Search Results - "Schade, Amy E"

Combating castration-resistant prostate cancer by co-targeting the epigenetic regulators EZH2 and HDAC by Schade, Amy E, Kuzmickas, Ryan, Rodriguez, Carrie L, Mattioli, Kaia, Enos, Miriam, Gardner, Alycia, Cichowski, Karen

“…While screening and early detection have reduced mortality from prostate cancer, castration-resistant disease (CRPC) is still incurable. Here, we report that…”
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Cotargeting a MYC/eIF4A-survival axis improves the efficacy of KRAS inhibitors in lung cancer by Nardi, Francesca, Perurena, Naiara, Schade, Amy E, Li, Ze-Hua, Ngo, Kenneth, Ivanova, Elena V, Saldanha, Aisha, Li, Chendi, Gokhale, Prafulla C, Hata, Aaron N, Barbie, David A, Paweletz, Cloud P, Jänne, Pasi A, Cichowski, Karen

“…Despite the success of KRAS G12C inhibitors in non-small cell lung cancer (NSCLC), more effective treatments are needed. One preclinical strategy has been to…”
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STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells by Kim, Jong Wook, Berrios, Christian, Kim, Miju, Schade, Amy E, Adelmant, Guillaume, Yeerna, Huwate, Damato, Emily, Iniguez, Amanda Balboni, Florens, Laurence, Washburn, Michael P, Stegmaier, Kim, Gray, Nathanael S, Tamayo, Pablo, Gjoerup, Ole, Marto, Jarrod A, DeCaprio, James, Hahn, William C

“…Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers, and partial loss of PP2A function contributes to cell…”
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RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation by Schade, Amy E, Fischer, Martin, DeCaprio, James A

“…Abstract Cell cycle gene expression occurs in two waves. The G1/S genes encode factors required for DNA synthesis and the G2/M genes contribute to mitosis. The…”
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Coordinating gene expression during the cell cycle by Fischer, Martin, Schade, Amy E., Branigan, Timothy B., Müller, Gerd A., DeCaprio, James A.

“…Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB):E2F and DREAM complexes, which repress all cell cycle genes during…”
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MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity by Branigan, Timothy B., Kozono, David, Schade, Amy E., Deraska, Peter, Rivas, Hembly G., Sambel, Larissa, Reavis, Hunter D., Shapiro, Geoffrey I., D’Andrea, Alan D., DeCaprio, James A.

“…To identify genes whose loss confers resistance to CHK1 inhibitors, we perform genome-wide CRISPR-Cas9 screens in non-small-cell lung cancer (NSCLC) cell lines…”
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AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution by Schade, Amy E, Perurena, Naiara, Yang, Yoona, Rodriguez, Carrie L, Krishnan, Anjana, Gardner, Alycia, Loi, Patrick, Xu, Yilin, Nguyen, Van T M, Mastellone, G M, Pilla, Natalie F, Watanabe, Marina, Ota, Keiichi, Davis, Rachel A, Mattioli, Kaia, Xiang, Dongxi, Zoeller, Jason J, Lin, Jia-Ren, Morganti, Stefania, Garrido-Castro, Ana C, Tolaney, Sara M, Li, Zhe, Barbie, David A, Sorger, Peter K, Helin, Kristian, Santagata, Sandro, Knott, Simon R V, Cichowski, Karen

“…Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and has the highest rate of recurrence . The predominant standard of care for…”
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Cyclin D–CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB by Schade, Amy E., Oser, Matthew G., Nicholson, Hilary E., DeCaprio, James A.

“…The retinoblastoma protein (RB) restricts cell cycle gene expression and entry into the cell cycle. The RB-related protein p130 forms the DREAM (DP, RB-like,…”
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Combating castration-resistant prostate cancer by co-targeting the epigenetic regulators EZH2 and HDAC by Amy E. Schade, Ryan Kuzmickas, Carrie L. Rodriguez, Kaia Mattioli, Miriam Enos, Alycia Gardner, Karen Cichowski

“…While screening and early detection have reduced mortality from prostate cancer, castration-resistant disease (CRPC) is still incurable. Here, we report that…”
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Abstract 2538: p53 activation induces cell cycle arrest by promoting DREAM and RB repression of cell cycle genes by Schade, Amy E., Fischer, Martin, DeCaprio, James A.

“…Abstract p53 activation results cell cycle arrest at the G1/S checkpoint and the repression of early (G1/S) and late (G2/M) cell cycle gene expression in a p21…”
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