Search Results - "Schaaf, Lea"

Renal effects of metallothionein induction by zinc in vitro and in vivo by Schanz, Moritz, Schaaf, Lea, Dippon, Juergen, Biegger, Dagmar, Fritz, Peter, Alscher, Mark Dominik, Kimmel, Martin

“…Metallothionein (MTT) is an endogenous antioxidant that can be induced by both zinc (Zn) and ischemia. In kidneys, increased MTT expression exerts a putative…”
Get full text

Dual targeting of MCL1 and NOXA as effective strategy for treatment of mantle cell lymphoma by Höring, Elisabeth, Montraveta, Arnau, Heine, Simon, Kleih, Markus, Schaaf, Lea, Vöhringer, Matthias C., Esteve‐Arenys, Anna, Roué, Gael, Colomer, Dolors, Campo, Elias, Ott, German, Aulitzky, Walter E., Kuip, Heiko

“…Summary Imbalances in the composition of BCL2 family proteins contribute to tumourigenesis and therapy resistance of mantle cell lymphoma (MCL), making these…”
Get full text

Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest by Schaaf, Lea, Schwab, Matthias, Ulmer, Christoph, Heine, Simon, Mürdter, Thomas E, Schmid, Jens O, Sauer, Georg, Aulitzky, Walter E, van der Kuip, Heiko

“…Although hyperthermia offers clinical appeal to sensitize cells to chemotherapy, this approach has been limited in terms of long-term outcome as well as…”
Get full text

Abstract 2223: Membranous expression of programmed cell death-ligand 1 (PDL1) on cancer cells is induced by cisplatin in an ATR dependent manner by Schaaf, Lea, Dong, Meng, Heine, Simon, van der Kuip, Heiko, Aulitzky, Walter E.

“…Cancer cells frequently develop strategies allowing to escape potential immune attacks by the host. One central component of this defense mechanism is the…”
Get full text

Abstract 2747: PARP inhibitors act synergistically with cisplatin and doxorubicin in BRCA competent cells by compromising chemotherapy-induced replication arrest by Schaaf, Lea, Schwab, Matthias, Heine, Simon, Aulitzky, Walter E., van der Kuip, Heiko

“…PARP inhibitors as monotherapy have emerged as promising antitumor drugs in particular for malignancies with nonfunctional BRCA1/2 proteins. Furthermore,…”
Get full text

A Temperature of 40 °C Appears to be a Critical Threshold for Potentiating Cytotoxic Chemotherapy In Vitro and in Peritoneal Carcinomatosis Patients Undergoing HIPEC by Schaaf, Lea, van der Kuip, Heiko, Zopf, Waltraud, Winter, Stefan, Münch, Marina, Mürdter, Thomas E., Thon, Klaus-Peter, Steurer, Wolfgang, Aulitzky, Walter E., Ulmer, Christoph

“…Background Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a radical but effective treatment option for patients with…”
Get full text

Abstract 3630: Inhibition of PARP by hyperthermia or pharmacological inhibitors synergize with cisplatin and doxorubicin but not with 5-FU or paclitaxel by Schaaf, Lea, Ulmer, Christoph, Steurer, Wolfgang, Mürdter, Thomas E., Aulitzky, Walter E., van der Kuip, Heiko

“…Short-term, high-dose chemotherapy together with hyperthermia (HIPEC) is widely used for treatment of peritoneal carcinomatosis. However, it is fairly known…”
Get full text

Abstract 3787: Effects of hyperthermia on DNA repair capacity and long term survival in ovarian and colon carcinoma cells by Schaaf, Lea, Kuip, Heiko Van Der, Mürdter, Thomas E., Ulmer, Christoph, Aulitzky, Walter E.

“…Background: Gynecological and gastrointestinal malignancies have the potential to spread into the peritoneal cavity. Peritoneal carcinomatosis is associated…”
Get full text

Abstract 2574: HIPEC for treatment of peritoneal carcinomatosis: 40°C is the critical threshold temperature for potentiating chemotherapy efficacy in vitro and in vivo by Schaaf, Lea, Münch, Marina, Steurer, Wolfgang, Aulitzky, Walter E., Mürdter, Thomas E., van der kuip, Heiko, Ulmer, Christoph

“…Hyperthermic intraperitoneal chemotherapy (HIPEC) combines circulated chemotherapy with enhanced temperature in the abdominal cavity of peritoneal carcinosis…”
Get full text

Abstract 3732: Combined targeting of NOXA and GSTpi effectively kills mantle cell lymphoma cells by Kleih, Markus, Heine, Simon, Dengler, Michael, Schaaf, Lea, Hoering, Elisabeth, Horn, Heike, Ott, German, Aulitzky, Walter E., van der Kuip, Heiko

“…Mantle cell lymphoma (MCL) is clinically characterized by an aggressive course and only transient response to chemotherapy. Therefore, new treatment strategies…”
Get full text