Search Results - "Schönenberger, Désirée"

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice by Hoefflin, Rouven, Harlander, Sabine, Schäfer, Silvia, Metzger, Patrick, Kuo, Fengshen, Schönenberger, Désirée, Adlesic, Mojca, Peighambari, Asin, Seidel, Philipp, Chen, Chia-yi, Consenza-Contreras, Miguel, Jud, Andreas, Lahrmann, Bernd, Grabe, Niels, Heide, Danijela, Uhl, Franziska M., Chan, Timothy A., Duyster, Justus, Zeiser, Robert, Schell, Christoph, Heikenwalder, Mathias, Schilling, Oliver, Hakimi, A. Ari, Boerries, Melanie, Frew, Ian J.

“…Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal cell carcinomas (ccRCC), leading to accumulation of the HIF-1α…”
Get full text

Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice by Harlander, Sabine, Schönenberger, Désirée, Toussaint, Nora C, Prummer, Michael, Catalano, Antonella, Brandt, Laura, Moch, Holger, Wild, Peter J, Frew, Ian J

“…Through combined deletion of Vhl , Trp53 and Rb1 in renal epithelial cells, the authors develop a new mouse model of renal cell carcinoma that recapitulates…”
Get full text

Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1α and HIF2α by Schönenberger, Désirée, Harlander, Sabine, Rajski, Michal, Jacobs, Robert A, Lundby, Anne-Kristine, Adlesic, Mojca, Hejhal, Tomas, Wild, Peter J, Lundby, Carsten, Frew, Ian J

“…The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in the majority of clear cell renal cell carcinomas (ccRCC), but genetic ablation of Vhl alone…”
Get full text

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice by Albers, Joachim, Rajski, Michal, Schönenberger, Désirée, Harlander, Sabine, Schraml, Peter, von Teichman, Adriana, Georgiev, Strahil, Wild, Peter J., Moch, Holger, Krek, Wilhelm, Frew, Ian J.

“…The combinations of genetic alterations that cooperate with von Hippel–Lindau ( VHL ) mutation to cause clear cell renal cell carcinoma (ccRCC) remain poorly…”
Get full text

Combined Vhl, Trp53 and Rb1 mutation causes clear cell renal cell carcinoma in mice by Harlander, Sabine, Schönenberger, Désirée, Toussaint, Nora C., Prummer, Michael, Catalano, Antonella, Brandt, Laura, Moch, Holger, Wild, Peter J., Frew, Ian J.

“…Clear cell renal cell carcinomas (ccRCC) frequently exhibit inactivation of the VHL tumour suppressor gene and often harbour multiple copy number alterations…”
Get full text

Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis by Schönenberger, Désirée, Rajski, Michal, Harlander, Sabine, Frew, Ian J

“…One of the earliest requirements for the formation of a solid tumor is the establishment of an adequate blood supply. Clear cell renal cell carcinomas (ccRCC)…”
Get full text