Development of the cardiorespiratory system in dogs from days 16 to 46 of pregnancy

Contents Dogs have been studied for several reasons, such as the genetic improvement, their use as experimental models, in zoonotic research, cell therapy and as a model for human diseases. However, many features relating to the embryonic development of dogs remain unknown because of the absence of...

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Bibliographic Details
Published in:	Reproduction in domestic animals Vol. 51; no. 5; pp. 804 - 812
Main Authors:	Martins, AA, Favaron, PO, de Jesus Oliveira, L, Schäfer, BT, Oliveira, FD, Miglino, MA
Format:	Journal Article
Language:	English
Published:	Germany Blackwell Publishing Ltd 01-10-2016
Subjects:	Animal reproduction Animals Blood vessels Bronchi Bronchus Cell culture Developmental stages Dogs Dogs - embryology Dogs - physiology Embryogenesis Embryonic growth stage Embryos Female Fetal Development - physiology Fetuses Gestation Gestational Age Heart Heart - embryology Lung - embryology Lungs Neural tube Organs Pregnancy Respiratory system Septum Somites Trachea Zoonoses
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Summary:	Contents Dogs have been studied for several reasons, such as the genetic improvement, their use as experimental models, in zoonotic research, cell therapy and as a model for human diseases. However, many features relating to the embryonic development of dogs remain unknown because of the absence of embryological studies. Considering the importance of the cardiorespiratory system in the development of embryos, the aim of this study was to investigate the development of the main cardiorespiratory organs of dog embryos and foetuses with estimated gestational ages from 16 to 46 days using macro‐ and microscopic descriptions. On day 16 of development, the neural tube and crest were formed, the anterior and posterior neuropore closure had begun and the somites had developed. Between days 22 and 27 of gestation, the lung buds and the initial formation of the primary bronchi and heart chambers were observed. The heart chambers exhibited the endo‐, myo‐ and epicardial layers but did not have obvious differences in thickness among each other. Between days 41 and 46 of gestation, the nasal conchae and septa and trachea were formed, which exhibited characteristic epithelia. The lung formation and lobation were complete. The heart and major vessels exhibited mature histological architecture when their anatomical development was complete. The results of this study contribute to a more accurate definition of the embryonic and foetal developmental stages in dogs.
Bibliography:	ark:/67375/WNG-CVH7F7PL-S istex:A3C2BF9160997F596A9139CCE7530373142AE1E9 ArticleID:RDA12759 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0936-6768 1439-0531
DOI:	10.1111/rda.12759