Search Results - "Schäffer, Lauge"

Discovery of the Once-Weekly Glucagon-Like Peptide‑1 (GLP-1) Analogue Semaglutide by Lau, Jesper, Bloch, Paw, Schäffer, Lauge, Pettersson, Ingrid, Spetzler, Jane, Kofoed, Jacob, Madsen, Kjeld, Knudsen, Lotte Bjerre, McGuire, James, Steensgaard, Dorte Bjerre, Strauss, Holger Martin, Gram, Dorte X, Knudsen, Sanne Møller, Nielsen, Flemming Seier, Thygesen, Peter, Reedtz-Runge, Steffen, Kruse, Thomas

“…Liraglutide is an acylated glucagon-like peptide-1 (GLP-1) analogue that binds to serum albumin in vivo and is approved for once-daily treatment of diabetes as…”
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Development of Cagrilintide, a Long-Acting Amylin Analogue by Kruse, Thomas, Hansen, Jakob Lerche, Dahl, Kirsten, Schäffer, Lauge, Sensfuss, Ulrich, Poulsen, Christian, Schlein, Morten, Hansen, Ann Maria Kruse, Jeppesen, Claus Bekker, Dornonville de la Cour, Charlotta, Clausen, Trine Ryberg, Johansson, Eva, Fulle, Simone, Skyggebjerg, Rikke Bjerring, Raun, Kirsten

“…A hallmark of the pancreatic hormone amylin is its high propensity toward the formation of amyloid fibrils, which makes it a challenging drug design effort…”
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Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography by Johansson, Eva, Hansen, Jakob Lerche, Hansen, Ann Maria Kruse, Shaw, Allan Christian, Becker, Peter, Schäffer, Lauge, Reedtz-Runge, Steffen

“…Calcitonin is a peptide hormone consisting of 32 amino acid residues and the calcitonin receptor is a Class B G protein-coupled receptor (GPCR). The crystal…”
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Real-time trafficking and signaling of the glucagon-like peptide-1 receptor by Roed, Sarah Noerklit, Wismann, Pernille, Underwood, Christina Rye, Kulahin, Nikolaj, Iversen, Helle, Cappelen, Karen Arevad, Schäffer, Lauge, Lehtonen, Janne, Hecksher-Soerensen, Jacob, Secher, Anna, Mathiesen, Jesper Mosolff, Bräuner-Osborne, Hans, Whistler, Jennifer L., Knudsen, Sanne Moeller, Waldhoer, Maria

“…•For the first time, we show real-time internalization of a family B GPCR.•GLP-1R internalizes rapidly in response to various agonists.•Ligand-induced GLP-1R…”
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A novel high-affinity peptide antagonist to the insulin receptor by Schäffer, Lauge, Brand, Christian L., Hansen, Bo F., Ribel, Ulla, Shaw, Allan C., Slaaby, Rita, Sturis, Jeppe

“…In this publication we describe a peptide insulin receptor antagonist, S661, which is a single chain peptide of 43 amino acids. The affinity of S661 for the…”
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Agonism and antagonism at the insulin receptor by Knudsen, Louise, Hansen, Bo Falck, Jensen, Pia, Pedersen, Thomas Åskov, Vestergaard, Kirsten, Schäffer, Lauge, Blagoev, Blagoy, Oleksiewicz, Martin B, Kiselyov, Vladislav V, De Meyts, Pierre

“…Insulin can trigger metabolic as well as mitogenic effects, the latter being pharmaceutically undesirable. An understanding of the structure/function…”
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Activation of the Insulin Receptor by Insulin and a Synthetic Peptide Leads to Divergent Metabolic and Mitogenic Signaling and Responses by Jensen, Maja, Hansen, Bente, De Meyts, Pierre, Schäffer, Lauge, Ursø, Birgitte

“…Recently, single chain peptides have been designed that target the insulin receptor and mimic insulin action. The aim of this study is to explore if activation…”
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Albumin Binding of Acylated Insulin (NN304) Does Not Deter Action to Stimulate Glucose Uptake by Dea, Melvin K, Hamilton-Wessler, Marianthe, Ader, Marilyn, Moore, Donna, Schäffer, Lauge, Loftager, Mette, Vølund, Aage, Bergman, Richard N

“…Albumin Binding of Acylated Insulin (NN304) Does Not Deter Action to Stimulate Glucose Uptake Melvin K. Dea 1 , Marianthe Hamilton-Wessler 1 , Marilyn Ader 1 ,…”
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The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss by Secher, Anna, Jelsing, Jacob, Baquero, Arian F, Hecksher-Sørensen, Jacob, Cowley, Michael A, Dalbøge, Louise S, Hansen, Gitte, Grove, Kevin L, Pyke, Charles, Raun, Kirsten, Schäffer, Lauge, Tang-Christensen, Mads, Verma, Saurabh, Witgen, Brent M, Vrang, Niels, Bjerre Knudsen, Lotte

“…Liraglutide is a glucagon-like peptide-1 (GLP-1) analog marketed for the treatment of type 2 diabetes. Besides lowering blood glucose, liraglutide also reduces…”
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Assembly of High-Affinity Insulin Receptor Agonists and Antagonists from Peptide Building Blocks by Schäffer, Lauge, Brissette, Renee E., Spetzler, Jane C., Pillutla, Renuka C., Østergaard, Søren, Lennick, Michael, Brandt, Jakob, Fletcher, Paul W., Danielsen, Gillian M., Hsiao, Ku-Chuan, Andersen, Asser S., Dedova, Olga, Ribel, Ulla, Hoeg-Jensen, Thomas, Hansen, Per Hertz, Blume, Arthur J., Markussen, Jan, Goldstein, Neil I.

“…Insulin is thought to elicit its effects by crosslinking the two extracellular α-subunits of its receptor, thereby inducing a conformational change in the…”
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A model for insulin binding to the insulin receptor by SCHÄFFER, Lauge

“…The affinities of a number of insulin analogues for the human insulin receptor, a truncated soluble form of the insulin receptor, and the human insulin‐like…”
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Hybrid Receptors Formed by Insulin Receptor (IR) and Insulin-like Growth Factor I Receptor (IGF-IR) Have Low Insulin and High IGF-1 Affinity Irrespective of the IR Splice Variant by Slaaby, Rita, Schäffer, Lauge, Lautrup-Larsen, Inger, Andersen, Asser Sloth, Shaw, Allan Christian, Mathiasen, Ida Stenfeldt, Brandt, Jakob

“…Insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) are both from the same subgroup of receptor tyrosine kinases that exist as covalently…”
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Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use by KURTZHALS, P, SCHÄFFER, L, SØRENSEN, A, KRISTENSEN, C, JONASSEN, I, SCHMID, C, TRÜB, T

“…Correlations of receptor binding and metabolic and mitogenic potencies of insulin analogs designed for clinical use. P Kurtzhals , L Schäffer , A Sørensen , C…”
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Activation of the insulin receptor (IR) by insulin and a synthetic peptide has different effects on gene expression in IR-transfected L6 myoblasts by Jensen, Maja, Palsgaard, Jane, Borup, Rehannah, de Meyts, Pierre, Schäffer, Lauge

“…Single-chain peptides have been recently produced that display either mimetic or antagonistic properties against the insulin and IGF-1 (insulin-like growth…”
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Beta cell specific probing with fluorescent exendin-4 is progressively reduced in type 2 diabetic mouse models by Lehtonen, Janne, Schäffer, Lauge, Rasch, Morten Grønbech, Hecksher-Sørensen, Jacob, Ahnfelt-Rønne, Jonas

“…Probes based on GLP-1R agonist exendin-4 have shown promise as in vivo β cell tracers. However, questions remain regarding the β cell specificity of exendin-4…”
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Ferret islet amyloid polypeptide (IAPP): characterization of in vitro and in vivo amyloidogenicity by Paulsson, Johan F., Benoit-Biancamano, Marie-Odile, Schäffer, Lauge, Dahl, Kirsten

“…Diabetes in the domestic ferret (Mustela putorius furo) has previously been described and the purpose of this study was to evaluate if the ferret could serve…”
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Crystal structure of the calcitonin receptor ectodomain in complex with a truncated salmon calcitonin analogue by Johansson, Eva, Hansen, Jakob L., Hansen, Ann Maria K., Shaw, Allan C., Becker, Peter, Schäffer, Lauge, Reedtz-Runge, Steffen

“…Abstract only…”
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Total Synthesis of desB30 Insulin Analogues by Biomimetic Folding of Single-Chain Precursors by Tofteng, A. Pernille, Jensen, Knud J., Schäffer, Lauge, Hoeg-Jensen, Thomas

“…Insulin is a peptide hormone consisting of 51 amino acids in two chains with three disulfide bridges. Human insulin and various analogues are used for the…”
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Insulins with built-in glucose sensors for glucose responsive insulin release by Hoeg-Jensen, Thomas, Ridderberg, Signe, Havelund, Svend, Schäffer, Lauge, Balschmidt, Per, Jonassen, Ib, Vedsø, Per, Olesen, Preben H., Markussen, Jan

“…Derivatization of insulin with phenylboronic acids is described, thereby equipping insulin with novel glucose sensing ability. It is furthermore demonstrated…”
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Salmon calcitonin distributes into the arcuate nucleus to a subset of NPY neurons in mice by Zakariassen, Hannah Louise, John, Linu Mary, Lykkesfeldt, Jens, Raun, Kirsten, Glendorf, Tine, Schaffer, Lauge, Lundh, Sofia, Secher, Anna, Lutz, Thomas Alexander, Le Foll, Christelle

“…The amylin receptor (AMY) and calcitonin receptor (CTR) agonists induce acute suppression of food intake in rodents by binding to receptors in the area…”
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