Perineuronal nets of extracellular matrix around hippocampal interneurons resist destruction by activated microglia in trimethyltin-treated rats

The destruction of the extracellular matrix by inflammatory processes may induce neuronal dysfunction and accelerate neurodegeneration. We describe that chondroitin sulphate proteoglycan-immunoreactive perineuronal nets and the enwrapped interneurons persisted 2 weeks after trimethyltin intoxication...

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Bibliographic Details
Published in:	Brain research Vol. 958; no. 2; pp. 448 - 453
Main Authors:	Schüppel, Karin, Brauer, Kurt, Härtig, Wolfgang, Grosche, Jens, Earley, Bernadette, Leonard, Brian E, Brückner, Gert
Format:	Journal Article
Language:	English
Published:	London Elsevier B.V 27-12-2002 Amsterdam Elsevier New York, NY
Subjects:	Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - metabolism Hippocampus Hippocampus - drug effects Hippocampus - metabolism Interneurons - drug effects Interneurons - metabolism Male Medical sciences Metals and various inorganic compounds Microglia Microglia - drug effects Microglia - metabolism Neurodegeneration Oligodendroglia - drug effects Oligodendroglia - metabolism Rat Rats Rats, Sprague-Dawley Toxicology Trimethyltin Compounds - toxicity Disorders of the nervous system Extracellular matrix Rat Neurodegeneration Hippocampus Microglia Toxicity Neuroglia Rodentia Central nervous system Extracellular Heavy metal Interneuron Vertebrata Mammalia Animal Brain (vertebrata)
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Summary:	The destruction of the extracellular matrix by inflammatory processes may induce neuronal dysfunction and accelerate neurodegeneration. We describe that chondroitin sulphate proteoglycan-immunoreactive perineuronal nets and the enwrapped interneurons persisted 2 weeks after trimethyltin intoxication of rats (TMT, 8 mg/kg, i.p.) in all regions of the severely affected hippocampus and dentate gyrus, whereas the diffuse immunoreactivity around the CA2 pyramidal cells was reduced. Fluoro-Jade staining of degenerating neurons and staining of microglia by Griffonia simplicifolia agglutinin showed that net-associated neurons survived in the vicinity of damaged pyramidal cells and that perineuronal nets were not removed by activated microglia. We conclude that the extracellular matrix of perineuronal nets resists destruction after TMT treatment in the inflamed neural tissue. A permanent reconstitution of matrix components may be one of the factors that may support the viability of distinct types of neurons during neurodegenerative diseases.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(02)03569-2