Search Results - "Schürch, M."

Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics by Matusiak, Magdalena, Schürch, Christian M

“…SARS-CoV-2 is causing a pandemic with currently > 29 million confirmed cases and > 900,000 deaths worldwide. The locations and mechanisms of virus entry into…”
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Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front by Schürch, Christian M., Bhate, Salil S., Barlow, Graham L., Phillips, Darci J., Noti, Luca, Zlobec, Inti, Chu, Pauline, Black, Sarah, Demeter, Janos, McIlwain, David R., Kinoshita, Shigemi, Samusik, Nikolay, Goltsev, Yury, Nolan, Garry P.

“…Antitumoral immunity requires organized, spatially nuanced interactions between components of the immune tumor microenvironment (iTME). Understanding this…”
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CODEX multiplexed tissue imaging with DNA-conjugated antibodies by Black, Sarah, Phillips, Darci, Hickey, John W., Kennedy-Darling, Julia, Venkataraaman, Vishal G., Samusik, Nikolay, Goltsev, Yury, Schürch, Christian M., Nolan, Garry P.

“…Advances in multiplexed imaging technologies have drastically improved our ability to characterize healthy and diseased tissues at the single-cell level…”
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Bispecific Antibodies for Multiple Myeloma: A Review of Targets, Drugs, Clinical Trials, and Future Directions by Caraccio, Chiara, Krishna, Sachi, Phillips, Darci J, Schürch, Christian M

“…Multiple myeloma (MM) is a plasma cell malignancy and the second most common hematological neoplasm in adults, comprising 1.8% of all cancers. With an annual…”
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Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma by Phillips, Darci, Matusiak, Magdalena, Gutierrez, Belén Rivero, Bhate, Salil S., Barlow, Graham L., Jiang, Sizun, Demeter, Janos, Smythe, Kimberly S., Pierce, Robert H., Fling, Steven P., Ramchurren, Nirasha, Cheever, Martin A., Goltsev, Yury, West, Robert B., Khodadoust, Michael S., Kim, Youn H., Schürch, Christian M., Nolan, Garry P.

“…Cutaneous T cell lymphomas (CTCL) are rare but aggressive cancers without effective treatments. While a subset of patients derive benefit from PD-1 blockade,…”
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Regulation of hematopoietic and leukemic stem cells by the immune system by Riether, C, Schürch, C M, Ochsenbein, A F

“…Hematopoietic stem cells (HSCs) are rare, multipotent cells that generate via progenitor and precursor cells of all blood lineages. Similar to normal…”
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A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma by Lytle, Nikki K., Ferguson, L. Paige, Rajbhandari, Nirakar, Gilroy, Kathryn, Fox, Raymond G., Deshpande, Anagha, Schürch, Christian M., Hamilton, Michael, Robertson, Neil, Lin, Wei, Noel, Pawan, Wartenberg, Martin, Zlobec, Inti, Eichmann, Micha, Galván, José A., Karamitopoulou, Eva, Gilderman, Tami, Esparza, Lourdes Adriana, Shima, Yutaka, Spahn, Philipp, French, Randall, Lewis, Nathan E., Fisch, Kathleen M., Sasik, Roman, Rosenthal, Sara Brin, Kritzik, Marcie, Von Hoff, Daniel, Han, Haiyong, Ideker, Trey, Deshpande, Aniruddha J., Lowy, Andrew M., Adams, Peter D., Reya, Tannishtha

“…Drug resistance and relapse remain key challenges in pancreatic cancer. Here, we have used RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq,…”
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Virtual and augmented reality for biomedical applications by Venkatesan, Mythreye, Mohan, Harini, Ryan, Justin R, Schürch, Christian M, Nolan, Garry P, Frakes, David H, Coskun, Ahmet F

“…3D visualization technologies such as virtual reality (VR), augmented reality (AR), and mixed reality (MR) have gained popularity in the recent decade. Digital…”
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Cytotoxic CD8+ T Cells Stimulate Hematopoietic Progenitors by Promoting Cytokine Release from Bone Marrow Mesenchymal Stromal Cells by Schürch, Christian M., Riether, Carsten, Ochsenbein, Adrian F.

“…Cytotoxic CD8+ T cells (CTLs) play a major role in host defense against intracellular pathogens, but a complete clearance of pathogens and return to…”
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A review on tumor heterogeneity and evolution in multiple myeloma: pathological, radiological, molecular genetics, and clinical integration by Schürch, Christian M., Rasche, Leo, Frauenfeld, Leonie, Weinhold, Niels, Fend, Falko

“…Recent research has dramatically advanced our understanding of the genetic basis of multiple myeloma (MM). MM displays enormous inter- and intratumoral…”
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Therapeutic Antibodies for Myeloid Neoplasms-Current Developments and Future Directions by Schürch, Christian M

“…Therapeutic monoclonal antibodies (mAbs) such as antibody-drug conjugates, ligand-receptor antagonists, immune checkpoint inhibitors and bispecific T cell…”
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CellSeg: a robust, pre-trained nucleus segmentation and pixel quantification software for highly multiplexed fluorescence images by Lee, Michael Y, Bedia, Jacob S, Bhate, Salil S, Barlow, Graham L, Phillips, Darci, Fantl, Wendy J, Nolan, Garry P, Schürch, Christian M

“…Algorithmic cellular segmentation is an essential step for the quantitative analysis of highly multiplexed tissue images. Current segmentation pipelines often…”
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CARving up colorectal cancer organoids in vitro by Schürch, Christian M.

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SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages by Martínez-Colón, Giovanny J, Ratnasiri, Kalani, Chen, Heping, Jiang, Sizun, Zanley, Elizabeth, Rustagi, Arjun, Verma, Renu, Chen, Han, Andrews, Jason R, Mertz, Kirsten D, Tzankov, Alexandar, Azagury, Dan, Boyd, Jack, Nolan, Garry P, Schürch, Christian M, Matter, Matthias S, Blish, Catherine A, McLaughlin, Tracey L

“…Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet…”
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Highly Multiplexed Phenotyping of Immunoregulatory Proteins in the Tumor Microenvironment by CODEX Tissue Imaging by Phillips, Darci, Schürch, Christian M, Khodadoust, Michael S, Kim, Youn H, Nolan, Garry P, Jiang, Sizun

“…Immunotherapies are revolutionizing cancer treatment by boosting the natural ability of the immune system. In addition to antibodies against traditional…”
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Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling by Balmer, Maria L, Schürch, Christian M, Saito, Yasuyuki, Geuking, Markus B, Li, Hai, Cuenca, Miguelangel, Kovtonyuk, Larisa V, McCoy, Kathy D, Hapfelmeier, Siegfried, Ochsenbein, Adrian F, Manz, Markus G, Slack, Emma, Macpherson, Andrew J

“…Neutropenia is probably the strongest known predisposition to infection with otherwise harmless environmental or microbiota-derived species. Because initial…”
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Organization of the human intestine at single-cell resolution by Hickey, John W., Becker, Winston R., Nevins, Stephanie A., Horning, Aaron, Perez, Almudena Espin, Zhu, Chenchen, Zhu, Bokai, Wei, Bei, Chiu, Roxanne, Chen, Derek C., Cotter, Daniel L., Esplin, Edward D., Weimer, Annika K., Caraccio, Chiara, Venkataraaman, Vishal, Schürch, Christian M., Black, Sarah, Brbić, Maria, Cao, Kaidi, Chen, Shuxiao, Zhang, Weiruo, Monte, Emma, Zhang, Nancy R., Ma, Zongming, Leskovec, Jure, Zhang, Zhengyan, Lin, Shin, Longacre, Teri, Plevritis, Sylvia K., Lin, Yiing, Nolan, Garry P., Greenleaf, William J., Snyder, Michael

“…The intestine is a complex organ that promotes digestion, extracts nutrients, participates in immune surveillance, maintains critical symbiotic relationships…”
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PET Imaging of the Natural Killer Cell Activation Receptor NKp30 by Shaffer, Travis M, Aalipour, Amin, Schürch, Christian M, Gambhir, Sanjiv S

“…Redirecting the immune system in cancer treatment has led to remarkable responses in a subset of patients. Natural killer (NK) cells are innate lymphoid cells…”
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Tyrosine kinase inhibitor-induced CD70 expression mediates drug resistance in leukemia stem cells by activating Wnt signaling by Riether, Carsten, Schürch, Christian M, Flury, Christoph, Hinterbrandner, Magdalena, Drück, Linda, Huguenin, Anne-Laure, Baerlocher, Gabriela M, Radpour, Ramin, Ochsenbein, Adrian F

“…In chronic myelogenous leukemia (CML), oncogenic BCR-ABL1 activates the Wnt pathway, which is fundamental for leukemia stem cell (LSC) maintenance. Tyrosine…”
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CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma by Pascual-Pasto, Guillem, McIntyre, Brendan, Hines, Margaret G., Giudice, Anna M., Garcia-Gerique, Laura, Hoffmann, Jennifer, Mishra, Pamela, Matlaga, Stephanie, Lombardi, Simona, Shraim, Rawan, Schürch, Patrick M., Yarmarkovich, Mark, Hofmann, Ted J., Alikarami, Fatemeh, Martinez, Daniel, Tsang, Matthew, Gil-de-Gómez, Luis, Spear, Timothy T., Bernt, Kathrin M., Wolpaw, Adam J., Dimitrov, Dimiter S., Li, Wei, Bosse, Kristopher R.

“…Novel chimeric antigen receptor (CAR) T-cell approaches are needed to improve therapeutic efficacy in solid tumors. High-risk neuroblastoma is an aggressive…”
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