Search Results - "Schachter, J B"

Second messenger cascade specificity and pharmacological selectivity of the human P2Y1‐purinoceptor by Schachter, Joel B., Li, Qing, Boyer, José L., Nicholas, Robert A., Harden, T. Kendall

“…1 . The coding sequence of the P2Y1‐purinoceptor was cloned from a human genomic library. 2 . The open reading frame encodes a protein of 373 amino acids that…”
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Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in mice by Schultz, M.K., Gentzel, R., Usenovic, M., Gretzula, C., Ware, C., Parmentier-Batteur, S., Schachter, J.B., Zariwala, H.A.

“…In Alzheimer's Disease (AD), tau pathology has a spatiotemporally distinct pattern of progressive spread along anatomically connected neural pathways…”
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Identification of competitive antagonists of the P2Y1 receptor by Boyer, J L, Romero-Avila, T, Schachter, J B, Harden, T K

“…Although P2 receptors mediate a myriad of physiological effects of extracellular adenine nucleotides, study of this broad class of receptors has been…”
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3-Isobutyl-1-methylxanthine increases alpha-1-adrenergic receptor sensitivity and density in DDT1-MF2 smooth muscle cells by Schachter, J B, Wolfe, B B

“…The effect of chronic exposure of DDT1-MF2 smooth muscle cells to the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) was investigated with…”
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HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors by SCHACHTER, J. B, SROMEK, S. M, NICHOLAS, R. A, HARDEN, T. K

“…Adenine and uridine nucleotide-promoted inositol phosphate accumulation was studied in HEK293 cells. Concentration effect curves for ADP, ATP, and 2ClATP were…”
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Competitive regulation of phospholipase C responses by cAMP and calcium by Schachter, J B, Ivins, J K, Pittman, R N, Wolfe, B B

“…DDT1-MF2 smooth muscle cells demonstrated a robust phospholipase C response to norepinephrine, as detected by inositol phosphate accumulation. A selective…”
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Cyclic AMP differentiates two separate but interacting pathways of phosphoinositide hydrolysis in the DDT1-MF2 smooth muscle cell line by Schachter, J B, Wolfe, B B

“…The activation of adenosine A1 receptors in DDT1-MF2 smooth muscle cells resulted in both the inhibition of agonist-stimulated cAMP accumulation and the…”
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Cdk5 as a drug target for the treatment of Alzheimer's disease by Lau, Lit-Fui, Seymour, Patricia A, Sanner, Mark A, Schachter, Joel B

“…Cyclin-dependent kinase-5 (cdk5) is suggested to play a role in tau phosphorylation and contribute to the pathogenesis of Alzheimer's disease (AD). One of its…”
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Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C by Schachter, Joel B., Boyer, José L., Li, Qing, Nicholas, Robert A., Harden, T. Kendall

“…1 The rat homologue of the P2Y1 receptor has been heterologously expressed in 1321N1 human astrocytoma cells and in C6 rat glioma cells. 2 As has been shown…”
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An examination of deoxyadenosine 5′(α‐thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor by Schachter, Joel B, Kendall Harden, T

“…The functional activity of deoxyadenosine 5′(α‐thio)triphosphate (dATPαS) was assessed at the cloned human P2Y1 receptor stably expressed in 1321N1 human…”
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The 6H1 Orphan Receptor, Claimed to Be the p2y5 Receptor, Does Not Mediate Nucleotide-Promoted Second Messenger Responses by Li, Qing, Schachter, Joel B., Harden, T.Kendall, Nicholas, Robert A.

“…An orphan G protein-coupled receptor, termed 6H1, with ∼30% sequence identity to P2Y receptors has been proposed to be a P2Y receptor (p2y5) based solely on a…”
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Synergistic activation of protein kinase C by arachidonic acid and diacylglycerols in vitro: generation of a stable membrane-bound, cofactor-independent state of protein kinase C activity by Schachter, Joel B., Lester, David S., Alkon, Daniel L.

“…The present study examines the synergistic activation of PKC by arachidonic acid and diacylglycerols in phospholipid vesicles and demonstrates that this…”
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Two algorithms for constructing a Delaunay triangulation by Lee, D. T., Schachter, B. J.

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Lack of Nucleotide-Promoted Second Messenger Signaling Responses in 1321N1 Cells Expressing the Proposed P2Y Receptor, p2y7 by Herold, Christopher L., Li, Qing, Schachter, Joel B., Harden, T.Kendall, Nicholas, Robert A.

“…A recently cloned G protein-coupled receptor (named the p2y7 receptor) with relatively low sequence identity to previously cloned P2Y receptors was proposed to…”
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Agonist action of adenosine triphosphates at the human P2Y1 receptor by Palmer, R K, Boyer, J L, Schachter, J B, Nicholas, R A, Harden, T K

“…The agonist selectivity for adenosine di- and triphosphates was determined for the human P2Y1 receptor stably expressed in human 1321N1 astrocytoma cells and…”
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Tau protein phosphorylation as a therapeutic target in Alzheimer's disease by Lau, Lit-Fui, Schachter, Joel B, Seymour, Patricia A, Sanner, Mark A

“…Neurofibrillary tangles (NFTs) are a distinguishing neuropathological feature found in postmortem brains of Alzheimer s disease (AD) and tauopathy patients…”
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A mutational analysis of residues essential for ligand recognition at the human P2Y1 receptor by Jiang, Q, Guo, D, Lee, B X, Van Rhee, A M, Kim, Y C, Nicholas, R A, Schachter, J B, Harden, T K, Jacobson, K A

“…We conducted a mutational analysis of residues potentially involved in the adenine nucleotide binding pocket of the human P2Y1 receptor. Mutated receptors were…”
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An examination of deoxyadenosine 5'( alpha -thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y sub(1) receptor by Schachter, J B, Harden, T K

“…The functional activity of deoxyadenosine 5'( alpha -thio)triphosphate (dATP alpha S) was assessed at the cloned human P2Y sub(1) receptor stably expressed in…”
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Second messenger cascade specificity and pharmacological selectivity of the human P 2Y1 ‐purinoceptor by Schachter, Joel B., Li, Qing, Boyer, José L., Nicholas, Robert A., Harden, T. Kendall

“…The coding sequence of the P 2Y1 ‐purinoceptor was cloned from a human genomic library. . The open reading frame encodes a protein of 373 amino acids that is…”
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HEK293 human embryonic kidney cells endogenously express the P2Y sub(1) and P2Y sub(2) receptors by Schachter, J B, Sromek, S M, Nicholas, R A, Harden, T K

“…Adenine and uridine nucleotide-promoted inositol phosphate accumulation was studied in HEK293 cells. Concentration effect curves for ADP, ATP, and 2ClATP were…”
Get full text