Search Results - "Schaefer, K L"

Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling by Garofalo, C, Manara, M C, Nicoletti, G, Marino, M T, Lollini, P-L, Astolfi, A, Pandini, G, López-Guerrero, J A, Schaefer, K-L, Belfiore, A, Picci, P, Scotlandi, K

“…Identification of patient selection criteria and understanding of the potential mechanisms involved in the development of resistance are crucial for an…”
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Hsa-mir-145 is the top EWS-FLI1-repressed microRNA involved in a positive feedback loop in Ewing's sarcoma by Ban, J, Jug, G, Mestdagh, P, Schwentner, R, Kauer, M, Aryee, D N T, Schaefer, K-L, Nakatani, F, Scotlandi, K, Reiter, M, Strunk, D, Speleman, F, Vandesompele, J, Kovar, H

“…EWS-FLI1 is a chromosome translocation-derived chimeric transcription factor that has a central and rate-limiting role in the pathogenesis of Ewing's sarcoma…”
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1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma by Mackintosh, C, Ordóñez, J L, García-Domínguez, D J, Sevillano, V, Llombart-Bosch, A, Szuhai, K, Scotlandi, K, Alberghini, M, Sciot, R, Sinnaeve, F, Hogendoorn, P C W, Picci, P, Knuutila, S, Dirksen, U, Debiec-Rychter, M, Schaefer, K-L, de Álava, E

“…Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to…”
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Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway by Lu, R, Wu, S, Zhang, Y-g, Xia, Y, Liu, X, Zheng, Y, Chen, H, Schaefer, K L, Zhou, Z, Bissonnette, M, Li, L, Sun, J

“…Salmonella infections can become chronic and increase the risk of cancer. The mechanisms by which specific Salmonella organisms contribute to cancer, however,…”
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High STEAP1 expression is associated with improved outcome of Ewing's sarcoma patients by Grunewald, T.G.P., Ranft, A., Esposito, I., da Silva-Buttkus, P., Aichler, M., Baumhoer, D., Schaefer, K.L., Ottaviano, L., Poremba, C., Jundt, G., Jürgens, H., Dirksen, U., Richter, G.H.S., Burdach, S.

“…Ewing's sarcoma (ES) is the second most common bone or soft-tissue sarcoma in childhood and adolescence and features a high propensity to metastasize. The…”
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Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells by KREPPEL, M, ARYEE, D. N. T, SCHAEFER, K.-L, AMANN, G, KOFLER, R, POREMBA, C, KOVAR, H

“…High CD99 expression levels and rearrangements of the EWS gene with ETS transcription factor genes characterize the Ewing's sarcoma family of tumors (ESFT)…”
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Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas by SCHEEL, Christina, SCHAEFER, Karl-Ludwig, JAUCH, Anna, KELLER, Monika, WAI, Daniel, BRINKSCHMIDT, Christian, VAN VALEN, Frans, BOECKER, Werner, DOCKHORN-DWORNICZAK, Barbara, POREMBA, Christopher

“…Telomere maintenance is regarded as a key mechanism in overcoming cellular senescence in tumor cells and in most cases is achieved by the activation of…”
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Microsatellite instability in ewing tumor is not associated with loss of mismatch repair protein expression by ALLDINGER, I, SCHAEFER, K. L, GOEDDE, D, OTTAVIANO, L, DIRKSEN, U, RANFT, A, JUERGENS, H, GABBERT, H. E, KNOEFEL, W. T, POREMBA, C

“…Only few clinical factors predict the prognosis of patients with Ewing tumors. Unfavorable outcome is associated with primary metastatic disease, age > 15…”
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Population-based genetic alterations in Ewing’s tumors from Japanese and European Caucasian patients by Ozaki, T., Schaefer, K.-L., Wai, D., Yokoyama, R., Ahrens, S., Diallo, R., Hasegawa, T., Shimoda, T., Hirohashi, S., Kawai, A., Naito, N., Morimoto, Y., Inoue, H., Boecker, W., Juergens, H., Winkelmann, W., Dockhorn-Dworniczak, B., Poremba, C.

“…Background: The incidence of Ewing’s tumors (ETs) is lower in Asians or African-Americans than in Caucasians. Patients and methods: Japanese ETs were available…”
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The melanocyte inducing factor MITF is stably expressed in cell lines from human clear cell sarcoma by LI, K. K. C, GOODALL, J, LEE, K. A. W, CODING, C. R, LIAO, S-K, WANG, C-H, LIN, Y-C, HIRAGA, H, NOJIMA, T, NAGASHIMA, K, SCHAEFER, K-L

“…Clear cell sarcoma (CCS) is associated with the EWS/ATF1 oncogene that is created by chromosomal fusion of the Ewings Sarcoma oncogene (EWS) and the cellular…”
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Telomerase Activity and Telomerase Subunits Gene Expression Patterns in Neuroblastoma: A Molecular and Immunohistochemical Study Establishing Prognostic Tools for Fresh-Frozen and Paraffin-Embedded Tissues by POREMBA, C, SCHEEL, C, HERO, B, CHRISTIANSEN, H, SCHAEFER, K.-L, NAKAYAMA, J.-I, BERTHOLD, F, JUERGENS, H, BOECKER, W, DOCKHORN-DWORNICZAK, B

“…We have recently demonstrated that telomerase activity (TA) is an independent prognostic factor in neuroblastomas. In the present study, the prognostic impact…”
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Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1 IGF-1R signalling and reveals TOPK as a new target by Herrero-Martín, D, Osuna, D, Ordóñez, J L, Sevillano, V, Martins, A S, Mackintosh, C, Campos, M, Madoz-Gúrpide, J, Otero-Motta, A P, Caballero, G, Amaral, A T, Wai, D H, Braun, Y, Eisenacher, M, Schaefer, K-L, Poremba, C, de Alava, E

“…BACKGROUND : Ewing sarcoma is a paradigm of solid tumour -bearing chromosomal translocations resulting in fusion proteins that act as deregulated transcription…”
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Genetic imbalances revealed by comparative genomic hybridization in Ewing tumors by Ozaki, Toshifumi, Paulussen, Michael, Poremba, Christopher, Brinkschmidt, Christian, Rerin, Julio, Ahrens, Susanne, Hoffmann, Christiane, Hillmann, Axel, Wai, Daniel, Schaefer, Karl-Ludwig, Boecker, Werner, Juergens, Heribert, Winkelmann, Winfried, Dockhorn-Dworniczak, Barbara

“…Ewing tumors are characterized by reciprocal translocations involving the EWS gene on 22q12 fused to ETS transcription‐factor family members. Little is known…”
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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase by KOEPP, Deanna M, SCHAEFER, Laura K, XIN YE, KEYOMARSI, Khandan, CHU, Claire, HARPER, J. Wade, ELLEDGE, Stephen J

“…Cyclin E binds and activates the cyclin-dependent kinase Cdk2 and catalyzes the transition from the G1 phase to the S phase of the cell cycle. The amount of…”
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Traditional and emerging molecular markers in neuroblastoma prognosis: the good, the bad and the ugly by Poremba, C, Hero, B, Goertz, H G, Scheel, C, Wai, D, Schaefer, K L, Christiansen, H, Berthold, F, Juergens, H, Boecker, W, Dockhorn-Dworniczak, B

“…Neuroblastomas (NB) are a heterogeneous group of childhood tumours with a wide range of likelihood for tumour progression. As traditional parameters do not…”
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Genetic imbalances in benign bone tumors revealed by comparative genomic hybridization by Ozaki, T, Wai, D, Schaefer, K-L, Goshager, G, Boecker, W, Dockhorn-Dworniczak, B, Poremba, Ch

“…There have been no reports on choromosomal aberrations of benign bone tumors revealed by comparative genomic hybridization (CGH). CGH analysis of benign tumors…”
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EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin by SILIGAN, Christine, BAN, Jozef, BACHMAIER, Radostina, SPAHN, Laura, KREPPEL, Michael, SCHAEFER, Karl-Ludwig, POREMBA, Christopher, ARYEE, Dave N. T, KOVAR, Heinrich

“…In all, 85% of Ewing's sarcoma family tumors (ESFT), a neoplasm of unknown histogenesis, express EWS-FLI1 transcription factor gene fusions. To characterize…”
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Angiotensin II receptor antagonists: the prototype losartan by Schaefer, K L, Porter, J A

“…To describe a new class of antihypertensive agents, the angiotensin II receptor antagonists, with emphasis on the prototype losartan. Pharmacokinetic data and…”
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Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3 by SCHAEFER, Karl-Ludwig, BRACHWITZ, Kristin, SELLE, Barbara, SPAHN, Laura, LIAO, Shuen-Kuei, LEE, Kevin A. W, HOGENDOORN, Pancras C. W, REIFENBERGER, Guido, GABBERT, Helmut E, POREMBA, Christopher, WAI, Daniel H, BRAUN, Yvonne, DIALLO, Raihanatou, KORSCHING, Eberhard, EISENACHER, Martin, VOSS, Reinhard, VAN VALEN, Frans, BAER, Claudia

“…Clear cell sarcoma of soft tissue (CCSST), also known as malignant melanoma of soft parts, represents a rare lesion of the musculoskeletal system usually…”
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Monoclonality in normal epithelium and in hyperplastic and neoplastic lesions of the breast by Diallo, Raihanatou, Schaefer, Karl-Ludwig, Poremba, Christopher, Shivazi, Nazli, Willmann, Vivian, Buerger, Horst, Dockhorn-Dworniczak, Barbara, Boecker, Werner

“…The clonal nature of neoplastic lesions such as invasive breast cancer and ductal carcinoma in situ (DCIS) has been widely proven by several proliferative,…”
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