Search Results - "Schäfer, Simon T"

Increased circulating microRNA-122 is a biomarker for discrimination and risk stratification in patients defined by sepsis-3 criteria by Rahmel, Tim, Schäfer, Simon T, Frey, Ulrich H, Adamzik, Michael, Peters, Jürgen

“…Sepsis is now operationally defined as life-threatening organ dysfunction caused by an infection, identified by an acute change in SOFA-Score of at least two…”
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Coagulation under Mild Hypothermia Assessed by Thromboelastometry by Nitschke, Tobias, Groene, Philipp, Acevedo, Alice-Christin, Kammerer, Tobias, Schäfer, Simon T.

“…Introduction: While previous studies have shown a significant impact of extreme hypo- and hyperthermia on coagulation, effects of much more frequently…”
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Modified thromboelastometric tests provide improved sensitivity and specificity to direct oral anticoagulants compared to standard thromboelastometric tests in-vitro by Groene, Philipp, Butte, Jennifer, Thaler, Sarah, Görlinger, Klaus, Schäfer, Simon T

“…Background The detection of direct oral anticoagulants (DOACs) is still challenging but important in emergency patients. We recently demonstrated that modified…”
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Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock by Schäfer, Simon T, Gessner, Sophia, Scherag, André, Rump, Katharina, Frey, Ulrich H, Siffert, Winfried, Westendorf, Astrid M, Steinmann, Jörg, Peters, Jürgen, Adamzik, Michael

“…Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be…”
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Point-of-care detection and differentiation of anticoagulant therapy - development of thromboelastometry-guided decision-making support algorithms by Schäfer, Simon T, Otto, Anne-Christine, Acevedo, Alice-Christin, Görlinger, Klaus, Massberg, Steffen, Kammerer, Tobias, Groene, Philipp

“…DOAC detection is challenging in emergency situations. Here, we demonstrated recently, that modified thromboelastometric tests can reliably detect and…”
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Neutrophil extracellular trap formation and nuclease activity in septic patients by Cox, Linda E, Walstein, Kai, Völlger, Lena, Reuner, Friederike, Bick, Alexandra, Dötsch, Annika, Engler, Andrea, Peters, Jürgen, von Köckritz-Blickwede, Maren, Schäfer, Simon T

“…There is little knowledge, whether in patients with sepsis neutrophil extracellular trap (NET) formation and NET degrading nuclease activity are altered. Thus,…”
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Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils by Völlger, Lena, Akong-Moore, Kathryn, Cox, Linda, Goldmann, Oliver, Wang, Yanming, Schäfer, Simon T, Naim, Hassan Y, Nizet, Victor, von Köckritz-Blickwede, Maren

“…Neutrophil extracellular trap (NET) formation is a significant innate immune defense mechanism against microbial infection that complements other neutrophil…”
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Comparison of Two Different Fibrinogen Concentrates in an in vitro Model of Dilutional Coagulopathy by Groene, Philipp, Wiederkehr, Tobias, Kammerer, Tobias, Möhnle, Patrick, Maerte, Melanie, Bayer, Andreas, Görlinger, Klaus, Rehm, Markus, Schäfer, Simon T.

“…Introduction: Fibrinogen concentrates are widely used to restore clot stability in situations of bleeding. Fibrinogen preparations are produced using different…”
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Acute Exercise in Hypobaric Hypoxia Attenuates Endothelial Shedding in Subjects Unacclimatized to High Altitudes by Kröpfl, Julia M, Kammerer, Tobias, Faihs, Valentina, Gruber, Hans-Jürgen, Stutz, Jan, Rehm, Markus, Stelzer, Ingeborg, Schäfer, Simon T, Spengler, Christina M

“…Travel of unacclimatized subjects to a high altitude has been growing in popularity. Changes in endothelial shedding [circulating endothelial cells (ECs)] and…”
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Hypoxia Inducible Factor-2 Alpha and Prolinhydroxylase 2 Polymorphisms in Patients with Acute Respiratory Distress Syndrome (ARDS) by Dötsch, Annika, Eisele, Lewin, Rabeling, Miriam, Rump, Katharina, Walstein, Kai, Bick, Alexandra, Cox, Linda, Engler, Andrea, Bachmann, Hagen S, Jöckel, Karl-Heinz, Adamzik, Michael, Peters, Jürgen, Schäfer, Simon T

“…Hypoxia-inducible-factor-2α (HIF-2α) and HIF-2 degrading prolyl-hydroxylases (PHD) are key regulators of adaptive hypoxic responses i.e., in acute respiratory…”
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Brain cell type-specific enhancer-promoter interactome maps and disease - risk association by Nott, Alexi, Holtman, Inge R, Coufal, Nicole G, Schlachetzki, Johannes C M, Yu, Miao, Hu, Rong, Han, Claudia Z, Pena, Monique, Xiao, Jiayang, Wu, Yin, Keulen, Zahara, Pasillas, Martina P, O'Connor, Carolyn, Nickl, Christian K, Schafer, Simon T, Shen, Zeyang, Rissman, Robert A, Brewer, James B, Gosselin, David, Gonda, David D, Levy, Michael L, Rosenfeld, Michael G, McVicker, Graham, Gage, Fred H, Ren, Bing, Glass, Christopher K

“…Noncoding genetic variation is a major driver of phenotypic diversity, but functional interpretation is challenging. To better understand common genetic…”
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Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain by Han, Jinju, Kim, Hyung Joon, Schafer, Simon T., Paquola, Apua, Clemenson, Gregory D., Toda, Tomohisa, Oh, Jinseo, Pankonin, Aimee R., Lee, Bo Suk, Johnston, Stephen T., Sarkar, Anindita, Denli, Ahmet M., Gage, Fred H.

“…Altered microRNA profiles have been implicated in human brain disorders. However, the functional contribution of individual microRNAs to neuronal development…”
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Mitochondrial DNA: An Endogenous Trigger for Immune Paralysis by Schäfer, Simon T, Franken, Lars, Adamzik, Michael, Schumak, Beatrix, Scherag, André, Engler, Andrea, Schönborn, Niels, Walden, Jennifer, Koch, Susanne, Baba, Hideo A, Steinmann, Jörg, Westendorf, Astrid M, Fandrey, Joachim, Bieber, Thomas, Kurts, Christian, Frede, Stilla, Peters, Jürgen, Limmer, Andreas

“…BACKGROUND:Critically ill patients are at high risk to suffer from sepsis, even in the absence of an initial infectious source, but the molecular mechanisms…”
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DNA methylation of a NF-κB binding site in the aquaporin 5 promoter impacts on mortality in sepsis by Rump, Katharina, Unterberg, Matthias, Dahlke, Agnes, Nowak, Hartmuth, Koos, Björn, Bergmann, Lars, Siffert, Winfried, Schäfer, Simon T., Peters, Jürgen, Adamzik, Michael, Rahmel, Tim

“…Altered aquaporin 5 ( AQP5 ) expression in immune cells impacts on key mechanisms of inflammation and is associated with sepsis survival. Since epigenetic…”
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Functional testing of tranexamic acid effects in patients undergoing elective orthopaedic surgery by Groene, Philipp, Sappel, Sophia R., Saller, Thomas, Nitschke, Tobias, Sa, Paula A., Paulus, Alexander, Chappell, Daniel, Schäfer, Simon T.

“…Tranexamic acid (TXA) can reduce blood loss and transfusion rates in orthopaedic surgery. In this regard, a new viscoelastometric test (TPA-test, ClotPro),…”
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The Wnt adaptor protein ATP6AP2 regulates multiple stages of adult hippocampal neurogenesis by Schafer, Simon T, Han, Jinju, Pena, Monique, von Bohlen Und Halbach, Oliver, Peters, Jörg, Gage, Fred H

“…In the mammalian hippocampus, canonical Wnt signals provided by the microenvironment regulate the differentiation of adult neural stem cells (NSCs) toward the…”
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A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons by Jaeger, Baptiste N., Linker, Sara B., Parylak, Sarah L., Barron, Jerika J., Gallina, Iryna S., Saavedra, Christian D., Fitzpatrick, Conor, Lim, Christina K., Schafer, Simon T., Lacar, Benjamin, Jessberger, Sebastian, Gage, Fred H.

“…Activity-induced remodeling of neuronal circuits is critical for memory formation. This process relies in part on transcription, but neither the rate of…”
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Effects of Hypobaric Hypoxia on Coagulation in Healthy Subjects Exposed to 3,500 m Altitude by Kammerer, Tobias, Walzl, Anna, Müller, Thomas, Groene, Philipp, Roveri, Giulia, Turner, Rachel, Roche, Johanna, Gatterer, Hannes, Siebenmann, Christoph, Schäfer, Simon T

“…Kammerer, Tobias, Anna Walzl, Thomas Müller, Philipp Groene, Giulia Roveri, Rachel Turner, Johanna Roche, Hannes Gatterer, Christoph Siebenmann, and Simon T…”
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Predictive value of coagulation variables and glycocalyx shedding in hospitalized COVID-19 patients - a prospective observational study by Thaler, Sarah, Stöhr, Dana, Kammerer, Tobias, Nitschke, Tobias, Hoechter, Dominik J., Brandes, Florian, Müller, Martin, Groene, Philipp, Schäfer, Simon T.

“…Covid-19 disease causes an immense burden on the healthcare system. It has not yet been finally clarified which patients will suffer from a severe course and…”
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SDF-1 restores angiogenesis synergistically with VEGF upon LDL exposure despite CXCR4 internalization and degradation by Jin, Fengyan, Hagemann, Nina, Schäfer, Simon T, Brockmeier, Ulf, Zechariah, Anil, Hermann, Dirk M

“…Angiogenesis is compromised under conditions of hypercholesterolaemia. Since disturbed angiogenesis predisposes to ischaemic injuries, efforts have been made…”
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