Search Results - "Schaaf, Marcel"

The Mineralocorticoid Receptor Plays a Crucial Role in Macrophage Development and Function by Faught, Erin, Schaaf, Marcel J M

“…Abstract Stress and the attendant rise in glucocorticoids (GCs) results in a potent suppression of the immune system. To date, the anti-inflammatory role of…”
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Molecular mechanisms of the stress-induced regulation of the inflammatory response in fish by Faught, Erin, Schaaf, Marcel J.M.

“…•Recent studies have shed novel light on how stress affects immunity in fish.•The role of fish MR and GR in immunomodulation by cortisol is reviewed.•Whereas…”
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Polystyrene nanoplastics disrupt glucose metabolism and cortisol levels with a possible link to behavioural changes in larval zebrafish by Brun, Nadja R., van Hage, Patrick, Hunting, Ellard R., Haramis, Anna-Pavlina G., Vink, Suzanne C., Vijver, Martina G., Schaaf, Marcel J. M., Tudorache, Christian

“…Plastic nanoparticles originating from weathering plastic waste are emerging contaminants in aquatic environments, with unknown modes of action in aquatic…”
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Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs by Xie, Yufei, Meijer, Annemarie H, Schaaf, Marcel J M

“…Dysregulation of the inflammatory response in humans can lead to various inflammatory diseases, like asthma and rheumatoid arthritis. The innate branch of the…”
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Functional characterization of the cannabinoid receptors 1 and 2 in zebrafish larvae using behavioral analysis by Luchtenburg, Floris J., Schaaf, Marcel J. M., Richardson, Michael K.

“…Rationale The endocannabinoid system (ECS) comprises the cannabinoids anandamide and 2-arachidonoylglycerol and the cannabinoid receptors 1 and 2 (Cnr1 and…”
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Transcriptional and Metabolic Effects of Glucocorticoid Receptor α and β Signaling in Zebrafish by Chatzopoulou, Antonia, Roy, Upasana, Meijer, Annemarie H, Alia, A, Spaink, Herman P, Schaaf, Marcel J. M

“…In humans and zebrafish, 2 glucocorticoid (GC) receptor (GR) splice variants exist: the canonical GR α-isoform (GRα), and the GRβ. In the present study, we…”
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Glucocorticoid-Induced Attenuation of the Inflammatory Response in Zebrafish by Chatzopoulou, Antonia, Heijmans, Jeroen P. M, Burgerhout, Erik, Oskam, Nienke, Spaink, Herman P, Meijer, Annemarie H, Schaaf, Marcel J. M

“…Glucocorticoids are steroid hormones that are secreted upon stress. Their effects are mediated by the glucocorticoid receptor, which acts as a transcription…”
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Corticosteroid Receptors in the Brain: Transcriptional Mechanisms for Specificity and Context-Dependent Effects by Meijer, Onno C., Buurstede, J. C., Schaaf, Marcel J. M.

“…Corticosteroid hormones act in the brain to support adaptation to stress via binding to mineralocorticoid and glucocorticoid receptors (MR and GR). These…”
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Covariation between behaviour and physiology indicators of coping style in zebrafish (Danio rerio) by Tudorache, Christian, Schaaf, Marcel J M, Slabbekoorn, Hans

“…All vertebrates exhibit physiological responses to a wide variety of stressors. The amplitude and profile of the response depend on the intensity, duration,…”
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Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration by Xie, Yufei, Tolmeijer, Sofie, Oskam, Jelle M, Tonkens, Tijs, Meijer, Annemarie H, Schaaf, Marcel J M

“…Glucocorticoid drugs are widely used to treat immune-related diseases, but their use is limited by side effects and by resistance, which especially occurs in…”
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Detailed Analysis of Zebrafish Larval Behaviour in the Light Dark Challenge Assay Shows That Diel Hatching Time Determines Individual Variation by Rock, Sebastian, Rodenburg, Frans, Schaaf, Marcel J M, Tudorache, Christian

“…Research on stress coping style, i.e., the response of an organism to adverse conditions, which is constant over time and context, gained momentum in recent…”
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Quantitation of glucocorticoid receptor DNA-binding dynamics by single-molecule microscopy and FRAP by Groeneweg, Femke L, van Royen, Martin E, Fenz, Susanne, Keizer, Veer I P, Geverts, Bart, Prins, Jurrien, de Kloet, E Ron, Houtsmuller, Adriaan B, Schmidt, Thomas S, Schaaf, Marcel J M

“…Recent advances in live cell imaging have provided a wealth of data on the dynamics of transcription factors. However, a consistent quantitative description of…”
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Biological clock function is linked to proactive and reactive personality types by Tudorache, Christian, Slabbekoorn, Hans, Robbers, Yuri, Hin, Eline, Meijer, Johanna H, Spaink, Herman P, Schaaf, Marcel J M

“…Many physiological processes in our body are controlled by the biological clock and show circadian rhythmicity. It is generally accepted that a robust rhythm…”
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Glucocorticoid-Induced Exacerbation of Mycobacterial Infection Is Associated With a Reduced Phagocytic Capacity of Macrophages by Xie, Yufei, Xie, Jiajun, Meijer, Annemarie H., Schaaf, Marcel J. M.

“…Glucocorticoids are effective drugs for treating immune-related diseases, but prolonged therapy is associated with an increased risk of various infectious…”
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Nuclear receptor research in zebrafish by Schaaf, Marcel J M

“…Nuclear receptors (NRs) form a superfamily of transcription factors that can be activated by ligands and are involved in a wide range of physiological…”
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Background Suppression in Imaging Gold Nanorods through Detection of Anti-Stokes Emission by Carattino, Aquiles, Keizer, Veer I.P., Schaaf, Marcel J.M., Orrit, Michel

“…Metallic nanoparticles have opened the possibility of imaging, tracking, and manipulating biological samples without time limitations. Their low…”
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Cortisol Acting Through the Glucocorticoid Receptor Is Not Involved in Exercise-Enhanced Growth, But Does Affect the White Skeletal Muscle Transcriptome in Zebrafish ( Danio rerio ) by Palstra, Arjan P, Mendez, Silvia, Dirks, Ron P, Schaaf, Marcel J M

“…Forced sustained swimming exercise at optimal speed enhances growth in many fish species, particularly through hypertrophy of the white skeletal muscle. The…”
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Application of a capillary electrophoresis–mass spectrometry metabolomics workflow in zebrafish larvae reveals new effects of cortisol by Mever, Marlien, Mamani‐Huanca, Maricruz, Faught, Erin, López‐Gonzálvez, Ángeles, Hankemeier, Thomas, Barbas, Coral, Schaaf, Marcel J. M., Ramautar, Rawi

“…In contemporary biomedical research, the zebrafish (Danio rerio) is increasingly considered a model system, as zebrafish embryos and larvae can (potentially)…”
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Discovery of a Functional Glucocorticoid Receptor β-Isoform in Zebrafish by Schaaf, Marcel J. M, Champagne, Danielle, van Laanen, Ivo H. C, van Wijk, Diane C. W. A, Meijer, Annemarie H, Meijer, Onno C, Spaink, Herman P, Richardson, Michael K

“…In humans, two glucocorticoid receptor (GR) splice variants exist: GRα and GRβ, which are identical between amino acids 1–727 and then diverge. Whereas GRα…”
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The adapter protein Myd88 plays an important role in limiting mycobacterial growth in a zebrafish model for tuberculosis by Hosseini, Rohola, Lamers, Gerda E. M., Bos, Erik, Hogendoorn, Pancras C. W., Koster, Abraham J., Meijer, Annemarie H., Spaink, Herman P., Schaaf, Marcel J. M.

“…Tuberculosis (TB) is the most prevalent bacterial infectious disease in the world, caused by the pathogen Mycobacterium tuberculosis ( Mtb ). In this study, we…”
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