Search Results - "Schönfelder, G."

Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology – Evolution versus revolution by Burgdorf, T., Piersma, A.H., Landsiedel, R., Clewell, R., Kleinstreuer, N., Oelgeschläger, M., Desprez, B., Kienhuis, A., Bos, P., de Vries, R., de Wit, L., Seidle, T., Scheel, J., Schönfelder, G., van Benthem, J., Vinggaard, A.M., Eskes, C., Ezendam, J.

“…At a joint workshop organized by RIVM and BfR, international experts from governmental institutes, regulatory agencies, industry, academia and animal welfare…”
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A prospective whole-mixture approach to assess risk of the food and chemical exposome by Tralau, T, Oelgeschläger, M, Kugler, J, Bloch, D, Braeuning, A, Burgdorf, T, Marx-Stoelting, P, Ritz, V, Schmeisser, S, Trubiroha, A, Zellmer, S, Luch, A, Schönfelder, G, Solecki, R, Hensel, A

“…Many widely used chemicals result in ubiquitous human exposure from multiple sources, including diet. Legislation mainly deals with the toxicological…”
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In Utero Exposure to Low Doses of Bisphenol A Lead to Long-term Deleterious Effects in the Vagina by Schönfelder, G., Flick, B., Mayr, E., Talsness, C., Paul, M., Chahoud, I.

“…The origins of the “endocrine disrupter hypothesis” may be traced to reports on adolescent daughters born to women who had taken the highly potent synthetic…”
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Cerebral endothelial cells release TNF-alpha after stimulation with cell walls of Streptococcus pneumoniae and regulate inducible nitric oxide synthase and ICAM-1 expression via autocrine loops by Freyer, D, Manz, R, Ziegenhorn, A, Weih, M, Angstwurm, K, Döcke, W D, Meisel, A, Schumann, R R, Schönfelder, G, Dirnagl, U, Weber, J R

“…TNF-alpha, inducible NO synthase (iNOS), and ICAM-1 are considered to be key proteins in the inflammatory response of most tissues. We tested the hypothesis…”
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Parent Bisphenol A Accumulation in the Human Maternal-Fetal-Placental Unit by Schönfelder, Gilbert, Wittfoht, Werner, Hopp, Hartmut, Talsness, Chris E., Paul, Martin, Chahoud, Ibrahim

“…Bisphenol A (BPA), an endocrine disruptor, is employed in the manufacture of a wide range of consumer products. The suggestion that BPA, at amounts to which we…”
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The perivascular contractile sheath of human placental stem villi: Its isolation and characterization by Graf, R, Schönfelder, G, Mühlberger, M, Gutsmann, M

“…Former studies have shown that fetal blood vessels of stem villi in the human placenta are enclosed by sheaths of presumed contractile cells. Efforts to prove…”
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Phosphorylation of vasodilator-stimulated phosphoprotein: a consequence of nitric oxide- and cGMP-mediated signal transduction in brain capillary endothelial cells and astrocytes by Sporbert, Anje, Mertsch, Katharina, Smolenski, Albert, Haseloff, Reiner F, Schönfelder, Gilbert, Paul, Martin, Ruth, Peter, Walter, Ulrich, Blasig, Ingolf E

“…There is contradictory information on the relevance of nitric oxide (NO) and cGMP for the function of brain capillary endothelial cells (BCEC) forming the…”
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Preeclampsia is associated with loss of neuronal nitric oxide synthase expression in vascular smooth muscle cells of the human umbilical cord by Schönfelder, G, Fuhr, N, Hadzidiakos, D, John, M, Hopp, H, Paul, M

“…Aims : Umbilical blood vessels are not innervated and regulation of blood flow to the placenta must depend on structural changes and the effect of vasoactive…”
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Expression of inducible nitric oxide synthase in placenta of women with gestational diabetes by Schönfelder, G, John, M, Hopp, H, Fuhr, N, van Der Giet, M, Paul, M

“…Gestational diabetes is one of the most prevalent medical complications of pregnancy and causes increased fetal wastage. Investigation of placentas from…”
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High Expression of Inducible Nitric Oxide Synthase Correlates with Intestinal Inflammation of Interleukin-2-Deficient Mice by HARREN, M., SCHÖNFELDER, G., PAUL, M., HORAK, I., RIECKEN, E. O., WIEDENMANN, B., JOHN, M.

“…Severely inflamed colonic sections of IL-2 (-/-) mice showed up to 19-fold increased iNOS mRNA levels. The level of iNOS protein expression corresponded to the…”
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Stretch-activated cation channel in human umbilical vein endothelium in normal pregnancy and in preeclampsia by Köhler, Ralf, Schönfelder, Gilbert, Hopp, Hartmut, Distler, Armin, Hoyer, Joachim

“…OBJECTIVETo determine whether stretch-activated cation channels (SAC) are present in intact human umbilical vein endothelium (HUVE) and in an endothelial cell…”
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Regulation of the endothelin system in transgenic rats expressing the human endothelin-2 gene by Liefeldt, L, Böcker, W, Schönfelder, G, Zintz, M, Paul, M

“…We have established a transgenic rat model for the expression of the human endothelin-2 (ET-2). These animals exhibit overexpression of the transgene in…”
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Transgenic rats expressing the human ET-2 gene : a model for the study of endothelin actions in vivo by LIEFELDT, L, SCHÖNFELDER, G, BÖCKER, W, HOCHER, B, TALSNESS, C. E, RETTIG, R, PAUL, M

“…Previous studies have characterized the endothelin peptides (ET-1, ET-2, ET-3) as strong vasoconstrictors which are possibly involved in the pathogenesis of…”
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Rethinking 3R strategies: Digging deeper into AnimalTestInfo promotes transparency in in vivo biomedical research by Bert, Bettina, Dörendahl, Antje, Leich, Nora, Vietze, Julia, Steinfath, Matthias, Chmielewska, Justyna, Hensel, Andreas, Grune, Barbara, Schönfelder, Gilbert

“…In the European Union (EU), animal welfare is seen as a matter of great importance. However, with respect to animal experimentation, European citizens feel…”
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Distribution of Constitutive Nitric Oxide Synthase Immunoreactivity and NADPH-Diaphorase Activity in Murine Telogen and Anagen Skin by Dippel, Edgar, Mayer, Bernd, Schönfelder, Gilbert, Czarnetzki, Beate M., Paus, Ralf

“…The freely diffusible radical nitric oxide is generated by nitric oxide synthase, and is a pleiotropic, bioregulatory molecule that regulates, e.g., the…”
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Zum Gebrauch der Schlaginstrumente im traditionellen chinesischen Musiktheater by Schönfelder, G.

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The biological impact of estrogens on gender differences in congestive heart failure by SCHONFELDER, G

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NO and Oxyradical Metabolism in New Cell Lines of Rat Brain Capillary Endothelial Cells Forming the Blood–Brain Barrier by Blasig, Ingolf E., Giese, Helga, Schroeter, Matthias L., Sporbert, Anje, Utepbergenov, Darkhan I., Buchwalow, Igor B., Neubert, Katrin, Schönfelder, Gilbert, Freyer, Dorette, Schimke, Ingolf, Siems, Wolf-Eberhard, Paul, Martin, Haseloff, Reiner F., Blasig, Rosel

“…To investigate the relevance of •NO and oxyradicals in the blood–brain barrier (BBB), differentiated and well-proliferating brain capillary endothelial cells…”
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In Utero Exposure to Low Doses of Bisphenol A Lead to Long-term Deleterious Effects in the Vagina1 by Schönfelder, G, Flick, B, Mayr, E, Talsness, C, Paul, M, Chahoud, I

“…The origins of the “endocrine disrupter hypothesis” may be traced to reports on adolescent daughters born to women who had taken the highly potent synthetic…”
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Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor by Jankowski, Joachim, Jankowski, Vera, Tölle, Markus, Vanholder, Raymond, Schönfelder, Gilbert, van der Giet, Markus, Henning, Lars, Schlüter, Hartmut, Paul, Martin, Zidek, Walter

“…Beyond serving as a mechanical barrier, the endothelium has important regulatory functions. The discovery of nitric oxide revolutionized our understanding of…”
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