Search Results - "Schackert, Konrad"

Age‐dependent performance of BRAF mutation testing in Lynch syndrome diagnostics by Bläker, Hendrik, Haupt, Saskia, Morak, Monika, Holinski‐Feder, Elke, Arnold, Alexander, Horst, David, Sieber‐Frank, Julia, Seidler, Florian, Winterfeld, Moritz, Alwers, Elizabeth, Chang‐Claude, Jenny, Brenner, Hermann, Roth, Wilfried, Engel, Christoph, Löffler, Markus, Möslein, Gabriela, Schackert, Hans‐Konrad, Weitz, Jürgen, Perne, Claudia, Aretz, Stefan, Hüneburg, Robert, Schmiegel, Wolff, Vangala, Deepak, Rahner, Nils, Steinke‐Lange, Verena, Heuveline, Vincent, von Knebel Doeberitz, Magnus, Ahadova, Aysel, Hoffmeister, Michael, Kloor, Matthias

“…BRAF V600E mutations have been reported as a marker of sporadic microsatellite instability (MSI) colorectal cancer (CRC). Current international diagnostic…”
Get full text

Biallelic MLH1 SNP cDNA expression or constitutional promoter methylation can hide genomic rearrangements causing Lynch syndrome by Morak, Monika, Koehler, Udo, Schackert, Hans Konrad, Steinke, Verena, Royer-Pokora, Brigitte, Schulmann, Karsten, Kloor, Matthias, Höchter, Wilhelm, Weingart, Josef, Keiling, Cortina, Massdorf, Trisari, Holinski-Feder, Elke

“…A positive family history, germline mutations in DNA mismatch repair genes, tumours with high microsatellite instability, and loss of mismatch repair protein…”
Get more information

Meta-analysis of microarray data on pancreatic cancer defines a set of commonly dysregulated genes by GRÜTZMANN, Robert, BORISS, Hinnerk, AMMERPOHL, Ole, LÜTTGES, Jutta, KALTHOFF, Holger, SCHACKERT, Hans Konrad, KLÖPPEL, Günter, SAEGER, Hans Detlev, PILARSKY, Christian

“…Pancreatic ductal adenocarcinoma is the eighth most common cancer with the lowest overall 5-year relative survival rate of any tumor type today. Expression…”
Get full text

Frequent loss of the CDKN2C (p18INK4c) gene product in pituitary adenomas by Kirsch, Matthias, Mörz, Michael, Pinzer, Thomas, Schackert, Hans Konrad, Schackert, Gabriele

“…Genomic alterations of cyclin‐dependent kinase inhibitors have been demonstrated in a variety of tumor types including brain tumors. Among them, the…”
Get full text

Gene Expression Profiling of Microdissected Pancreatic Ductal Carcinomas Using High-Density DNA Microarrays by Grützmann, Robert, Pilarsky, Christian, Ammerpohl, Ole, Luttges, Jutta, Böhme, Armin, Sipos, Bence, Foerder, Melanie, Alldinger, Ingo, Jahnke, Beatrix, Schackert, Hans Konrad, Kalthoff, Holger, Kremer, Bemd, Klöppel, Gunter, Saeger, Hans Detlev

“…Pancreatic ductal adenocarcinoma (PDAC) remains an important cause of malignancy-related death and is the eighth most common cancer with the lowest overall…”
Get full text

Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis by Rückert, Felix, Dawelbait, Gihan, Winter, Christof, Hartmann, Arndt, Denz, Axel, Ammerpohl, Ole, Schroeder, Michael, Schackert, Hans Konrad, Sipos, Bence, Klöppel, Günter, Kalthoff, Holger, Saeger, Hans-Detlev, Pilarsky, Christian, Grützmann, Robert

“…Pancreatic ductal adenocarcinoma (PDAC) remains an important cause of cancer death. Changes in apoptosis signaling in pancreatic cancer result in chemotherapy…”
Get full text

Therapy of Hematogenous Melanoma Brain Metastases with Endostatin by KIRSCH, Matthias, WEIGEL, Patrick, PINZER, Thomas, CARROLL, Rona S, BLACK, Peter Mcl, SCHACKERT, Hans-Konrad, SCHACKERT, Gabriele

“…Purpose: Cerebral metastases represent the most common type of brain tumors. This study investigated the effects of endogenous endostatin on hematogenous…”
Get full text

Functional Cathepsin C mutations cause different Papillon-Lefèvre syndrome phenotypes by Noack, Barbara, Görgens, Heike, Schacher, Beate, Puklo, Magda, Eickholz, Peter, Hoffmann, Thomas, Schackert, Hans Konrad

“…Aim: The autosomal‐recessive Papillon–Lefèvre syndrome (PLS) is characterized by severe aggressive periodontitis, combined with palmoplantar hyperkeratosis,…”
Get full text

Comparative genetic analysis of metachronous anaplastic oligoastrocytomas with extended recurrence-free interval by MARTINEZ, Ramon, SCHACKERT, Hans-Konrad, KIRSCH, Matthias, PAULUS, Werner, JOOS, Stefan, SCHACKERT, Gabriele

“…Two metachronous anaplastic oligoastrocytomas with different cerebral locations were analyzed in a 51-year-old patient with an extended recurrence-free…”
Get full text

Lack of association between Endoglin intron 7 insertion polymorphism and intracranial aneurysms in a white population : Evidence of racial/ethnic differences by KREX, Dietmar, ZIEGLER, Andreas, SCHACKERT, Hans Konrad, SCHACKERT, Gabriele

“…Endoglin is a component of the transforming growth factor-beta receptor complex and is predominantly expressed on cell surfaces of endothelial cells. A…”
Get full text

Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives by GRÜTZMANN, Robert, SAEGER, Hans Detlev, LIITTGES, Jutta, SCHACKERT, Hans Konrad, KALTHOFF, Holger, KLÖPPEL, Günter, PILARSKY, Christian

“…Pancreatic ductal adenocarcinoma has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and…”
Get full text

Missense variants in hMLH1 identified in patients from the German HNPCC consortium and functional studies by Hardt, Karin, Heick, Sven Boris, Betz, Beate, Goecke, Timm, Yazdanparast, Haniyeh, Küppers, Robin, Servan, Kati, Steinke, Verena, Rahner, Nils, Morak, Monika, Holinski-Feder, Elke, Engel, Christoph, Möslein, Gabriela, Schackert, Hans-Konrad, von Knebel Doeberitz, Magnus, Pox, Christian, Hegemann, Johannes H., Royer-Pokora, Brigitte

“…Missense mutations of the DNA mismatch repair gene MLH1 are found in a significant fraction of patients with Lynch syndrome (hereditary nonpolyposis colorectal…”
Get full text

Cytosine deaminase gene as a potential tool for the genetic therapy of colorectal cancer by Rowley, Simon, Lindauer, Marcus, Gebert, Johannes F., Haberkorn, Uwe, Oberdorfer, Franz, Moebius, Ulrich, Herfarth, Christian, Schackert, Hans-Konrad

“…The bacterial enzyme cytosine deaminase (CD) catalyzes the conversion of 5‐fluorocytosine (5‐FC) to the lethal 5‐fluorouracil (5‐FU) and so provides a useful…”
Get full text

Microsatellite instability analysis : A multicenter study for reliability and quality control by BOCKER, T, DIERMANN, J, WIRTZ, H.-C, FISHEL, R, RÜSCHOFF, J, FRIEDL, W, GEBERT, J, HOLINSKI-FEDER, E, KARNER-HANUSCH, J, VON KNEBEL-DOEBERITZ, M, KOELBLE, K, MOESLEIN, G, SCHACKERT, H.-K

“…The molecular biology section of the Hereditary Non-Polyposis Colorectal Cancer study group-Germany, instituted a multicenter study to test the reliability and…”
Get full text

Correspondence (reply): In reply by Steinke, Verena, Propping, Peter, Engel, Christoph, Büttner, Reinhard, Schackert, Konrad, Schmiegel, Wolf H

Get full text

Hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome by Steinke, Verena, Engel, Christoph, Büttner, Reinhard, Schackert, Hans Konrad, Schmiegel, Wolff H, Propping, Peter

“…Hereditary nonpolyposis colorectal cancer HNPCC, Lynch syndrome) is a genetic disease of autosomal dominant inheritance. It is caused by a mutation in one of…”
Get full text

In Reply by Steinke, Verena, Propping, Peter, Engel, Christoph, Büttner, Reinhard, Schackert, Konrad, Schmiegel, Wolf H.

Get full text

Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC by MORAK, Monika, SCHACKERT, Hans Konrad, KELLER, Gisela, KERKER, Brigitte, LEITNER, Gertraud, HOLINSKI-FEDER, Elke, RAHNER, Nils, BETZ, Beate, EBERT, Matthias, WALLDORF, Constanze, ROYER-POKORA, Brigitte, SCHULMANN, Karsten, VON KNEBEL-DOEBERITZ, Magnus, DIETMAIER, Wolfgang

“…Germline mutations in mismatch repair (MMR) genes, tumours with high microsatellite instability (MSI-H) and loss of MMR protein expression are the hallmarks of…”
Get full text

TLR4 and IL-18 gene variants in aggressive periodontitis by Noack, Barbara, Görgens, Heike, Lorenz, Katrin, Ziegler, Andreas, Hoffmann, Thomas, Schackert, Hans Konrad

“…Aim: We aimed to assess the association of different genotypes with increased aggressive periodontitis susceptibility by studying functional relevant variants…”
Get full text

Occult endometrial cancer and decision making for prophylactic hysterectomy in hereditary nonpolyposis colorectal cancer patients by Pistorius, Steffen, Kruger, Stefan, Hohl, Ruth, Plaschke, Jens, Distler, Wolfgang, Saeger, Hans-Detlev, Schackert, Hans Konrad

“…Hereditary nonpolyposis colorectal cancer (HNPCC) is the most frequent form of hereditary colorectal cancer. In addition to the high lifetime risk for…”
Get full text