protein phosphorylation to transduce intracellular signals. The phosphorylation of a protein often induces conformational changes,…”
Get full text

Substrate-induced Conformational Changes in the Essential Peripheral Membrane-associated Mannosyltransferase PimA from Mycobacteria: IMPLICATIONS FOR CATALYSIS by Guerin, Marcelo E, Schaeffer, Francis, Chaffotte, Alain, Gest, Petra, Giganti, David, Korduláková, Jana, van der Woerd, Mark, Jackson, Mary, Alzari, Pedro M

“…Phosphatidyl-myo-inositol mannosyltransferase A (PimA) is an essential glycosyltransferase (GT) involved in the biosynthesis of phosphatidyl-myo-inositol…”
Get full text

Art and the Bible by Schaeffer, Francis A

“…In this book's classic essays, Francis A. Schaeffer first examines the scriptural record of the use of various art forms, and then establishes a Christian…”
Get full text

Mechanistic Insights into the Retaining Glucosyl-3-phosphoglycerate Synthase from Mycobacteria by Urresti, Saioa, Albesa-Jové, David, Schaeffer, Francis, Pham, Ha T., Kaur, Devinder, Gest, Petra, van der Woerd, Mark J., Carreras-González, Ana, López-Fernández, Sonia, Alzari, Pedro M., Brennan, Patrick J., Jackson, Mary, Guerin, Marcelo E.

“…Considerable progress has been made in recent years in our understanding of the structural basis of glycosyl transfer. Yet the nature and relevance of the…”
Get full text

Escape from Reason by Schaeffer, Francis A, Moreland, J. P

“…Truth is no longer based on reason. What we feel is now the truest reality. Yet despite our obsession with the emotive and the experiential, we still face…”
Get full text