Search Results - "Schacker, Timothy"

Persistent HIV-1 replication maintains the tissue reservoir during therapy by Lorenzo-Redondo, Ramon, Fryer, Helen R., Bedford, Trevor, Kim, Eun-Young, Archer, John, Kosakovsky Pond, Sergei L., Chung, Yoon-Seok, Penugonda, Sudhir, Chipman, Jeffrey G., Fletcher, Courtney V., Schacker, Timothy W., Malim, Michael H., Rambaut, Andrew, Haase, Ashley T., McLean, Angela R., Wolinsky, Steven M.

“…Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site associated with viral production, storage of viral particles in…”
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Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues by Fletcher, Courtney V., Staskus, Kathryn, Wietgrefe, Stephen W., Rothenberger, Meghan, Reilly, Cavan, Chipman, Jeffrey G., Beilman, Greg J., Khoruts, Alexander, Thorkelson, Ann, Schmidt, Thomas E., Anderson, Jodi, Perkey, Katherine, Stevenson, Mario, Perelson, Alan S., Douek, Daniel C., Haase, Ashley T., Schacker, Timothy W.

“…Antiretroviral therapy can reduce HIV-1 to undetectable levels in peripheral blood, but the effectiveness of treatment in suppressing replication in lymphoid…”
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Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption by Rothenberger, Meghan K., Keele, Brandon F., Wietgrefe, Stephen W., Fletcher, Courtney V., Beilman, Gregory J., Chipman, Jeffrey G., Khoruts, Alexander, Estes, Jacob D., Anderson, Jodi, Callisto, Samuel P., Schmidt, Thomas E., Thorkelson, Ann, Reilly, Cavan, Perkey, Katherine, Reimann, Thomas G., Utay, Netanya S., Makamdop, Krystelle Nganou, Stevenson, Mario, Douek, Daniel C., Haase, Ashley T., Schacker, Timothy W.

“…Significance Antiretroviral therapy (ART) effectively suppresses HIV replication; however, treatment cannot be stopped, because latently infected CD4+ T cells…”
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High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines by Pape, Kathryn A., Dileepan, Thamotharampillai, Kabage, Amanda J., Kozysa, Daria, Batres, Rodolfo, Evert, Clayton, Matson, Michael, Lopez, Sharon, Krueger, Peter D., Graiziger, Carolyn, Vaughn, Byron P., Shmidt, Eugenia, Rhein, Joshua, Schacker, Timothy W., Khoruts, Alexander, Jenkins, Marc K.

“…Although both infections and vaccines induce memory B cell (MBC) populations that participate in secondary immune responses, the MBCs generated in each case…”
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Defining total-body AIDS-virus burden with implications for curative strategies by Estes, Jacob D, Kityo, Cissy, Ssali, Francis, Swainson, Louise, Makamdop, Krystelle Nganou, Del Prete, Gregory Q, Deeks, Steven G, Luciw, Paul A, Chipman, Jeffrey G, Beilman, Gregory J, Hoskuldsson, Torfi, Khoruts, Alexander, Anderson, Jodi, Deleage, Claire, Jasurda, Jacob, Schmidt, Thomas E, Hafertepe, Michael, Callisto, Samuel P, Pearson, Hope, Reimann, Thomas, Schuster, Jared, Schoephoerster, Jordan, Southern, Peter, Perkey, Katherine, Shang, Liang, Wietgrefe, Stephen W, Fletcher, Courtney V, Lifson, Jeffrey D, Douek, Daniel C, McCune, Joseph M, Haase, Ashley T, Schacker, Timothy W

“…Quantifying the total-body virus burden in HIV-infected individuals is necessary to understand viral persistence and guide development of cure strategies…”
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Lymphoid tissue damage in HIV-1 infection depletes naïve T cells and limits T cell reconstitution after antiretroviral therapy by Zeng, Ming, Southern, Peter J, Reilly, Cavan S, Beilman, Greg J, Chipman, Jeffrey G, Schacker, Timothy W, Haase, Ashley T

“…Highly active antiretroviral therapy (HAART) can suppress HIV-1 replication and normalize the chronic immune activation associated with infection, but…”
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CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles by Leong, Yew Ann, Chen, Yaping, Ong, Hong Sheng, Wu, Di, Man, Kevin, Deleage, Claire, Minnich, Martina, Meckiff, Benjamin J, Wei, Yunbo, Hou, Zhaohua, Zotos, Dimitra, Fenix, Kevin A, Atnerkar, Anurag, Preston, Simon, Chipman, Jeffrey G, Beilman, Greg J, Allison, Cody C, Sun, Lei, Wang, Peng, Xu, Jiawei, Toe, Jesse G, Lu, Hao K, Tao, Yong, Palendira, Umaimainthan, Dent, Alexander L, Landay, Alan L, Pellegrini, Marc, Comerford, Iain, McColl, Shaun R, Schacker, Timothy W, Long, Heather M, Estes, Jacob D, Busslinger, Meinrad, Belz, Gabrielle T, Lewin, Sharon R, Kallies, Axel, Yu, Di

“…B cells and follicular helper T cells in B cell follicles can act as important reservoirs for chronic infection by viruses such as HIV or EBV. Yu and…”
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Lymphoid tissue structure and HIV-1 infection: life or death for T cells by Zeng, Ming, Haase, Ashley T, Schacker, Timothy W

“…Secondary lymphoid tissue (LT) structure facilitates immune responses and maintains homeostasis of T cells through production of survival factors, such as…”
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Translocated microbiome composition determines immunological outcome in treated HIV infection by Nganou-Makamdop, Krystelle, Talla, Aarthi, Sharma, Ashish Arunkumar, Darko, Sam, Ransier, Amy, Laboune, Farida, Chipman, Jeffrey G., Beilman, Gregory J., Hoskuldsson, Torfi, Fourati, Slim, Schmidt, Thomas E., Arumugam, Sahaana, Lima, Noemia S., Moon, Damee, Callisto, Samuel, Schoephoerster, Jordan, Tomalka, Jeffery, Mugyenyi, Peter, Ssali, Francis, Muloma, Proscovia, Ssengendo, Patrick, Leda, Ana R., Cheu, Ryan K., Flynn, Jacob K., Morou, Antigoni, Brunet-Ratnasingham, Elsa, Rodriguez, Benigno, Lederman, Michael M., Kaufmann, Daniel E., Klatt, Nichole R., Kityo, Cissy, Brenchley, Jason M., Schacker, Timothy W., Sekaly, Rafick P., Douek, Daniel C.

“…The impact of the microbiome on HIV disease is widely acknowledged although the mechanisms downstream of fluctuations in microbial composition remain…”
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HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation by Sékaly, Rafick-Pierre, Chomont, Nicolas, El-Far, Mohamed, Ancuta, Petronela, Trautmann, Lydie, Procopio, Francesco A, Yassine-Diab, Bader, Boucher, Geneviève, Boulassel, Mohamed-Rachid, Ghattas, Georges, Brenchley, Jason M, Schacker, Timothy W, Hill, Brenna J, Douek, Daniel C, Routy, Jean-Pierre, Haddad, Elias K

“…Highly active antiretroviral therapy is unable to eliminate HIV infection, because the virus persists in latently infected CD4 + T cells—a so-called virus…”
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The Defenders of the Alveolus Succumb in COVID-19 Pneumonia to SARS-CoV-2 and Necroptosis, Pyroptosis, and PANoptosis by Schifanella, Luca, Anderson, Jodi, Wieking, Garritt, Southern, Peter J, Antinori, Spinello, Galli, Massimo, Corbellino, Mario, Lai, Alessia, Klatt, Nichole, Schacker, Timothy W, Haase, Ashley T

“…Abstract Alveolar type II (ATII) pneumocytes as defenders of the alveolus are critical to repairing lung injury. We investigated the ATII reparative response…”
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Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial by Miller, Jeffrey S., Davis, Zachary B., Helgeson, Erika, Reilly, Cavan, Thorkelson, Ann, Anderson, Jodi, Lima, Noemia S., Jorstad, Siri, Hart, Geoffrey T., Lee, John H., Safrit, Jeffrey T., Wong, Hing, Cooley, Sarah, Gharu, Lavina, Chung, Hyunsoo, Soon-Shiong, Patrick, Dobrowolski, Curtis, Fletcher, Courtney V., Karn, Jonathan, Douek, Daniel C., Schacker, Timothy W.

“…There is no cure for HIV infection, and lifelong antiretroviral therapy (ART) is required. N-803 is an IL-15 superagonist comprised of an N72D mutant IL-15…”
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Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study by Cummins, Nathan W, Rizza, Stacey, Litzow, Mark R, Hua, Stephane, Lee, Guinevere Q, Einkauf, Kevin, Chun, Tae-Wook, Rhame, Frank, Baker, Jason V, Busch, Michael P, Chomont, Nicolas, Dean, Patrick G, Fromentin, Rémi, Haase, Ashley T, Hampton, Dylan, Keating, Sheila M, Lada, Steven M, Lee, Tzong-Hae, Natesampillai, Sekar, Richman, Douglas D, Schacker, Timothy W, Wietgrefe, Stephen, Yu, Xu G, Yao, Joseph D, Zeuli, John, Lichterfeld, Mathias, Badley, Andrew D

“…Notwithstanding 1 documented case of HIV-1 cure following allogeneic stem cell transplantation (allo-SCT), several subsequent cases of allo-SCT in HIV-1…”
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A novel wastewater-based epidemiology indexing method predicts SARS-CoV-2 disease prevalence across treatment facilities in metropolitan and regional populations by Melvin, Richard G., Hendrickson, Emily N., Chaudhry, Nabiha, Georgewill, Onimitein, Freese, Rebecca, Schacker, Timothy W., Simmons, Glenn E.

“…There is a need for wastewater based epidemiological (WBE) methods that integrate multiple, variously sized surveillance sites across geographic areas. We…”
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection by Douek, Daniel C, Brenchley, Jason M, Price, David A, Schacker, Timothy W, Asher, Tedi E, Silvestri, Guido, Rao, Srinivas, Kazzaz, Zachary, Bornstein, Ethan, Lambotte, Olivier, Altmann, Daniel, Blazar, Bruce R, Rodriguez, Benigno, Teixeira-Johnson, Leia, Landay, Alan, Martin, Jeffrey N, Hecht, Frederick M, Picker, Louis J, Lederman, Michael M, Deeks, Steven G

“…Chronic activation of the immune system is a hallmark of progressive HIV infection and better predicts disease outcome than plasma viral load, yet its etiology…”
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Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production by Du, Jing, Paz, Katelyn, Flynn, Ryan, Vulic, Ante, Robinson, Tara M., Lineburg, Katie E., Alexander, Kylie A., Meng, Jingjing, Roy, Sabita, Panoskaltsis-Mortari, Angela, Loschi, Michael, Hill, Geoffrey R., Serody, Jonathan S., Maillard, Ivan, Miklos, David, Koreth, John, Cutler, Corey S., Antin, Joseph H., Ritz, Jerome, MacDonald, Kelli P., Schacker, Timothy W., Luznik, Leo, Blazar, Bruce R.

“…Allogeneic hematopoietic stem cell transplantation is hampered by chronic graft-versus-host disease (cGVHD), resulting in multiorgan fibrosis and diminished…”
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Overcoming pharmacologic sanctuaries by Cory, Theodore J, Schacker, Timothy W, Stevenson, Mario, Fletcher, Courtney V

“…PURPOSE OF REVIEWCurrent antiretroviral treatment regimens represent significant improvements in the management of HIV-1 infection; however, these regimens…”
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Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections by Zeng, Ming, Smith, Anthony J, Wietgrefe, Stephen W, Southern, Peter J, Schacker, Timothy W, Reilly, Cavan S, Estes, Jacob D, Burton, Gregory F, Silvestri, Guido, Lifson, Jeffrey D, Carlis, John V, Haase, Ashley T

“…The hallmark of HIV-1 and SIV infections is CD4(+) T cell depletion. Both direct cell killing and indirect mechanisms related to immune activation have been…”
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Mathematical Modeling Predicts that Increased HSV-2 Shedding in HIV-1 Infected Persons Is Due to Poor Immunologic Control in Ganglia and Genital Mucosa by Schiffer, Joshua T, Swan, David A, Magaret, Amalia, Schacker, Timothy W, Wald, Anna, Corey, Lawrence

“…A signature feature of HIV infection is poor control of herpes virus infections, which reactivate from latency and cause opportunistic infections. While the…”
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Defining success with antiretroviral therapy by Schacker, Timothy W

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