Search Results - "Schäfer, Silke A"

Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function by Staiger, Harald, Machicao, Fausto, Stefan, Norbert, Tschritter, Otto, Thamer, Claus, Kantartzis, Konstantinos, Schäfer, Silke A, Kirchhoff, Kerstin, Fritsche, Andreas, Häring, Hans-Ulrich

“…Type 2 diabetes arises when insulin resistance-induced compensatory insulin secretion exhausts. Insulin resistance and/or beta-cell dysfunction result from the…”
Get full text

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function by Staiger, Harald, Machicao, Fausto, Schäfer, Silke A, Kirchhoff, Kerstin, Kantartzis, Konstantinos, Guthoff, Martina, Silbernagel, Günther, Stefan, Norbert, Häring, Hans-Ulrich, Fritsche, Andreas

“…Very recently, a novel type 2 diabetes risk gene, i.e., MTNR1B, was identified and reported to affect fasting glycemia. Using our thoroughly phenotyped cohort…”
Get full text

Glycemia Determines the Effect of Type 2 Diabetes Risk Genes on Insulin Secretion by HENI, Martin, KETTERER, Caroline, THAMER, Claus, HERZBERG-SCHÄFER, Silke A, GUTHOFF, Martina, STEFAN, Norbert, MACHICAO, Fausto, STAIGER, Harald, FRITSCHE, Andreas, HÄRING, Hans-Ulrich

“…Several single nucleotide polymorphisms (SNPs) in diabetes risk genes reduce glucose- and/or incretin-induced insulin secretion. Here, we investigated…”
Get full text

Variations in PPARD Determine the Change in Body Composition during Lifestyle Intervention: A Whole-Body Magnetic Resonance Study by Thamer, Claus, Machann, Jürgen, Stefan, Norbert, Schäfer, Silke A., Machicao, Fausto, Staiger, Harald, Laakso, Markku, Böttcher, Michael, Claussen, Claus, Schick, Fritz, Fritsche, Andreas, Haring, Hans-Ulrich

“…Context: We recently demonstrated that single-nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptor-δ gene (PPARD), i.e. rs1053049,…”
Get full text

Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function by Herzberg-Schäfer, Silke A, Staiger, Harald, Heni, Martin, Ketterer, Caroline, Guthoff, Martina, Kantartzis, Konstantinos, Machicao, Fausto, Stefan, Norbert, Häring, Hans-Ulrich, Fritsche, Andreas

“…To date, fasting state- and different oral glucose tolerance test (OGTT)-derived measures are used to estimate insulin release with reasonable effort in large…”
Get full text

Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes by Staiger, Harald, Machicao, Fausto, Kantartzis, Konstantinos, Schäfer, Silke A, Kirchhoff, Kerstin, Guthoff, Martina, Silbernagel, Günther, Stefan, Norbert, Fritsche, Andreas, Häring, Hans-Ulrich

“…Genome-wide association (GWA) studies identified a series of novel type 2 diabetes risk loci. Most of them were subsequently demonstrated to affect insulin…”
Get full text

Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion by Heni, Martin, Haupt, Axel, Schäfer, Silke A, Ketterer, Caroline, Thamer, Claus, Machicao, Fausto, Stefan, Norbert, Staiger, Harald, Häring, Hans-Ulrich, Fritsche, Andreas

“…Prohormone convertase 1 is involved in maturation of peptides. Rare mutations in gene PCSK1, encoding this enzyme, cause childhood obesity and abnormal glucose…”
Get full text

Cerebrocortical beta activity in overweight humans responds to insulin detemir by Tschritter, Otto, Hennige, Anita M, Preissl, Hubert, Porubska, Katarina, Schäfer, Silke A, Lutzenberger, Werner, Machicao, Fausto, Birbaumer, Niels, Fritsche, Andreas, Häring, Hans-Ulrich

“…Insulin stimulates cerebrocortical beta and theta activity in lean humans. This effect is reduced in obese individuals indicating cerebrocortical insulin…”
Get full text

Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin by Wagner, Robert, Dudziak, Katarzyna, Herzberg-Schäfer, Silke A, Machicao, Fausto, Stefan, Norbert, Staiger, Harald, Häring, Hans-Ulrich, Fritsche, Andreas

“…Recent meta-analyses of genome-wide association studies revealed new genetic loci associated with fasting glycemia. For several of these loci, the mechanism of…”
Get full text

Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion by Heni, Martin, Ketterer, Caroline, Wagner, Robert, Linder, Katarzyna, Böhm, Anja, Herzberg-Schäfer, Silke A, Machicao, Fausto, Knoch, Klaus-Peter, Fritsche, Andreas, Staiger, Harald, Häring, Hans-Ulrich, Solimena, Michele

“…Polypyrimidine tract-binding protein 1 (PTBP1) promotes stability and translation of mRNAs coding for insulin secretion granule proteins and thereby plays a…”
Get full text

The Impact of Genetic Variation in the G6PC2 Gene on Insulin Secretion Depends on Glycemia by Heni, Martin, Ketterer, Caroline, Hart, Leen M. 't, Ranta, Felicia, van Haeften, Timon W, Eekhoff, Elisabeth M, Dekker, Jacqueline M, Boomsma, Dorret I, Nijpels, Giel, Kramer, Mark H, Diamant, Michaela, Simonis-Bik, Annemarie M, Heine, Robert J, de Geus, Eco J, Schäfer, Silke A, Machicao, Fausto, Ullrich, Susanne, Thamer, Claus, Stefan, Norbert, Staiger, Harald, Häring, Hans-Ulrich, Fritsche, Andreas

“…Context: Single-nucleotide polymorphisms (SNPs) within the G6PC2 locus are associated with fasting glucose and insulin secretion. These SNPs are not associated…”
Get full text

Common polymorphisms within the NR4A3 locus, encoding the orphan nuclear receptor Nor-1, are associated with enhanced beta-cell function in non-diabetic subjects by Weyrich, Peter, Staiger, Harald, Stancáková, Alena, Schäfer, Silke A, Kirchhoff, Kerstin, Ullrich, Susanne, Ranta, Felicia, Gallwitz, Baptist, Stefan, Norbert, Machicao, Fausto, Kuusisto, Johanna, Laakso, Markku, Fritsche, Andreas, Häring, Hans-Ulrich

“…Neuron-derived orphan receptor (Nor) 1, nuclear receptor (Nur) 77, and nuclear receptor-related protein (Nurr) 1 constitute the NR4A family of orphan nuclear…”
Get full text

The CTRB1/2 Locus Affects Diabetes Susceptibility and Treatment via the Incretin Pathway by 'T HART, Leen M, FRITSCHE, Andreas, PALMER, Colin N. A, VAN HAEFTEN, Timon W, HERZBERG-SCHÄFER, Silke A, SIMONIS-BIK, Annemarie M. C, HOUWING-DUISTERMAAT, Jeanine J, HELMER, Quinta, DEELEN, Joris, GUIGAS, Bruno, HANSEN, Torben, MACHICAO, Fausto, NIJPELS, Giel, WILLEMSEN, Gonneke, HEINE, Robert J, KRAMER, Mark H. H, HOLST, Jens J, DE KONING, Eelco J. P, HÄRING, Hans-Ulrich, PEDERSEN, Oluf, GROOP, Leif, DE GEUS, Eco J. C, SLAGBOOM, P. Eline, VAN LEEUWEN, Nienke, BOOMSMA, Dorret I, EEKHOFF, Elisabeth M. W, PEARSON, Ewan R, DIAMANT, Michaela, DONNELLY, Louise A, DEKKER, Jacqueline M, ALSSEMA, Marjan, FADISTA, Joao, CARLOTTI, Françoise, GJESING, Anette P

“…The incretin hormone glucagon-like peptide 1 (GLP-1) promotes glucose homeostasis and enhances β-cell function. GLP-1 receptor agonists (GLP-1 RAs) and…”
Get full text

Association of Type 2 Diabetes Candidate Polymorphisms in KCNQ1 With Incretin and Insulin Secretion by MÜSSIG, Karsten, STAIGER, Harald, GALLWITZ, Baptist, HÄRING, Hans-Ulrich, FRITSCHE, Andreas, MACHICAO, Fausto, KIRCHHOFF, Kerstin, GUTHOFF, Martina, SCHÄFER, Silke A, KANTARTZIS, Konstantinos, SILBERNAGEL, Günther, STEFAN, Norbert, HOLST, Jens J

“…Association of Type 2 Diabetes Candidate Polymorphisms in KCNQ1 With Incretin and Insulin Secretion Karsten Müssig 1 , Harald Staiger 1 , Fausto Machicao 1 ,…”
Get full text

New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms by Schäfer, Silke A, Machicao, Fausto, Fritsche, Andreas, Häring, Hans-Ulrich, Kantartzis, Konstantinos

“…Abstract Type 2 diabetes results from the inability of beta cells to increase insulin secretion sufficiently to compensate for insulin resistance. Insulin…”
Get full text

Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic Clamps by 't Hart, Leen M, Simonis-Bik, Annemarie M, Nijpels, Giel, van Haeften, Timon W, Schäfer, Silke A, Houwing-Duistermaat, Jeanine J, Boomsma, Dorret I, Groenewoud, Marlous J, Reiling, Erwin, van Hove, Els C, Diamant, Michaela, Kramer, Mark H H, Heine, Robert J, Maassen, J Antonie, Kirchhoff, Kerstin, Machicao, Fausto, Häring, Hans-Ulrich, Slagboom, P Eline, Willemsen, Gonneke, Eekhoff, Elisabeth M, de Geus, Eco J, Dekker, Jacqueline M, Fritsche, Andreas

“…Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First-Phase Glucose-Stimulated Insulin Secretion During Hyperglycemic…”
Get full text

The Inhibitory Effect of Recent Type 2 Diabetes Risk Loci on Insulin Secretion Is Modulated by Insulin Sensitivity by Haupt, Axel, Guthoff, Martina, Schäfer, Silke A., Kirchhoff, Kerstin, Machicao, Fausto, Gallwitz, Baptist, Staiger, Harald, Stefan, Norbert, Fritsche, Andreas, Häring, Hans-Ulrich

“…Context/Objective: Recently novel type 2 diabetes risk loci were identified and reported to associate with β-cell dysfunction. We assessed whether the risk…”
Get full text

Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus by Müssig, Karsten, Staiger, Harald, Machicao, Fausto, Machann, Jürgen, Schick, Fritz, Schäfer, Silke A, Claussen, Claus D, Holst, Jens J, Gallwitz, Baptist, Stefan, Norbert, Fritsche, Andreas, Häring, Hans-Ulrich

“…Abstract Bile acids are signaling molecules with important endocrine functions. Some of these, including the induction of energy expenditure in brown adipose…”
Get full text

Biochemical and morphological effects of K-111, a peroxisome proliferator-activated receptor (PPAR)α activator, in non-human primates by Schäfer, Silke A, Hansen, Barbara C, Völkl, Alfred, Fahimi, H.Dariush, Pill, Johannes

“…K-111 has been characterized as a potent peroxisome proliferator-activated receptor (PPAR)α activator. Antidiabetic potency and amelioration of disturbed lipid…”
Get full text

Association of obesity risk SNPs in PCSK1with insulin sensitivity and proinsulin conversion by Heni, Martin, Haupt, Axel, Schäfer, Silke A, Ketterer, Caroline, Thamer, Claus, Machicao, Fausto, Stefan, Norbert, Staiger, Harald, Häring, Hans-Ulrich, Fritsche, Andreas

“…Abstract Background Prohormone convertase 1 is involved in maturation of peptides. Rare mutations in gene PCSK1 , encoding this enzyme, cause childhood obesity…”
Get full text