Search Results - "Schaeck, John"

M281, an anti-FcRn antibody, inhibits IgG transfer in a human ex vivo placental perfusion model by Roy, Sucharita, Nanovskaya, Tatiana, Patrikeeva, Svetlana, Cochran, Edward, Parge, Viraj, Guess, Jamey, Schaeck, John, Choudhury, Amit, Ahmed, Mahmoud, Ling, Leona E.

“…The transfer of pathogenic immunoglobulin G antibodies from mother to fetus is a critical step in the pathophysiology of alloimmune and autoimmune diseases of…”
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Engineered IgG1-Fc Molecules Define Valency Control of Cell Surface Fcγ Receptor Inhibition and Activation in Endosomes by Bailey, Elizabeth M, Choudhury, Amit, Vuppula, Harika, Ortiz, Daniel F, Schaeck, John, Manning, Anthony M, Bosques, Carlos J, Hoppe, Adam D

“…The inhibition of Fcγ receptors (FcγR) is an attractive strategy for treating diseases driven by IgG immune complexes (IC). Previously, we demonstrated that an…”
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High-resolution physicochemical characterization of different intravenous immunoglobulin products by Washburn, Nathaniel, Meccariello, Robin, Hu, Shaohui, Hains, Maurice, Bhatnagar, Naveen, Sarvaiya, Hetal, Kapoor, Bulbul, Schaeck, John, Pino, Ignacio, Manning, Anthony, Lansing, Jonathan C, Bosques, Carlos J

“…Intravenous immunoglobulin (IVIg) is a complex mixture drug comprising diverse immunoglobulins and non-IgG proteins purified from the plasma of thousands of…”
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Inhibitory Fc-Gamma IIb Receptor Signaling Induced by Multivalent IgG-Fc Is Dependent on Sialylation by Beneduce, Christopher, Nguyen, Stephanie, Washburn, Nathaniel, Schaeck, John, Meccariello, Robin, Holte, Kimberly, Ortiz, Daniel, Manning, Anthony M., Bosques, Carlos J., Kurtagic, Elma

“…Immunoglobulin (IgG) Fc glycosylation has been shown to be important for the biological activity of antibodies. Fc sialylation is important for the…”
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Rapid Cage Degradation of 1-Formyl- and 1-Alkyloxycarbonyl-Substituted 1,2-Dicarba-closo-dodecaboranes by Water or Methanol in Polar Organic Solvents by Schaeck, John J, Kahl, Stephen B

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Improved Methods for the Synthesis of Porphyrin Alcohols and Aldehydes from Protoporphyrin IX Dimethyl Ester and Their Further Modification by Kahl, Stephen B, Schaeck, John J, Koo, Myoung-Seo

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32: M281, an anti-FcRn antibody, inhibits IgG transfer in a human ex-vivo placental perfusion model by Ling, Leona, Roy, Sucharita, Nanovskaya, Tatiana, Patrikeeva, Svetlana, Cochran, Edward, Parge, Viraj, Schaeck, John J., Ahmed, Mahmoud S.

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Characterization of heparin–protein interaction by saturation transfer difference (STD) NMR by Yu, Fei, Roy, Sucharita, Arevalo, Enrique, Schaeck, John, Wang, Jason, Holte, Kimberly, Duffner, Jay, Gunay, Nur Sibel, Capila, Ishan, Kaundinya, Ganesh V.

“…The binding affinity and specificity of heparin to proteins is widely recognized to be sulfation-pattern dependent. However, for the majority of…”
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Abstract 3244: Improved Fc-mediated effector functions by an anti-CTLA-4 multivalent Fc agent by Rutitzky, Laura, Ortiz, Daniel F., Lansing, Jonathan C., Brown, Julia, Paquette, Joseph, Garofalo, Kevin, D'Alessandro, Josephine, Bhatnagar, Naveen, Hains, Maurice, Gupta, Abhinav, Lee, Stan, Zouaoui, Radouane, Wang, Jason, Schaeck, John, Marchese, Salvatore, Meccariello, Robin, Washburn, Nathaniel, Holte, Kimberly, Bosques, Carlos J., Manning, Anthony M.

“…Numerous therapeutic monoclonal antibodies (mAbs) rely on antibody-dependent cell cytotoxicity (ADCC), antibody-dependent cell phagocytosis (ADCP) and…”
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Identification of a Novel Structure in Heparin Generated by Sequential Oxidative–Reductive Treatment by Beccati, Daniela, Roy, Sucharita, Lech, Miroslaw, Ozug, Jennifer, Schaeck, John, Gunay, Nur S, Zouaoui, Radouane, Capila, Ishan, Kaundinya, Ganesh V

“…Unfractionated heparin is isolated from animal organs, predominantly porcine intestinal mucosa, and goes through an extensive process of purification before it…”
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M281: A Therapeutic Anti-FcRn Blocking Antibody for Rapid Clearance of IgG and IgG Autoantibodies in Immune Cytopenias and Other Auto/Allo-Immune Disease by Ling, Leona E, Roy, Sucharita, Daly, Thomas, Cochran, Edward, Tyler, Steven, Markowitz, Lynn, Bulik, Dorota, Choudhury, Amit, Meador, James, Parge, Viraj, Mekala, Divya, Sipsey, Sandra, Gurnani, Srishti, Duffner, Jay, Lee, Stan, Washburn, Nathaniel, Meccariello, Robin, Schaeck, John, Wang, Jing, Schultes, Birgit, Hillson, Jan L., Avery, William, Kaundinya, Ganesh V., Manning, Anthony M.

“…Introduction IgG antibodies are the primary pathogenic agent in a number of auto- or allo-immune diseases. Efficacious therapies which decrease systemic levels…”
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The synthesis of boronated porphyrins as inhibitors of HIV-1 protease by Schaeck, John Joseph

“…Starting with a small SAR for boronated and nonboronated porphyrin inhibitors of HIV-1 protease (DeCamp, D. L.; Babe, L. M.; Salto, R.; Lucich, J. L.; Koo,…”
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