Search Results - "Schaefer, Saul"

Will DANCAVAS be the most important screening trial in the last 50 years? by Dixit, Neal M., Chau, Edward, Schaefer, Saul

“…Screening trials for cardiovascular disease have not demonstrated a reduction in all-cause mortality. The Danish Cardiovascular Screening trial (DANCAVAS)…”
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Ketone Ester D-β-Hydroxybutyrate-(R)-1,3 Butanediol Prevents Decline in Cardiac Function in Type 2 Diabetic Mice by Thai, Phung N, Miller, Charles V, King, M Todd, Schaefer, Saul, Veech, Richard L, Chiamvimonvat, Nipavan, Bers, Donald M, Dedkova, Elena N

“…Background Heart failure is responsible for approximately 65% of deaths in patients with type 2 diabetes mellitus. However, existing therapeutics for type 2…”
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Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides by Thai, Phung N, Seidlmayer, Lea K, Miller, Charles, Ferrero, Maura, Dorn, II, Gerald W, Schaefer, Saul, Bers, Donald M, Dedkova, Elena N

“…Aging and heart failure (HF) are each characterized by increased mitochondrial damage, which may contribute to further cardiac dysfunction. Mitophagy in…”
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Age-Adjusted D-Dimer in the Prediction of Pulmonary Embolism: Does a Normal Age-Adjusted D-Dimer Rule Out PE? by Ortiz, Jacob, Saeed, Rabia, Little, Christopher, Schaefer, Saul

“…Risk assessment for pulmonary embolism (PE) currently relies on physician judgment, clinical decision rules (CDR), and D-dimer testing. There is still…”
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Nicotinic Acid is a Common Regulator of Heat-Sensing TRPV1-4 Ion Channels by Ma, Linlin, Lee, Bo Hyun, Clifton, Heather, Schaefer, Saul, Zheng, Jie

“…Nicotinic acid (NA, a.k.a. vitamin B3 or niacin) can reduce blood cholesterol and low-density lipoproteins whereas increase high-density lipoproteins. However,…”
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Beta-adrenergic antagonist for the healing of chronic diabetic foot ulcers: study protocol for a prospective, randomized, double-blinded, controlled and parallel-group study by Kaur, Ramanjot, Tchanque-Fossuo, Catherine, West, Kaitlyn, Hadian, Yasmin, Gallegos, Anthony, Yoon, Daniel, Ismailyan, Ligia, Schaefer, Saul, Dahle, Sara E, Isseroff, R Rivkah

“…Diabetic foot ulcers (DFUs) are the most common cause of leg amputations and their management is extremely challenging. Despite many advances and expensive…”
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PK11195 Protects From Cell Death Only When Applied During Reperfusion: Succinate-Mediated Mechanism of Action by Seidlmayer, Lea K., Hanson, Benjamin J., Thai, Phung N., Schaefer, Saul, Bers, Donald M., Dedkova, Elena N.

“…Aim : Reperfusion after myocardial ischemia causes cellular injury, in part due to changes in mitochondrial Ca 2+ handling, oxidative stress, and myocyte…”
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Phosphorylation of ARC Is a Critical Element in the Antiapoptotic Effect of Anesthetic Preconditioning by Lu, Xiyuan, Moore, Peter G., Liu, Hong, Schaefer, Saul

“…Transient exposure to volatile anesthetics before cardiac ischemia/reperfusion (I/R), termed anesthetic preconditioning, limits myocardial injury and inhibits…”
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Recovery of methamphetamine associated cardiomyopathy predicted by late gadolinium enhanced cardiovascular magnetic resonance by Lopez, Javier E, Yeo, Khung, Caputo, Gary, Buonocore, Michael, Schaefer, Saul

“…Methamphetamine is known to cause a cardiomyopathy which may be reversible with appropriate medical therapy and cessation of use. Late gadolinium enhancement…”
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Marked elevation of B-type natriuretic peptide in patients with heart failure and preserved ejection fraction by Samuel, Tate, Andrea, Griem, Blythe, Durbin-Johnson, Clifton, Watt, Saul, Schaefer

“…Marked elevations of B-type natriuretic peptide （BNP） are not generally seen in patients with heart failure and preserved ejection fraction （HFpEF）. The…”
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NADH Oxidase Activity of Rat Cardiac Sarcoplasmic Reticulum Regulates Calcium-Induced Calcium Release by Cherednichenko, Gennady, Zima, Aleksey V, Feng, Wei, Schaefer, Saul, Blatter, Lothar A, Pessah, Isaac N

“…ABSTRACT—NADH and Ca have important regulatory functions in cardiomyocytes related to excitation-contraction coupling and ATP production. To elucidate elements…”
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A REVERSIBLE CAUSE OF ATRIAL TACHYCARDIA: A LOW HANGING PORT by Bernstein, Hannah M., Schaefer, Saul

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Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury by RAMASAMY, R, OATES, P. J, SCHAEFER, S

“…Diabetes increases the incidence of cardiovascular disease as well as the complications of myocardial infarction. Studies using animal models of diabetes have…”
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Review: In older patients without CVD, statins reduce Ml and stroke but not all-cause mortality by Schaefer, Saul

“…Schaefer comments on a study by Savarese et al examining whether statins reduce all-cause mortality and CV events. In older patients without cardiovascular…”
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Metabolic effects of aldose reductase inhibition during low-flow ischemia and reperfusion by Ramasamy, R, Trueblood, N, Schaefer, S

“…Several studies have shown that maintenance of glycolysis limits the metabolic and functional consequences of low-flow ischemia. Because diabetic animals are…”
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Review: In older patients without CVD, statins reduce MI and stroke but not all-cause mortality by Schaefer, Saul

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Chelerythrine increases Na-K-ATPase activity and limits ischemic injury in isolated rat hearts by Lundmark, J L, Ramasamy, R, Vulliet, P R, Schaefer, S

“…Myocardial ischemia results in an increase in intracellular sodium concentration ([Na]i), which may lead to cellular injury via cellular swelling and calcium…”
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Mitochondrial Translocator Protein (TSPO) Prevents Heart Failure by Increasing Cardiac Utilization of Fatty Acids by Thai, Phung, Herren, Anthony W., Ren, Lu, Bers, Donald M., Schaefer, Saul, Dedkova, Elena N.

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ACP Journal Club. Review: in older patients without CVD, statins reduce MI and stroke but not all-cause mortality by Schaefer, Saul

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Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure by Thai, Phung N., Daugherty, Daniel J., Frederich, Bert J., Lu, Xiyuan, Deng, Wenbin, Bers, Donald M., Dedkova, Elena N., Schaefer, Saul

“…Heart failure (HF) is characterized by abnormal mitochondrial calcium (Ca 2+ ) handling, energy failure and impaired mitophagy resulting in contractile…”
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