Search Results - "Schaaf, Cecilia R"

Cisplatin exhibits superiority over MMC as a perfusion agent in a peritoneal mesothelioma patient specific organoid HIPEC platform by Forsythe, Steven D., Erali, Richard A., Edenhoffer, Nicholas, Meeker, William, Wajih, Nadeem, Schaaf, Cecilia R., Laney, Preston, Vanezuela, Cristian D., Li, Wencheng, Levine, Edward A., Soker, Shay, Votanopoulos, Konstantinos I.

“…Peritoneal mesothelioma (PM) is a rare malignancy with poor prognosis, representing about 10–15% of all mesothelioma cases. Herein we apply PM patient-derived…”
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Culture of equine intestinal epithelial stem cells after delayed tissue storage for future applications by Stewart, Amy Stieler, Schaaf, Cecilia R, Veerasammy, Brittany, Freund, John M, Gonzalez, Liara M

“…Equine intestinal epithelial stem cells (ISCs) serve as potential targets to treat horses with severe intestinal injury. The ability to isolate and store ISCs…”
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Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment by Schaaf, Cecilia R, Gonzalez, Liara M

“…For both human and veterinary patients, non-infectious intestinal disease is a major cause of morbidity and mortality. To improve treatment of intestinal…”
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Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion by Abraham, Nader, Ludwig, Elsa K., Schaaf, Cecilia R., Veerasammy, Brittany, Stewart, Amy S., McKinney, Caroline, Freund, John, Brassil, John, Samy, Kannan P., Gao, Qimeng, Kahan, Riley, Niedzwiecki, Donna, Cardona, Diana M., Garman, Katherine S., Barbas, Andrew S., Sudan, Debra L., Gonzalez, Liara M.

“…Successful intestinal transplantation is currently hindered by graft injury that occurs during procurement and storage, which contributes to postoperative…”
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Enhancing the Efficacy of HIPEC Through Bromelain: A Preclinical Investigation in Appendiceal Cancer by Wajih, Nadeem, Erali, Richard A., Forsythe, Steven D., Schaaf, Cecilia R., Shen, Perry, Levine, Edward A., Soker, Shay, Morris, David L., Votanopoulos, Konstantinos I.

“…Introduction Appendiceal cancer (AC) excessive mucin production is a barrier to heated intraperitoneal chemotherapy (HIPEC) drug delivery. Bromelain is a…”
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A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease by Schaaf, Cecilia R., Polkoff, Kathryn M., Carter, Amber, Stewart, Amy S., Sheahan, Breanna, Freund, John, Ginzel, Joshua, Snyder, Joshua C., Roper, Jatin, Piedrahita, Jorge A., Gonzalez, Liara M.

“…Intestinal epithelial stem cells (ISCs) are responsible for intestinal epithelial barrier renewal; thereby, ISCs play a critical role in intestinal…”
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ASO Visual Abstract: Enhancing the Efficacy of HIPEC Through Bromelain: A Preclinical Investigation in Appendiceal Cancer by Wajih, Nadeem, Erali, Richard A., Forsythe, Steven D., Schaaf, Cecilia R., Shen, Perry, Levine, Edward A., Soker, Shay, Morris, David L., Votanopoulos, Konstantinos I.

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Comparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability by Ludwig, Elsa K., Abraham, Nader, Schaaf, Cecilia R., McKinney, Caroline A., Freund, John, Stewart, Amy S., Veerasammy, Brittany A., Thomas, Mallory, Cardona, Diana M., Garman, Katherine, Barbas, Andrew S., Sudan, Debra L., Gonzalez, Liara M.

“…Intestinal transplantation (IT) is the final treatment option for intestinal failure. Static cold storage (CS) is the standard preservation method used for…”
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In Vitro Three-Dimensional (3D) Models for Melanoma Immunotherapy by Nomdedeu-Sancho, Gemma, Gorkun, Anastasiya, Mahajan, Naresh, Willson, Kelsey, Schaaf, Cecilia R, Votanopoulos, Konstantinos I, Atala, Anthony, Soker, Shay

“…Melanoma is responsible for the majority of skin cancer-related fatalities. Immune checkpoint inhibitor (ICI) treatments have revolutionized the management of…”
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Utilizing Patient-Derived Organoids in the Management of Colorectal Cancer with Peritoneal Metastases: A Review of Current Literature by Erali, Richard A., Forsythe, Steven D., Gironda, Daniel J., Schaaf, Cecilia R., Wajih, Nadeem, Soker, Shay, Votanopoulos, Konstantinos I.

“…Introduction Treatment of colorectal cancer-derived peritoneal carcinomatosis (CRC-PC) is challenging due to cellular heterogeneity that exhibits variable…”
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Changes in equine intestinal stem/progenitor cell number at resection margins in cases of small intestinal strangulation by Veerasammy, Brittany, Gonzalez, Gabriel, Báez-Ramos, Patricia, Schaaf, Cecilia R, Stewart, Amy Stieler, Ludwig, Elsa K, McKinney-Aguirre, Caroline, Freund, John, Robertson, James, Gonzalez, Liara M

“…Intestinal epithelial stem cells (ISC) are responsible for epithelial regeneration and are critical to the intestine's ability to regain barrier function…”
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Immune-reactive tumor organoids system to determine the effects of microbial metabolites on cancer immunity and immunotherapies by El-Derby, Azza M., Schaaf, Cecilia R., Shelkey, Ethan, Cook, Katherine L., Votanopoulos, Konstantinos I., Soker, Shay

“…Immunotherapies are a revolutionary approach to treating cancer by utilizing the body’s immune system to target and combat cancer cells. This approach offers…”
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212.1: Normothermic Machine Perfusion and Orthotopic Allotransplantation of the Full Length Porcine Intestine by Abraham, Nader, Ludwig, Elsa K., Schaaf, Cecilia R., Veerasammy, Brittany, Stewart, Amy S., McKinney, Caroline, Freund, John, Samy, Kannan P., Gao, Qimeng, Kahan, Riley, Garman, Katherine S., Barbas, Andrew S., Gonzalez, Liara M., Sudan, Debra L.

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Abstract 19: Patient derived tumor-on-a-chip platform potentiates adaptive immune response against primary tumor cells by Schaaf, Cecilia R., Liu, Tiefu, Hutchins, Damian, Kooshki, Mitra, Wagner, Calvin, Edenhoffer, Nicholas, Forsythe, Steven, Greissinger, Robyn, Miller, Lance, Triozzi, Pierre, Levine, Edward, Soker, Shay, Hall, Adam R., Votanopoulos, Konstantinos I.

“…Background: Adoptive cellular therapy (ACT) is a promising antitumor immunotherapy showing success in select trials/patients. However, major challenges limit…”
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Abstract 4051: Microfluidic incubation of patient derived tumor and immune cells boosts lymphocyte cytotoxic phenotype by Hutchins, Damian C., Schaaf, Cecilia R., Edenhoffer, Nicholas P., Kooshki, Mitra, Greissenger, Robyn, Forsythe, Steven D., Hall, Adam R., Miller, Lance D., Soker, Shay, Triozzi, Pierre L., Votanopoulos, Konstantinos

“…Introduction: Tumor infiltrating lymphocytes (TILs), hold promise in advancing adoptive cell therapy for patients with otherwise limited treatment options…”
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Abstract 150: A 515 tumor specimens collection from surgery to benchtop: the WFORCE organoid experience in personalized research by Forsythe, Steven Donald, Erali, Richard A., Laney, Preston, Meeker, William, Abdulkhuseynova, Salomat, Wajih, Nadeem, Edenhoffer, Nicholas, Schaaf, Cecilia R., Sivakumar, Hemamyammal, Skardal, Aleksander, Strowd, Roy E., Tatter, Stephen B., Clark, Clancy J., Randle, Reese W., Shen, Perry, Levine, Edward A., D'Agostino, Ralph B., Soker, Shay, Votanopoulos, Konstantinos I.

“…Introduction: Patient tumor organoids (PTOs) are a new and developing preclinical model in cancer research. However, there is variation in protocols between…”
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