Search Results - "Schönefeldt, Susann"

The Intracellular Sensor NOD2 Induces MicroRNA-29 Expression in Human Dendritic Cells to Limit IL-23 Release by Brain, Oliver, Owens, Benjamin M.J., Pichulik, Tica, Allan, Philip, Khatamzas, Elham, Leslie, Alasdair, Steevels, Tessa, Sharma, Sameer, Mayer, Alice, Catuneanu, Ana Maria, Morton, Victoria, Sun, Mei-Yi, Jewell, Derek, Coccia, Margherita, Harrison, Oliver, Maloy, Kevin, Schönefeldt, Susann, Bornschein, Simon, Liston, Adrian, Simmons, Alison

“…NOD2 is an intracellular sensor that contributes to immune defense and inflammation. Here we investigated whether NOD2 mediates its effects through control of…”
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IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis by Humblet-Baron, Stéphanie, MD, PhD, Franckaert, Dean, MSc, Dooley, James, MSc, Bornschein, Simon, MSc, Cauwe, Bénédicte, PhD, Schönefeldt, Susann, MSc, Bossuyt, Xavier, MD, PhD, Matthys, Patrick, PhD, Baron, Frédéric, MD, PhD, Wouters, Carine, MD, PhD, Liston, Adrian, PhD

“…Background Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8+ T-cell activation. HLH occurs as both acquired…”
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Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells by Pierson, Wim, Cauwe, Bénédicte, Policheni, Antonia, Schlenner, Susan M, Franckaert, Dean, Berges, Julien, Humblet-Baron, Stephanie, Schönefeldt, Susann, Herold, Marco J, Hildeman, David, Strasser, Andreas, Bouillet, Philippe, Lu, Li-Fan, Matthys, Patrick, Freitas, Antonio A, Luther, Rita J, Weaver, Casey T, Dooley, James, Gray, Daniel H D, Liston, Adrian

“…The signals controlling T reg cell homeostasis and survival are still being determined. Liston and colleagues demonstrate that peripheral T reg cells depend…”
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The Diverse Roles of γδ T Cells in Cancer: From Rapid Immunity to Aggressive Lymphoma by Schönefeldt, Susann, Wais, Tamara, Herling, Marco, Mustjoki, Satu, Bekiaris, Vasileios, Moriggl, Richard, Neubauer, Heidi A

“…γδ T cells are unique players in shaping immune responses, lying at the intersection between innate and adaptive immunity. Unlike conventional αβ T cells, γδ T…”
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Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia by Suske, Tobias, Sorger, Helena, Manhart, Gabriele, Ruge, Frank, Prutsch, Nicole, Zimmerman, Mark W, Eder, Thomas, Abdallah, Diaaeldin I, Maurer, Barbara, Wagner, Christina, Schönefeldt, Susann, Spirk, Katrin, Pichler, Alexander, Pemovska, Tea, Schweicker, Carmen, Pölöske, Daniel, Hubanic, Emina, Jungherz, Dennis, Müller, Tony Andreas, Aung, Myint Myat Khine, Orlova, Anna, Pham, Ha Thi Thanh, Zimmel, Kerstin, Krausgruber, Thomas, Bock, Christoph, Müller, Mathias, Dahlhoff, Maik, Boersma, Auke, Rülicke, Thomas, Fleck, Roman, de Araujo, Elvin Dominic, Gunning, Patrick Thomas, Aittokallio, Tero, Mustjoki, Satu, Sanda, Takaomi, Hartmann, Sylvia, Grebien, Florian, Hoermann, Gregor, Haferlach, Torsten, Staber, Philipp Bernhard, Neubauer, Heidi Anne, Look, Alfred Thomas, Herling, Marco, Moriggl, Richard

“…T cell acute lymphoblastic leukemia (T-ALL) is an aggressive immature T cell cancer. Mutations in IL7R have been analyzed genetically, but downstream effector…”
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Rapamycin increases survival in ALS mice lacking mature lymphocytes by Staats, Kim A, Hernandez, Sara, Schönefeldt, Susann, Bento-Abreu, André, Dooley, James, Van Damme, Philip, Liston, Adrian, Robberecht, Wim, Van Den Bosch, Ludo

“…Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative disease. Disease pathophysiology is complex and not yet fully understood,…”
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Cytotoxic T-lymphocyte-associated protein 4-Ig effectively controls immune activation and inflammatory disease in a novel murine model of leaky severe combined immunodeficiency by Humblet-Baron, Stéphanie, Schönefeldt, Susann, Garcia-Perez, Josselyn E., Baron, Frédéric, Pasciuto, Emanuela, Liston, Adrian

“…Severe combined immunodeficiency can be caused by loss-of-function mutations in genes involved in the DNA recombination machinery, such as…”
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High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma by Garcha, Harsimran Kaur, Nawar, Nabanita, Sorger, Helena, Erdogan, Fettah, Aung, Myint Myat Khine, Sedighi, Abootaleb, Manaswiyoungkul, Pimyupa, Seo, Hyuk-Soo, Schönefeldt, Susann, Pölöske, Daniel, Dhe-Paganon, Sirano, Neubauer, Heidi A, Mustjoki, Satu M, Herling, Marco, de Araujo, Elvin D, Moriggl, Richard, Gunning, Patrick T

“…NK/T-cell lymphoma (NKTCL) and γδ T-cell non-Hodgkin lymphomas (γδ T-NHL) are highly aggressive lymphomas that lack rationally designed therapies and rely on…”
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Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice by Staats, Kim A, Pombal, Diana, Schönefeldt, Susann, Van Helleputte, Lawrence, Maurin, Hervé, Dresselaers, Tom, Govaerts, Kristof, Himmelreich, Uwe, Van Leuven, Fred, Van Den Bosch, Ludo, Dooley, James, Humblet-Baron, Stephanie, Liston, Adrian

“…Abstract Myelin is essential for efficient signal transduction in the nervous system comprising of multiple proteins. The intricacies of the regulation of the…”
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Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis by Staats, Kim A, Schönefeldt, Susann, Van Rillaer, Marike, Van Hoecke, Annelies, Van Damme, Philip, Robberecht, Wim, Liston, Adrian, Van Den Bosch, Ludo

“…Beta-2 microglobulin (β2m) is an essential component of the major histocompatibility complex (MHC) class I proteins and in the nervous system β2m is…”
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The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity by Dooley, James, Garcia-Perez, Josselyn E, Sreenivasan, Jayasree, Schlenner, Susan M, Vangoitsenhoven, Roman, Papadopoulou, Aikaterini S, Tian, Lei, Schonefeldt, Susann, Serneels, Lutgarde, Deroose, Christophe, Staats, Kim A, Van der Schueren, Bart, De Strooper, Bart, McGuinness, Owen P, Mathieu, Chantal, Liston, Adrian

“…The microRNA-29 (miR-29) family is among the most abundantly expressed microRNA in the pancreas and liver. Here, we investigated the function of miR-29 in…”
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Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes by Dooley, James, Tian, Lei, Schonefeldt, Susann, Delghingaro-Augusto, Viviane, Garcia-Perez, Josselyn E, Pasciuto, Emanuela, Di Marino, Daniele, Carr, Edward J, Oskolkov, Nikolay, Lyssenko, Valeriya, Franckaert, Dean, Lagou, Vasiliki, Overbergh, Lut, Vandenbussche, Jonathan, Allemeersch, Joke, Chabot-Roy, Genevieve, Dahlstrom, Jane E, Laybutt, D Ross, Petrovsky, Nikolai, Socha, Luis, Gevaert, Kris, Jetten, Anton M, Lambrechts, Diether, Linterman, Michelle A, Goodnow, Chris C, Nolan, Christopher J, Lesage, Sylvie, Schlenner, Susan M, Liston, Adrian

“…Adrian Liston and colleagues use a transgenic mouse model to demonstrate that beta cell failure is a mechanistic commonality in type 1 and type 2 diabetes…”
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Abstract 2752: The gain-of-function STAT5BN642H mutation as a driver of mature T cell leukemia/lymphoma by Neubauer, Heidi A., Suske, Tobias, Schönefeldt, Susann, Tangermann, Simone, Boersma, Auke, Rülicke, Thomas, Bekiaris, Vasileios, Kenner, Lukas, Moriggl, Richard

“…Mature T cell leukemias/lymphomas (MaTCL) are a group of rare hematological malignancies of mostly incurable prospects due to limited efficient therapies and a…”
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CTLA4-Ig effectively controls immune activation and inflammatory disease in a novel murine model of leaky SCID by Humblet-Baron, Stéphanie, MD, PhD, Schönefeldt, Susann, MSc, Garcia-Perez, Josselyn, MSc, Baron, Frédéric, MD, PhD, Pasciuto, Emanuela, PhD, Liston, Adrian, PhD

“…Abstract Background Severe combined immunodeficiency (SCID) can be caused by loss-of-function mutations in genes involved in the DNA recombination machinery,…”
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Type 1 diabetes in NOD mice unaffected by mast cell deficiency by Gutierrez, Dario A, Fu, Wenxian, Schonefeldt, Susann, Feyerabend, Thorsten B, Ortiz-Lopez, Adriana, Lampi, Yulia, Liston, Adrian, Mathis, Diane, Rodewald, Hans-Reimer

“…Mast cells have been invoked as important players in immune responses associated with autoimmune diseases. Based on in vitro studies, or in vivo through the…”
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Excessive Anti-Viral CD8 T Cell Activation Inverts the IL-2 Consumptive Hierarchy Triggering Regulatory T Cell Collapse in Mouse Model for Hemophagocytic Lymphohistiocytosis by Humblet-Baron, Stephanie, Franckaert, Dean, Bornschein, Simon, Cauwe, Bénédicte, Schonefeldt, Susann, Wouters, Carine, Matthys, Patrick, Baron, Frederic, Liston, Adrian

“…Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory condition driven by excessive CD8+ T cell activation. HLH occurs in both acquired and…”
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Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice by Tian, Lei, De Hertogh, Gert, Fedeli, Maya, Staats, Kim A, Schonefeldt, Susann, Humblet-Baron, Stephanie, Van Den Bosch, Ludo, Dellabona, Paolo, Dooley, James, Liston, Adrian

“…Abstract With an increasing number of studies demonstrating alterations in T cell microRNA expression during autoimmune disease, modulation of the T cell…”
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Anti-apoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells by Pierson, Wim, Cauwe, Bénédicte, Policheni, Antonia, Schlenner, Susan M., Franckaert, Dean, Berges, Julien, Humblet-Baron, Stephanie, Schonefeldt, Susann, Herold, Marco J., Hildeman, David, Strasser, Andreas, Bouillet, Philippe, Lu, Li-Fan, Matthys, Patrick, Freitas, Antonio A., Luther, Rita J., Weaver, Casey T., Dooley, James, Gray, Daniel H. D., Liston, Adrian

“…Foxp3 + regulatory T (T reg ) cells are a crucial immunosuppressive population of CD4 + T cells, yet the homeostatic processes and survival programs that…”
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