Search Results - "Schaddelee, M P"

Proarrhythmic Safety of Repeat Doses of Mirabegron in Healthy Subjects: A Randomized, Double-Blind, Placebo-, and Active-Controlled Thorough QT Study by Malik, M, van Gelderen, E M, Lee, J H, Kowalski, D L, Yen, M, Goldwater, R, Mujais, S K, Schaddelee, M P, de Koning, P, Kaibara, A, Moy, S S, Keirns, J J

“…Potential effects of the selective β3‐adrenoceptor agonist mirabegron on cardiac repolarization were studied in healthy subjects. The four‐arm, parallel,…”
Get full text

Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists by Schaddelee, M P, Groenendaal, D, DeJongh, J, Cleypool, C G J, IJzerman, A P, De Boer, A G, Danhof, M

“…A population pharmacokinetic model is proposed for estimation of the brain distribution clearance of synthetic A1 receptor agonists in vivo. Rats with…”
Get more information

Purines in Portugal by Stone, Trevor W, Zimmermann, Herbert, Lopes, Luisa V, Schaddelee, Marloes P

“…The 2001 FENS Summer School was held on the general topic of Purines and Neuronal Communication, with the subtitle, Implications for Neuroprotection and Pain…”
Get full text

Functional role of adenosine receptor subtypes in the regulation of blood–brain barrier permeability: possible implications for the design of synthetic adenosine derivatives by Schaddelee, Marloes P., Voorwinden, Heleen L., van Tilburg, Erica W., Pateman, Tony J., Ijzerman, Adriaan P., Danhof, Meindert, de Boer, Albertus G.

“…The objective of this investigation was to determine the functional role of adenosine receptor subtypes in the regulation of blood–brain barrier (BBB)…”
Get full text

Population pharmacokinetic–pharmacodynamic modelling of the anti-hyperalgesic effect of 5′deoxy- N 6-cylopentyladenosine in the mononeuropathic rat by Schaddelee, Marloes P., DeJongh, Joost, Collins, Sue D., de Boer, Albertus G., Ijzerman, Adriaan P., Danhof, Meindert

“…The objective of this investigation was to characterise the pharmacokinetic–pharmacodynamic correlation of 5′-deoxy- N 6-cyclopentyl-adenosine (5′dCPA) in the…”
Get full text