Search Results - "Schäffer, Erik"

Kinesin rotates unidirectionally and generates torque while walking on microtubules by Ramaiya, Avin, Roy, Basudev, Bugiel, Michael, Schäffer, Erik

“…Cytoskeletal motors drive many essential cellular processes. For example, kinesin-1 transports cargo in a step-wise manner along microtubules. To resolve…”
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Influence of Enzyme Quantity and Distribution on the Self-Propulsion of Non-Janus Urease-Powered Micromotors by Patiño, Tania, Feiner-Gracia, Natalia, Arqué, Xavier, Miguel-López, Albert, Jannasch, Anita, Stumpp, Tom, Schäffer, Erik, Albertazzi, Lorenzo, Sánchez, Samuel

“…The use of enzyme catalysis to power micro- and nanomachines offers unique features such as biocompatibility, versatility, and fuel bioavailability. Yet, the…”
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Self-Sensing Enzyme-Powered Micromotors Equipped with pH-Responsive DNA Nanoswitches by Patino, Tania, Porchetta, Alessandro, Jannasch, Anita, Lladó, Anna, Stumpp, Tom, Schäffer, Erik, Ricci, Francesco, Sánchez, Samuel

“…Biocatalytic micro- and nanomotors have emerged as a new class of active matter self-propelled through enzymatic reactions. The incorporation of functional…”
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Enzyme-Powered Hollow Mesoporous Janus Nanomotors by Ma, Xing, Jannasch, Anita, Albrecht, Urban-Raphael, Hahn, Kersten, Miguel-López, Albert, Schäffer, Erik, Sánchez, Samuel

“…The development of synthetic nanomotors for technological applications in particular for life science and nanomedicine is a key focus of current basic…”
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Three-Dimensional Optical Tweezers Tracking Resolves Random Sideward Steps of the Kinesin-8 Kip3 by Bugiel, Michael, Schäffer, Erik

“…The budding yeast kinesin-8 Kip3 is a highly processive motor protein that walks to the ends of cytoskeletal microtubules and shortens them in a collective…”
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Protein Friction Limits Diffusive and Directed Movements of Kinesin Motors on Microtubules by Bormuth, Volker, Varga, Vladimir, Howard, Jonathon, Schäffer, Erik

“…Friction limits the operation of macroscopic engines and is critical to the performance of micromechanical devices. We report measurements of friction in a…”
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Germanium nanospheres for ultraresolution picotensiometry of kinesin motors by Sudhakar, Swathi, Abdosamadi, Mohammad Kazem, Jachowski, Tobias Jörg, Bugiel, Michael, Jannasch, Anita, Schäffer, Erik

“…Kinesin motors are essential for the transport of cellular cargo along microtubules. How the motors step, detach, and cooperate with each other is still…”
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Measuring Microtubule Supertwist and Defects by Three-Dimensional-Force-Clamp Tracking of Single Kinesin‑1 Motors by Bugiel, Michael, Mitra, Aniruddha, Girardo, Salvatore, Diez, Stefan, Schäffer, Erik

“…Three-dimensional (3D) nanometer tracking of single biomolecules provides important information about their biological function. However, existing microscopy…”
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Label‐free high‐speed wide‐field imaging of single microtubules using interference reflection microscopy by MAHAMDEH, MOHAMMED, SIMMERT, STEVE, LUCHNIAK, ANNA, SCHÄFFER, ERIK, HOWARD, JONATHON

“…Summary When studying microtubules in vitro, label free imaging of single microtubules is necessary when the quantity of purified tubulin is too low for…”
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Anisotropic and Amphiphilic Mesoporous Core–Shell Silica Microparticles Provide Chemically Selective Environments for Simultaneous Delivery of Curcumin and Quercetin by Dohare, Akanksha, Sudhakar, Swathi, Brodbeck, Björn, Mukherjee, Ashutosh, Brecht, Marc, Kandelbauer, Andreas, Schäffer, Erik, Mayer, Hermann A

“…Porous silica materials are often used for drug delivery. However, systems for simultaneous delivery of multiple drugs are scarce. Here we show that…”
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Single depolymerizing and transport kinesins stabilize microtubule ends by Ciorîță, Alexandra, Bugiel, Michael, Sudhakar, Swathi, Schäffer, Erik, Jannasch, Anita

“…Microtubules are highly dynamic cellular filaments and an accurate control of their length is important for many intracellular processes like cell division…”
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The Kinesin-8 Kip3 Switches Protofilaments in a Sideward Random Walk Asymmetrically Biased by Force by Bugiel, Michael, Böhl, Elisa, Schäffer, Erik

“…Molecular motors translocate along cytoskeletal filaments, as in the case of kinesin motors on microtubules. Although conventional kinesin-1 tracks a single…”
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Supported Solid Lipid Bilayers as a Platform for Single-Molecule Force Measurements by Sudhakar, Swathi, Jachowski, Tobias Jörg, Kittelberger, Michael, Maqbool, Ammara, Hermsdorf, Gero Lutz, Abdosamadi, Mohammad Kazem, Schäffer, Erik

“…Biocompatible surfaces are important for basic and applied research in life science with experiments ranging from the organismal to the single-molecule level…”
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growth speed of microtubules with XMAP215-coated beads coupled to their ends is increased by tensile force by Trushko, Anastasiya, Schäffer, Erik, Howard, Jonathon

“…The generation of pulling and pushing forces is one of the important functions of microtubules, which are dynamic and polarized structures. The ends of dynamic…”
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Inertial effects of a small Brownian particle cause a colored power spectral density of thermal noise by Jannasch, Anita, Mahamdeh, Mohammed, Schäffer, Erik

“…The random thermal force acting on Brownian particles is often approximated in Langevin models by a "white-noise" process. However, fluid entrainment results…”
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The Distribution of Active Force Generators Controls Mitotic Spindle Position by Grill, Stephan W., Howard, Jonathon, Schäffer, Erik, Ernst H. K. Stelzer, Hyman, Anthony A.

“…During unequal cell divisions a mitotic spindle is eccentrically positioned before cell cleavage. To determine the basis of the net force imbalance that causes…”
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Directed rotational motion of birefringent particles by randomly changing the barrier height at the threshold in a washboard potential by Roy, Basudev, Schäffer, Erik

“…This communication presents a simulation study of the directed rotational motion of a birefringent spherical particle trapped in optical tweezers with randomly…”
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Nanophase-Separated Polymer Films as High-Performance Antireflection Coatings by Walheim, Stefan, Schäffer, Erik, Mlynek, Jürgen, Steiner, Ullrich

“…Optical surfaces coated with a thin layer to improve light transmission are ubiquitous in everyday optical applications as well as in industrial and scientific…”
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Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe by Hibbel, Anneke, Bogdanova, Aliona, Mahamdeh, Mohammed, Jannasch, Anita, Storch, Marko, Schäffer, Erik, Liakopoulos, Dimitris, Howard, Jonathon

“…The size and position of mitotic spindles is determined by the lengths of their constituent microtubules. Regulation of microtubule length requires feedback to…”
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A Single-Strand Annealing Protein Clamps DNA to Detect and Secure Homology by Ander, Marcel, Subramaniam, Sivaraman, Fahmy, Karim, Stewart, A Francis, Schäffer, Erik

“…Repair of DNA breaks by single-strand annealing (SSA) is a major mechanism for the maintenance of genomic integrity. SSA is promoted by proteins…”
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