Search Results - "Schadt, E.E."

Genetic Inheritance of Gene Expression in Human Cell Lines by Monks, S.A., Leonardson, A., Zhu, H., Cundiff, P., Pietrusiak, P., Edwards, S., Phillips, J.W., Sachs, A., Schadt, E.E.

“…Combining genetic inheritance information, for both molecular profiles and complex traits, is a promising strategy not only for detecting quantitative trait…”
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An integrative genomics approach to the reconstruction of gene networks in segregating populations by Zhu, J, Lum, P Y, Lamb, J, GuhaThakurta, D, Edwards, S W, Thieringer, R, Berger, J P, Wu, M S, Thompson, J, Sachs, A B, Schadt, E E

“…The reconstruction of genetic networks in mammalian systems is one of the primary goals in biological research, especially as such reconstructions relate to…”
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Next-generation sequencing for detection of mutations associated with rare disorders in patients meeting diagnostic criteria for primary progressive multiple sclerosis by Weisfeld-Adams, J.D, Ludtke, A, Scott, S.A, Katzsand, I, Naik, H, Linderman, M.D, Paizan-Ruiz, C, Wasserstein, M.P, Shi, L, Brandt, T, McGraw, C.A, Kornreich, R, Farrell, C, Schadt, E.E, Lublin, F.D, Oksenberg, J.S

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1271P Molecular driver mutations in never-smokers with lung adenocarcinoma by Mack, P.C., Klein, M., Ayers, K., Uzilov, A., Zhou, X., Corrigan, D., Dietz, M., Fink, M., Guin, S., Kip, N.S., Rossi, M., Oh, W., Hantash, F., Newman, S., Schadt, E.E., Chen, R., Hirsch, F.

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Molecular systems evaluation of oligomerogenic [APP.sup.E693Q] and fibrillogenic [APP.sup.KM670/671NL]/[PSEN1.sup.Δexon9] mouse models identifies shared features with human Alzheimer's brain molecular pathology by Readhead, B, Haure-Mirande, J.-v, Zhang, B, Haroutunian, V, Gandy, S, Schadt, E.E, Dudley, J.T, Ehrlich, M.E

“…Identification and characterization of molecular mechanisms that connect genetic risk factors to Initiation and evolution of disease pathophysiology represent…”
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Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver by O'Brien, T R, Kohaar, I, Pfeiffer, R M, Maeder, D, Yeager, M, Schadt, E E, Prokunina-Olsson, L

“…A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3′ untranslated regions of human…”
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Genetics of gene expression surveyed in maize, mouse and man by Schadt, Eric E, Friend, Stephen H, Monks, Stephanie A, Drake, Thomas A, Lusis, Aldons J, Che, Nam, Colinayo, Veronica, Ruff, Thomas G, Milligan, Stephen B, Lamb, John R, Cavet, Guy, Linsley, Peter S, Mao, Mao, Stoughton, Roland B

“…Treating messenger RNA transcript abundances as quantitative traits and mapping gene expression quantitative trait loci for these traits has been pursued in…”
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ApoE genotyping as a progression-rate biomarker in phase II disease-modification trials for Alzheimer's disease by Stone, D J, Molony, C, Suver, C, Schadt, E E, Potter, W Z

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A new paradigm for drug discovery: integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets by Schadt, E E, Monks, S A, Friend, S H

“…Application of statistical genetics approaches to variations in mRNA transcript abundances in segregating populations can be used to identify genes and…”
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WO3-OR-4 IDENTIFICATION OF DOWNSTREAM TARGETS OF USF1 by Plaisier, C.L., van der Kallen, C., de Bruin, T.W., Schadt, E.E., Pajukanta, P.

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WO7-OR-4 IDENTIFICATION OF A GENE ON CHROMOSOME 11P REGULATING PLASMA TRIGLYCERIDE LEVELS by Kyttala, M., Plaisier, C., Aouizerat, B., de Bruin, T., Schadt, E.E., van der Kallen, C., Pajukanta, P.

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